A Population-Based and Clinical Cohort Validation of the Novel Consensus Definition of Metabolic Hyperferritinemia

doi:10.1210/clinem/dgad749

科研成果详情

题名	A Population-Based and Clinical Cohort Validation of the Novel Consensus Definition of Metabolic Hyperferritinemia
作者	Liu, Wen-Yue1,2; Lian, Li-You3,4,5; Zhang, Huai6; Chen, Sui-Dan7; Jin, Xin-Zhe 8; Zhang, Ni3,4,5; Ye, Chen-Hui3,4,5; Chen, Wen-Ying3,4,5; Bee, George Goh Boon 9; Wang, Fu-Di 10,11; Miele, Luca ; Corradini, Elena 13,14,15; Valenti, Luca 12,16,17,18,19,21; Zheng, Ming-Hua3,4,5,20
发表日期	2023-12-20
发表期刊	JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access ; Journal Article
关键词	metabolic hyperferritinemia metabolic dysfunction-associated fatty liver disease metabolic syndrome iron overload Iron overload Metabolic dysfunction-associated fatty liver disease Metabolic hyperferritinemia Metabolic syndrome
其他关键词	TYPE-2 DIABETES-MELLITUS ; FATTY LIVER-DISEASE ; SERUM FERRITIN ; INSULIN-RESISTANCE ; IRON DEPLETION ; HEART-FAILURE ; METAANALYSIS ; SARCOPENIA ; FIBROSIS ; RISK
摘要	Context: There is limited data on the clinical significance of metabolic hyperferritinemia (MHF) based on the most recent consensus.Objective: We aimed to validate the clinical outcomes of MHF in the general population and patients with biopsy-proven metabolic dysfunction-associated fatty liver disease (MAFLD).Methods: The NHANES database and PERSONS cohort were included. MHF was defined as elevated serum ferritin with metabolic dysfunction (MD) and stratified into different grades according to ferritin (grade 1: 200 [females]/300 [males]-550 ng/mL; grade 2: 550-1000 ng/mL; grade 3: >1000 ng/mL). The clinical outcomes, including all-cause death, comorbidities, and liver histology, were compared between non-MHF and MHF in adjusted models.Results: In NHANES, compared with non-MHF with MD, MHF was related to higher risks of advanced fibrosis (P = .036), elevated albumin-creatinine ratio (UACR, P = .001), and sarcopenia (P = .013). Although the association between all grades of MHF and mortality was insignificant (P = .122), grades 2/3 was associated with increased mortality (P = .029). When comparing with non-MHF without MD, the harmful effects of MHF were more significant in mortality (P < .001), elevated UACR (P < .001), cardiovascular disease (P = .028), and sarcopenia (P < .001). In the PERSONS cohort, MHF was associated with more advanced grades of steatosis (P < .001), lobular inflammation (P < .001), advanced fibrosis (P = .017), and more severe hepatocellular iron deposition (P < .001).Conclusion: Both in the general population and in at-risk individuals with MAFLD, MHF was related with poorer clinical outcomes.
资助项目	National Natural Science Foundation of China [82070588]; Project of New Century 551 Talent Nurturing in Wenzhou
出版者	ENDOCRINE SOC
ISSN	0021-972X
EISSN	1945-7197
卷号	109 期号:6 页码:1540-1549
DOI	10.1210/clinem/dgad749
页数	10
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001139669200001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-12
URL	查看原文
PubMed ID	38124275
SCOPUSEID	2-s2.0-85193559123
通讯作者地址	[Zheng, Ming-Hua]Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, 2 Fuxue Lane, Wenzhou 325000, Peoples R China. ; [Valenti, Luca]Univ Milan, Dept Pathophysiol & Transplantat, Via Festa Perdono 7, I-20121 Milan, Italy.
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Biochemistry;Endocrinology;Clinical Biochemistry;Biochemistry (medical)
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/205251
专题	附属第一医院_内分泌科温州医科大学附属第一医院附属第一医院_病理科附属第一医院_检验科
通讯作者	Valenti, Luca; Zheng, Ming-Hua
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou Key Lab Diabet Res, Wenzhou 325000, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, Wenzhou 325000, Peoples R China; 4.Wenzhou Med Univ, Inst Hepatol, Wenzhou 325000, Peoples R China; 5.Key Lab Diag & Treatment Dev Chron Liver Dis, Wenzhou, Zhejiang, Peoples R China; 6.Wenzhou Med Univ, Affiliated Hosp 1, Biostat & Med Qual Management Off, Wenzhou 325000, Peoples R China; 7.Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou 325000, Peoples R China; 8.Wenzhou Med Univ, Affiliated Hosp 1, Dept Lab, Wenzhou 325000, Peoples R China; 9.Singapore Gen Hosp, Dept Gastroenterol & Hepatol, Singapore 169608, Singapore; 10.Zhejiang Univ, Affiliated Hosp 4, Sch Publ Hlth, Sch Med, Hangzhou 310000, Peoples R China; 11.Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Sch Publ Hlth,Basic Med Sci, Hengyang 421001, Peoples R China; 12.Univ Cattolica Roma, Fdn Policlin A Gemelli IRCCS, Dept Internal Med Med & Surg Sci, I-00168 Rome, Italy; 13.Univ Modena & Reggio Emilia, Dept Med & Surg Sci, I-41100 Modena, Italy; 14.Azienda Osped Univ Modena Policlin, Internal Med, I-41100 Modena, Italy; 15.Azienda Osped Univ Modena Policlin, Ctr Hemochromatosis & Hereditary Liver Dis, I-41100 Modena, Italy; 16.Univ Milan, Dept Pathophysiol & Transplantat, I-20121 Milan, Italy; 17.Fdn IRCCS Ca Granda Osped Maggiore Policlin Milano, Biol Resource Ctr, I-20121 Milan, Italy; 18.Fdn IRCCS Ca Granda Osped Maggiore Policlin Milano, Precis Med Lab, I-20121 Milan, Italy; 19.Fdn IRCCS Ca Granda Osped Maggiore Policlin Milano, Dept Transfus Med, I-20121 Milan, Italy; 20.Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, 2 Fuxue Lane, Wenzhou 325000, Peoples R China; 21.Univ Milan, Dept Pathophysiol & Transplantat, Via Festa Perdono 7, I-20121 Milan, Italy
第一作者单位	附属第一医院_内分泌科; 附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院_内分泌科
推荐引用方式 GB/T 7714	Liu, Wen-Yue,Lian, Li-You,Zhang, Huai,et al. A Population-Based and Clinical Cohort Validation of the Novel Consensus Definition of Metabolic Hyperferritinemia[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2023,109(6):1540-1549.
APA	Liu, Wen-Yue., Lian, Li-You., Zhang, Huai., Chen, Sui-Dan., Jin, Xin-Zhe., ... & Zheng, Ming-Hua. (2023). A Population-Based and Clinical Cohort Validation of the Novel Consensus Definition of Metabolic Hyperferritinemia. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 109(6), 1540-1549.
MLA	Liu, Wen-Yue,et al."A Population-Based and Clinical Cohort Validation of the Novel Consensus Definition of Metabolic Hyperferritinemia".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 109.6(2023):1540-1549.