科研成果详情

题名Clinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction
作者
发表日期2024-05
发表期刊Clinical research in cardiology : official journal of the German Cardiac Society   影响因子和分区
语种英语
原始文献类型Journal Article
关键词End-stage heart failure Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction Hypertrophic cardiomyopathy Prognosis
其他关键词CARDIAC RESYNCHRONIZATION THERAPY ; TASK-FORCE ; MANAGEMENT ; DIAGNOSIS
摘要Whether heart failure with preserved ejection fraction (HFpEF) is associated with an increased risk of developing systolic dysfunction and a poor prognosis in hypertrophic cardiomyopathy (HCM) patients is unknown., We aimed to assess risk factors for the development of end-stage (ES) heart failure (HF) (ejection fraction < 50%) and compare the prognosis of different HF phenotypes., This retrospective study was conducted on patients with HCM in China between January 2009 and February 2023. Patients were stratified into three different groups: HCM-non-HF, HCM-HFpEF and HCM-heart failure with reduced ejection fraction (HCM-HFrEF). The primary outcome was a composite of major adverse cardiac events (MACEs), including all-cause deaths, HF hospitalization, sudden cardiac death and ventricular tachycardia., Of 3,620 HCM patients enrolled, 1,553 (42.9%) had non-HF, 1,666 (46.0%) had HFpEF, and 579 patients (11.1%) had HFrEF at baseline. During the median follow-up period of 4.0 years (IQR 1.4-9.4 years), patients with HCM-HFpEF exhibited a higher incidence of ES-HF than those with HCM-non-HF (12.4% vs. 2.7%, P < 0.001). HFpEF was an independent risk factor for ES-HF development (HR 3.84, 2.54-5.80, P < 0.001). MACEs occurred in 26.9% with a higher incidence in HCM-HFpEF than HCM-non-HF (36.6% vs 12.2%, P < 0.001). HFpEF was an independent predictor of MACEs (HR 2.13, 1.75-2.59, P < 0.001)., HFpEF is common in HCM. Compared to non-HF, it increases the risk of LVEF decline and poor prognosis. It may aid in risk stratification and need close echocardiography follow-up.
资助项目Wenzhou Science Technology Bureau Foundation[Y20220081];Wenzhou Science Technology Bureau Foundation[2022Y0726]
出版者SPRINGER HEIDELBERG
ISSN1861-0684
EISSN1861-0692
卷号113期号:5页码:761-769
DOI10.1007/s00392-023-02371-5
页数9
WOS类目Cardiac & Cardiovascular Systems
WOS研究方向Cardiovascular System & Cardiology
WOS记录号WOS:001140142700001
收录类别PUBMED ; SCIE ; SCOPUS
在线发表日期2024-01
URL查看原文
PubMed ID38197895
SCOPUSEID2-s2.0-85181947396
通讯作者地址[Zhou, Xiao-Dong]Department of Cardiovascular Medicine,The Heart Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类Cardiology and Cardiovascular Medicine
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/205883
专题附属第一医院
卓越中心_老年研究院
通讯作者Zhou, Xiao-Dong
作者单位
1.Medical Care Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Nanbaixiang,325100,China;
2.Institute of Aging,Key Laboratory of Alzheimer’s Disease of Zhejiang Province,Wenzhou Medical University,Wenzhou,325000,China;
3.Department of Information,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China;
4.Department of Cardiovascular Medicine,The Heart Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China;
5.Division of Cardiovascular Medicine,Department of Medicine,University of Minnesota Medical School,Minneapolis,United States
第一作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院;  温州医科大学
通讯作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Chen, Qin-Fen,Hu, Jiandong,Hu, Jie,et al. Clinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction[J]. Clinical research in cardiology : official journal of the German Cardiac Society,2024,113(5):761-769.
APA Chen, Qin-Fen., Hu, Jiandong., Hu, Jie., Nijjar, Prabhjot S.., Xu, Jiahui., ... & Zhou, Xiao-Dong. (2024). Clinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction. Clinical research in cardiology : official journal of the German Cardiac Society, 113(5), 761-769.
MLA Chen, Qin-Fen,et al."Clinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction".Clinical research in cardiology : official journal of the German Cardiac Society 113.5(2024):761-769.

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