Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function

doi:10.1002/advs.202307812

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题名	Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function
作者	Han, Yue1; Tong, Xian1; Zhou, Runqi1; Wang, Yilin1; Chen, Yuge1,2; Chen, Liang1; Hong, Xinhua1; Wu, Linmei1; Lin, Zhiqiang1; Zhang, Yichi1; Zhang, Xuejia1; Hu, Chaoming1; Li, Bin1; Ping, Yifan 1; Cao, Zelin 1; Ye, Zhou 3; Song, Zhongchen 4; Li, Yuncang 5; Wen, Cuie 5; Zhou, Yongsheng 6; Lin, Jixing1; Huang, Shengbin1
发表日期	2024-01-19
发表期刊	ADVANCED SCIENCE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access ; Article in Press
关键词	biodegradable zinc alloy bone fracture osteointegration rare earth dysprosium (Dy) SIRT4 Binary alloys Biodegradability Computerized tomography Degradation Fracture High strength alloys Mechanical stability Mitochondria Rare earths Biodegradable zinc alloy Bone fracture Bone healing Fracture healing Mitochondrial function Osteointegration Property Rare earth dysprosium Rare-earths
其他关键词	IN-VITRO ; MECHANICAL-PROPERTIES ; ANGIOGENESIS ; SIRTUINS ; BEHAVIOR ; BIOCOMPATIBILITY ; OSTEOGENESIS ; APOPTOSIS ; EXOSOMES ; MODEL
摘要	Zinc (Zn)-dysprosium (Dy) binary alloys are promising biodegradable bone fracture fixation implants owing to their attractive biodegradability and mechanical properties. However, their clinical application is a challenge for bone fracture healing, due to the lack of Zn-Dy alloys with tailored proper bio-mechanical and osteointegration properties for bone regeneration. A Zn-5Dy alloy with high strength and ductility and a degradation rate aligned with the bone remodeling cycle is developed. Here, mechanical stability is further confirmed, proving that Zn-5Dy alloy can resist aging in the degradation process, thus meeting the mechanical requirements of fracture fixation. In vitro cellular experiments reveal that the Zn-5Dy alloy enhances osteogenesis and angiogenesis by elevating SIRT4-mediated mitochondrial function. In vivo Micro-CT, SEM-EDS, and immunohistochemistry analyses further indicate good biosafety, suitable biodegradation rate, and great osteointegration of Zn-5Dy alloy during bone healing, which also depends on the upregulation of SIRT4-mediated mitochondrial events. Overall, the study is the first to report a Zn-5Dy alloy that exerts remarkable osteointegration properties and has a strong potential to promote bone healing. Furthermore, the results highlight the importance of mitochondrial modulation and shall guide the future development of mitochondria-targeting materials in enhancing bone fracture healing. Zinc (Zn)-dysprosium (Dy) binary alloys are promising biodegradable bone fracture fixation implants. The Zn-5Dy alloy exerts remarkable osteogenesis and angiogenesis properties dependent on the upregulation of SIRT4-mediated mitochondrial events. This study highlights the importance of mitochondrial modulation and guides the future development of mitochondria-targeting biodegradable metal materials in enhancing bone fracture healing.image
资助项目	Zhejiang Xinmiao Talents Program [82270991]; Natural Science Foundation of China [LR21H140002]; Zhejiang Provincial Natural Science Foundation of China/Outstanding Youth Science Foundation [WKJ-ZJ-2311]; Medical Health Science and Technology Major Project of Zhejiang Provincial Health Commission [ZY2021015]; Wenzhou Science and Technology Bureau Public Welfare Social Development (Medical and Health) Science and Technology Project [2022SKLS-KFKT011]; Opening Research Fund from Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine [GXKLRROM2106]; Guangxi Key Laboratory of the Rehabilitation and Reconstruction for Oral and Maxillofacial Research [2021R413083]; Zhejiang Provincial College Students' Science and Technology Innovation Project and Fresh Talent Program
出版者	WILEY
ISSN	2198-3844
EISSN	2198-3844
DOI	10.1002/advs.202307812
页数	21
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001145178900001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20240415413136
EI主题词	Zinc alloys
EI分类号	461.2 Biological Materials and Tissue Engineering ; 531.1 Metallurgy ; 546.3 Zinc and Alloys ; 723.5 Computer Applications ; 801.2 Biochemistry ; 802.2 Chemical Reactions ; 804.2 Inorganic Compounds ; 951 Materials Science
URL	查看原文
PubMed ID	38243646
SCOPUSEID	2-s2.0-85182690296
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/206866
专题	口腔医学院、附属口腔医院口腔医学院、附属口腔医院_口腔医学研究所
通讯作者	Wen, Cuie; Zhou, Yongsheng; Lin, Jixing; Huang, Shengbin
作者单位	1.Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325027, Peoples R China; 2.Univ Alberta, Fac Med & Dent, Dept Dent, Edmonton, AB T6G2R3, Canada; 3.Univ Hong Kong, Fac Dent, Appl Oral Sci & Community Dent Care, Hong Kong 999077, Peoples R China; 4.Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Periodontol, Shanghai 200125, Peoples R China; 5.RMIT Univ, Sch Engn, Melbourne, Vic 3001, Australia; 6.Peking Univ, Nat Engn Res Ctr Oral Biomat & Digital Med Devices, Natl Clin Res Ctr Oral Dis, Sch & Hosp Stomatol,Nat Ctr Stomatol,Dept Prosthod, Beijing 100081, Peoples R China
第一作者单位	口腔医学院、附属口腔医院; 口腔医学研究所
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Han, Yue,Tong, Xian,Zhou, Runqi,et al. Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function[J]. ADVANCED SCIENCE,2024.
APA	Han, Yue., Tong, Xian., Zhou, Runqi., Wang, Yilin., Chen, Yuge., ... & Huang, Shengbin. (2024). Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function. ADVANCED SCIENCE.
MLA	Han, Yue,et al."Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function".ADVANCED SCIENCE (2024).

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