The genetic source tracking of human urinary exosomes

doi:10.1073/pnas.2108876118j1of3

科研成果详情

题名	The genetic source tracking of human urinary exosomes
作者	Zhu, Qingfu1; Cheng, Liming 2; Deng, Chunyu 3; Huang, Liu 4; Li, Jiaoyuan 2; Wang, Yong 5; Li, Meng 5; Yang, Qinsi 5; Dong, Xianjun 6; Su, Jianzhong1,5; Lee, Luke P.7,8,9,10; Liu, Fei1,5
发表日期	2021-10-26
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	exosome origin RNA sequencing cancer diagnosis biomarker discovery
其他关键词	EXTRACELLULAR VESICLES
摘要	The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine.
资助项目	Zhenan Technology City Research Fund; Ministry of Health Research Fund for Medical Sciences [WKJ-ZJ-1910]; Wenzhou Medical University [89218012]; Wenzhou Institute, University of Chinese Academy of Sciences [WIBEZD2017006-05]; Zhejiang Provincial [WKJ-ZJ-1910]
出版者	NATL ACAD SCIENCES
出版地	WASHINGTON
ISSN	0027-8424
EISSN	1091-6490
卷号	118 期号:43
DOI	10.1073/pnas.2108876118j1of3
页数	3
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000715115300018
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	34663731
SCOPUSEID	2-s2.0-85117375417
自科自定义期刊分类	T3(A)类
通讯作者地址	[Lee, Luke P.]Renal Division and Division of Engineering in Medicine,Department of Medicine,Brigham and Women’s Hospital,Harvard Medical School,Boston,02115,United States ; [Liu, Fei]Eye Hospital,School of Ophthalmology and Optometry,School of Biomedical Engineering,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Multidisciplinary
TOP期刊	TOP期刊
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20504
专题	温州医科大学
通讯作者	Lee, Luke P.; Liu, Fei
作者单位	1.Eye Hospital,School of Ophthalmology and Optometry,School of Biomedical Engineering,Wenzhou Medical University,Wenzhou,325035,China; 2.Department of Laboratory Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China; 3.School of Life Science and Technology,Harbin Institute of Technology,Harbin,150080,China; 4.Department of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China; 5.Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,325001,China; 6.Genomics and Bioinformatics Hub,Precision Neurology Program,Department of Neurology,Brigham and Women's Hospital,Harvard Medical School,Boston,02115,United States; 7.Renal Division and Division of Engineering in Medicine,Department of Medicine,Brigham and Women’s Hospital,Harvard Medical School,Boston,02115,United States; 8.Department of Bioengineering,University of California,Berkeley,94720,United States; 9.Department of Electrical Engineering and Computer Science,University of California,Berkeley,94720,United States; 10.Institute of Quantum Biophysics,Department of Biophysics,Sungkyunkwan University,Gyeonggi-do,Suwon,16419,South Korea
推荐引用方式 GB/T 7714	Zhu, Qingfu,Cheng, Liming,Deng, Chunyu,et al. The genetic source tracking of human urinary exosomes[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2021,118(43).
APA	Zhu, Qingfu., Cheng, Liming., Deng, Chunyu., Huang, Liu., Li, Jiaoyuan., ... & Liu, Fei. (2021). The genetic source tracking of human urinary exosomes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(43).
MLA	Zhu, Qingfu,et al."The genetic source tracking of human urinary exosomes".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118.43(2021).