Clinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction

doi:10.1007/s00392-023-02371-5

科研成果详情

题名	Clinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction
作者	Chen, Qin-Fen1,2; Hu, Jiandong3; Hu, Jie 4; Nijjar, Prabhjot S.5; Xu, Jiahui4; Shi, Shanzhen 4; Liang, Dongjie4; Liao, Hetong2; Gao, Jiaqi2; Lin, Wei-Hong1; You, Shenban 4; Zhou, Xiao-Dong 4
发表日期	2024-05
发表期刊	Clinical research in cardiology : official journal of the German Cardiac Society 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	End-stage heart failure Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction Hypertrophic cardiomyopathy Prognosis
其他关键词	CARDIAC RESYNCHRONIZATION THERAPY ; TASK-FORCE ; MANAGEMENT ; DIAGNOSIS
摘要	Whether heart failure with preserved ejection fraction (HFpEF) is associated with an increased risk of developing systolic dysfunction and a poor prognosis in hypertrophic cardiomyopathy (HCM) patients is unknown., We aimed to assess risk factors for the development of end-stage (ES) heart failure (HF) (ejection fraction < 50%) and compare the prognosis of different HF phenotypes., This retrospective study was conducted on patients with HCM in China between January 2009 and February 2023. Patients were stratified into three different groups: HCM-non-HF, HCM-HFpEF and HCM-heart failure with reduced ejection fraction (HCM-HFrEF). The primary outcome was a composite of major adverse cardiac events (MACEs), including all-cause deaths, HF hospitalization, sudden cardiac death and ventricular tachycardia., Of 3,620 HCM patients enrolled, 1,553 (42.9%) had non-HF, 1,666 (46.0%) had HFpEF, and 579 patients (11.1%) had HFrEF at baseline. During the median follow-up period of 4.0 years (IQR 1.4-9.4 years), patients with HCM-HFpEF exhibited a higher incidence of ES-HF than those with HCM-non-HF (12.4% vs. 2.7%, P < 0.001). HFpEF was an independent risk factor for ES-HF development (HR 3.84, 2.54-5.80, P < 0.001). MACEs occurred in 26.9% with a higher incidence in HCM-HFpEF than HCM-non-HF (36.6% vs 12.2%, P < 0.001). HFpEF was an independent predictor of MACEs (HR 2.13, 1.75-2.59, P < 0.001)., HFpEF is common in HCM. Compared to non-HF, it increases the risk of LVEF decline and poor prognosis. It may aid in risk stratification and need close echocardiography follow-up.
资助项目	Wenzhou Science Technology Bureau Foundation[Y20220081];Wenzhou Science Technology Bureau Foundation[2022Y0726]
出版者	SPRINGER HEIDELBERG
ISSN	1861-0684
EISSN	1861-0692
卷号	113 期号:5 页码:761-769
DOI	10.1007/s00392-023-02371-5
页数	9
WOS类目	Cardiac & Cardiovascular Systems
WOS研究方向	Cardiovascular System & Cardiology
WOS记录号	WOS:001140142700001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2024-01
URL	查看原文
PubMed ID	38197895
SCOPUSEID	2-s2.0-85181947396
通讯作者地址	[Zhou, Xiao-Dong]Department of Cardiovascular Medicine,The Heart Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Cardiology and Cardiovascular Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/205883
专题	附属第一医院卓越中心_老年研究院
通讯作者	Zhou, Xiao-Dong
作者单位	1.Medical Care Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Nanbaixiang,325100,China; 2.Institute of Aging,Key Laboratory of Alzheimer’s Disease of Zhejiang Province,Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Information,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 4.Department of Cardiovascular Medicine,The Heart Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 5.Division of Cardiovascular Medicine,Department of Medicine,University of Minnesota Medical School,Minneapolis,United States
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 温州医科大学
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Qin-Fen,Hu, Jiandong,Hu, Jie,et al. Clinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction[J]. Clinical research in cardiology : official journal of the German Cardiac Society,2024,113(5):761-769.
APA	Chen, Qin-Fen., Hu, Jiandong., Hu, Jie., Nijjar, Prabhjot S.., Xu, Jiahui., ... & Zhou, Xiao-Dong. (2024). Clinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction. Clinical research in cardiology : official journal of the German Cardiac Society, 113(5), 761-769.
MLA	Chen, Qin-Fen,et al."Clinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction".Clinical research in cardiology : official journal of the German Cardiac Society 113.5(2024):761-769.