Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China

doi:10.1097/01.CCM.0000284492.30800.00

科研成果详情

题名	Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China
作者	Cheng, Baoli ; Xie, Guohao ; Yao, ShangLong ; Wu, Xinmin ; Guo, Qulian ; Gu, Miaoning ; Fang, Qiang ; Xu, Qiuping ; Wang, Dongxin ; Jin, Yuhong ; Yuan, ShiYing ; Wang, Junlu ; Du, Zhaohui ; Sun, Yunbo ; Fang, XiangMing
发表期刊	CRITICAL CARE MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	epidemiology severe sepsis critically ill surgical patients multicenter study
其他关键词	INTENSIVE-CARE UNITS ; ORGAN FAILURE ; INFECTION ; SCORE
摘要	Objectives: To determine the occurrence rate, outcomes, and the characteristics of severe sepsis in surgical intensive care units in multiple medical centers within China and to assess the cost and resource use of severe sepsis in China. Design and Setting: Prospective, observational study of surgical intensive care unit patients at ten university hospitals in six provinces in China. Patients: All adult admissions in studied intensive care units from December 1, 2004, to November 30, 2005. Interventions. None. Measurements and Main Results. The criteria of severe sepsis were based on the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definition. Analysis of data from 3,665 intensive care unit admissions identified 318 (8.68%) cases of severe sepsis, 64.8% of which were men. The median age (interquartile range) of patients with severe sepsis was 64 (47-74) yrs. Microbes had been isolated from 228 (71.7%) patients, including 171 (53.8%) with Gram-negative bacteria and 146 (45.9%) with Gram-positive bacteria. A total of 90 (22.0%) patients had invasive fungal infection, 20 (6.3%) of which had fungemia. The abdomen was the most common site of infections (72.3%), followed by lung (52.8%). The overall hospital mortality of severe sepsis was 48.7%. Risk factors for hospital mortality included age, chronic comorbidity of malignant neoplasm, Gram-positive bacterial infection, invasive fungal infection, admission Acute Physiology Score, and admission Sequential Organ Failure Assessment score of respiratory dysfunction and cardiovascular dysfunction. The median Therapeutic Intervention Scoring System-28 score was 43 (38-49). The mean hospital cost was $11,390 per patient and $502 per patient per day. Conclusions, Severe sepsis is a common, expensive, and frequently fatal syndrome in critically ill surgical patients in China. Other than the microbiological patterns, the incidence, mortality, and major characteristics of severe sepsis in Chinese surgical intensive care units are close to those documented in developed countries.
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0090-3493
EISSN	1530-0293
卷号	35 期号:11 页码:2538-2546
DOI	10.1097/01.CCM.0000284492.30800.00
WOS类目	Critical Care Medicine
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000250423500009
收录类别	SCIE ; SCOPUS
发表日期	2007-11
URL	查看原文
Scopus记录号	2-s2.0-39049165161
引用统计	被引频次：202[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20415
专题	附属第一医院
通讯作者	Cheng, Baoli
作者单位	1.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Anesthesiol Crit Care Unit, Hangzhou, Peoples R China; 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Anesthesiol & Intens Care Unit, Wuhan 430074, Peoples R China; 3.Peking Univ, Sch Med, Affiliated Hosp 1, Dept Anesthesiol & Intens Care Unit, Beijing, Peoples R China; 4.Cent S Univ, Xiangya Med Coll, Xiangya Hosp, Dept Anesthesiol & Intens Care Unit, Changsha, Peoples R China; 5.S Med Univ, S Hosp, Dept Anesthesiol & Intens Care Unit, Guangzhou, Guangdong, Peoples R China; 6.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Intens Care Unit, Hangzhou 310027, Peoples R China; 7.Ningbo Univ, Sch Med, Lihuili Hosp, Intens Care Unit, Ningbo, Peoples R China; 8.Wuhan Univ, Sch Med, Zhongnan Hosp, Intens Care Unit, Wuhan, Peoples R China; 9.Wenzhou Med Coll, Affiliated Hosp 1, Dept Anesthesiol, Wenzhou, Peoples R China; 10.Qingdao Univ Hosp, Sch Med, Dept Anesthesiol, Intens Care Unit, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Baoli,Xie, Guohao,Yao, ShangLong,et al. Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China[J]. CRITICAL CARE MEDICINE,2007,35(11):2538-2546.
APA	Cheng, Baoli., Xie, Guohao., Yao, ShangLong., Wu, Xinmin., Guo, Qulian., ... & Fang, XiangMing. (2007). Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China. CRITICAL CARE MEDICINE, 35(11), 2538-2546.
MLA	Cheng, Baoli,et al."Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China".CRITICAL CARE MEDICINE 35.11(2007):2538-2546.