| 题名 | Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function |
| 作者 | Han, Yue1
 ; Tong, Xian1; Zhou, Runqi1; Wang, Yilin1; Chen, Yuge1,2; Chen, Liang1; Hong, Xinhua1; Wu, Linmei1; Lin, Zhiqiang1; Zhang, Yichi1; Zhang, Xuejia1; Hu, Chaoming1; Li, Bin1; Ping, Yifan1; Cao, Zelin1; Ye, Zhou3; Song, Zhongchen4; Li, Yuncang5; Wen, Cuie5; Zhou, Yongsheng6; Lin, Jixing1; Huang, Shengbin1 |
| 发表日期 | 2024-01-19 |
| 发表期刊 | ADVANCED SCIENCE 影响因子和分区 |
| 语种 | 英语 |
| 原始文献类型 | Article ; Early Access ; Article in Press |
| 关键词 | biodegradable zinc alloy bone fracture osteointegration rare earth dysprosium (Dy) SIRT4 Binary alloys Biodegradability Computerized tomography Degradation Fracture High strength alloys Mechanical stability Mitochondria Rare earths Biodegradable zinc alloy Bone fracture Bone healing Fracture healing Mitochondrial function Osteointegration Property Rare earth dysprosium Rare-earths |
| 其他关键词 | IN-VITRO ; MECHANICAL-PROPERTIES ; ANGIOGENESIS ; SIRTUINS ; BEHAVIOR ; BIOCOMPATIBILITY ; OSTEOGENESIS ; APOPTOSIS ; EXOSOMES ; MODEL |
| 摘要 | Zinc (Zn)-dysprosium (Dy) binary alloys are promising biodegradable bone fracture fixation implants owing to their attractive biodegradability and mechanical properties. However, their clinical application is a challenge for bone fracture healing, due to the lack of Zn-Dy alloys with tailored proper bio-mechanical and osteointegration properties for bone regeneration. A Zn-5Dy alloy with high strength and ductility and a degradation rate aligned with the bone remodeling cycle is developed. Here, mechanical stability is further confirmed, proving that Zn-5Dy alloy can resist aging in the degradation process, thus meeting the mechanical requirements of fracture fixation. In vitro cellular experiments reveal that the Zn-5Dy alloy enhances osteogenesis and angiogenesis by elevating SIRT4-mediated mitochondrial function. In vivo Micro-CT, SEM-EDS, and immunohistochemistry analyses further indicate good biosafety, suitable biodegradation rate, and great osteointegration of Zn-5Dy alloy during bone healing, which also depends on the upregulation of SIRT4-mediated mitochondrial events. Overall, the study is the first to report a Zn-5Dy alloy that exerts remarkable osteointegration properties and has a strong potential to promote bone healing. Furthermore, the results highlight the importance of mitochondrial modulation and shall guide the future development of mitochondria-targeting materials in enhancing bone fracture healing. Zinc (Zn)-dysprosium (Dy) binary alloys are promising biodegradable bone fracture fixation implants. The Zn-5Dy alloy exerts remarkable osteogenesis and angiogenesis properties dependent on the upregulation of SIRT4-mediated mitochondrial events. This study highlights the importance of mitochondrial modulation and guides the future development of mitochondria-targeting biodegradable metal materials in enhancing bone fracture healing.image |
| 资助项目 | Zhejiang Xinmiao Talents Program [82270991]; Natural Science Foundation of China [LR21H140002]; Zhejiang Provincial Natural Science Foundation of China/Outstanding Youth Science Foundation [WKJ-ZJ-2311]; Medical Health Science and Technology Major Project of Zhejiang Provincial Health Commission [ZY2021015]; Wenzhou Science and Technology Bureau Public Welfare Social Development (Medical and Health) Science and Technology Project [2022SKLS-KFKT011]; Opening Research Fund from Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine [GXKLRROM2106]; Guangxi Key Laboratory of the Rehabilitation and Reconstruction for Oral and Maxillofacial Research [2021R413083]; Zhejiang Provincial College Students' Science and Technology Innovation Project and Fresh Talent Program |
| 出版者 | WILEY |
| ISSN | 2198-3844 |
| EISSN | 2198-3844 |
| DOI | 10.1002/advs.202307812 |
| 页数 | 21 |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS记录号 | WOS:001145178900001 |
| 收录类别 | SCIE ; PUBMED ; EI ; SCOPUS |
| EI入藏号 | 20240415413136 |
| EI主题词 | Zinc alloys |
| EI分类号 | 461.2 Biological Materials and Tissue Engineering ; 531.1 Metallurgy ; 546.3 Zinc and Alloys ; 723.5 Computer Applications ; 801.2 Biochemistry ; 802.2 Chemical Reactions ; 804.2 Inorganic Compounds ; 951 Materials Science |
| URL | 查看原文 |
| PubMed ID | 38243646 |
| SCOPUSEID | 2-s2.0-85182690296 |
| TOP期刊 | TOP期刊 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/206866 |
| 专题 | 口腔医学院、附属口腔医院 口腔医学院、附属口腔医院_口腔医学研究所 |
| 通讯作者 | Wen, Cuie; Zhou, Yongsheng; Lin, Jixing; Huang, Shengbin |
| 作者单位 | 1.Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325027, Peoples R China; 2.Univ Alberta, Fac Med & Dent, Dept Dent, Edmonton, AB T6G2R3, Canada; 3.Univ Hong Kong, Fac Dent, Appl Oral Sci & Community Dent Care, Hong Kong 999077, Peoples R China; 4.Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Periodontol, Shanghai 200125, Peoples R China; 5.RMIT Univ, Sch Engn, Melbourne, Vic 3001, Australia; 6.Peking Univ, Nat Engn Res Ctr Oral Biomat & Digital Med Devices, Natl Clin Res Ctr Oral Dis, Sch & Hosp Stomatol,Nat Ctr Stomatol,Dept Prosthod, Beijing 100081, Peoples R China |
| 第一作者单位 | 口腔医学院、附属口腔医院; 口腔医学研究所 |
| 第一作者的第一单位 | 口腔医学院、附属口腔医院 |
| 推荐引用方式 GB/T 7714 | Han, Yue,Tong, Xian,Zhou, Runqi,et al. Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function[J]. ADVANCED SCIENCE,2024. |
| APA | Han, Yue., Tong, Xian., Zhou, Runqi., Wang, Yilin., Chen, Yuge., ... & Huang, Shengbin. (2024). Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function. ADVANCED SCIENCE. |
| MLA | Han, Yue,et al."Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function".ADVANCED SCIENCE (2024). |
条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Advanced Science - 2（17552KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
| 个性服务 |
| 查看访问统计 |
| 谷歌学术 |
| 谷歌学术中相似的文章 |
| [Han, Yue]的文章 |
| [Tong, Xian]的文章 |
| [Zhou, Runqi]的文章 |
| 百度学术 |
| 百度学术中相似的文章 |
| [Han, Yue]的文章 |
| [Tong, Xian]的文章 |
| [Zhou, Runqi]的文章 |
| 必应学术 |
| 必应学术中相似的文章 |
| [Han, Yue]的文章 |
| [Tong, Xian]的文章 |
| [Zhou, Runqi]的文章 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
学校主页 
图书馆
修改评论