Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant blaOXA-232-Carrying Klebsiella pneumoniae Sequence Type 15 Lineage

doi:10.3201/eid2911.230463

科研成果详情

题名	Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant blaOXA-232-Carrying Klebsiella pneumoniae Sequence Type 15 Lineage
作者	Wu, Yuye 1; Jiang, Tian1,2; He, Xianhong 1,3,8; Shao, Jiayu 1,3; Wu, Chenghao 1; Mao, Weifang 1,4; Jia, Huiqiong 5,6; He, Fang 7; Kong, Yingying 1,8; Wu, Jianyong 9; Sun, Qingyang 10; Sun, Long 11; Draz, Mohamed S.12,13; Xie, Xinyou 1; Zhang, Jun 1,8; Ruan, Zhi 1,8
发表日期	2023-11
发表期刊	EMERGING INFECTIOUS DISEASES 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	KLEBSIELLA-PNEUMONIAE ; BETA-LACTAMASE ; EMERGENCE ; IMIPENEM ; OXA-232 ; HISTORY
摘要	Prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) has compromised antimicrobial efficacy against severe infections worldwide. To monitor global spread, we conducted a comprehensive genomic epidemiologic study comparing sequences from 21 blaOXA-232- carrying CRKP isolates from China with K. pneumoniae sequence type (ST) 15 strains from 68 countries available in GenBank. Phylogenetic and phylogeographic analyses revealed all blaOXA-232-carrying CRKP isolates belonged to ST15 lineage and exhibited multidrug resistance. Analysis grouped 330 global blaOXA-232-carrying ST15 CRKP strains into 5 clades, indicating clonal transmission with small genetic distances among multiple strains. The lineage originated in the United States, then spread to Europe, Asia, Oceania, and Africa. Most recent common ancestor was traced back to 2000; mutations averaged approximate to 1.7 per year per genome. Our research helps identify key forces driving global spread of blaOXA-232-car-rying CRKP ST15 lineage and emphasizes the importance of ongoing surveillance of epidemic CRKP.
资助项目	National Natural Science Foundation of China [82102436, 81871696, 82202565]; Zhejiang Provincial Natural Science Foundation of China [LR23H200001, LY21H190001, LQ22H200001]; Zhejiang Provincial Medical and Health Science and Technology Plan [2020RC066, 2021RC007, 2022RC299, 2023KY227, 2023KY228]
出版者	CENTERS DISEASE CONTROL & PREVENTION
ISSN	1080-6040
EISSN	1080-6059
卷号	29 期号:11 页码:2246-2256
DOI	10.3201/eid2911.230463
页数	11
WOS类目	Immunology ; Infectious Diseases
WOS研究方向	Immunology ; Infectious Diseases
WOS记录号	WOS:001127982900041
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	37877525
SCOPUSEID	2-s2.0-85175269965
通讯作者地址	[Xie, Xinyou]Department of Clinical Laboratory,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,3 East Qingchun Rd,Hangzhou,310016,China ; [Zhang, Jun]Department of Clinical Laboratory,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,3 East Qingchun Rd,Hangzhou,310016,China ; [Ruan, Zhi]Department of Clinical Laboratory,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,3 East Qingchun Rd,Hangzhou,310016,China
Scopus学科分类	Epidemiology;Microbiology (medical);Infectious Diseases
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/206789
专题	其他_附属温岭医院（温岭市第一人民医院）
通讯作者	Xie, Xinyou; Zhang, Jun; Ruan, Zhi
作者单位	1.Zhejiang University School of Medicine,Sir Run Run Shaw Hospital,Hangzhou,China; 2.Wenzhou Medical University Affiliated Wenling Hospital,Taizhou,China; 3.Third People’s Hospital of Xiaoshan District,Hangzhou,China; 4.Shaoxing University Affiliated Hospital,Shaoxing,China; 5.Zhejiang University School of Medicine First Affiliated Hospital,Hangzhou,China; 6.Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province,Hangzhou,China; 7.Zhejiang Provincial People’s Hospital,Hangzhou,China; 8.Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province,Hangzhou,China; 9.Zhejiang University School of Medicine Fourth Affiliated Hospital,Hangzhou,China; 10.No. 903 Hospital of PLA Joint Logistic Support Force,Hangzhou,China; 11.Hangzhou Women’s Hospital,Hangzhou,China; 12.Case Western Reserve University School of Medicine,Cleveland,United States; 13.Cleveland Clinic,Cleveland,United States
推荐引用方式 GB/T 7714	Wu, Yuye,Jiang, Tian,He, Xianhong,et al. Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant blaOXA-232-Carrying Klebsiella pneumoniae Sequence Type 15 Lineage[J]. EMERGING INFECTIOUS DISEASES,2023,29(11):2246-2256.
APA	Wu, Yuye., Jiang, Tian., He, Xianhong., Shao, Jiayu., Wu, Chenghao., ... & Ruan, Zhi. (2023). Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant blaOXA-232-Carrying Klebsiella pneumoniae Sequence Type 15 Lineage. EMERGING INFECTIOUS DISEASES, 29(11), 2246-2256.
MLA	Wu, Yuye,et al."Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant blaOXA-232-Carrying Klebsiella pneumoniae Sequence Type 15 Lineage".EMERGING INFECTIOUS DISEASES 29.11(2023):2246-2256.