Serum alkaline phosphatase, a risk factor for non-alcoholic fatty liver, but only for women in their 30s and 40s: evidence from a large cohort study

doi:10.1080/17474124.2017.1283984

科研成果详情

题名	Serum alkaline phosphatase, a risk factor for non-alcoholic fatty liver, but only for women in their 30s and 40s: evidence from a large cohort study
作者	Zhou, Yu-Jie 1,2; Zou, Hai 3; Zheng, Ji-Na 1,2; Zou, Tian-Tian 1,4; Vitale, Alessandro 5; Miele, Luca 6,7; Van Poucke, Sven 8; Liu, Wen-Yue9; Shen, Shengrong 10; Zhang, Dong-Chu 11; Shi, Ke-Qing1,12; Zheng, Ming-Hua1,12
发表日期	2017-03
发表期刊	EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Non-alcoholic fatty liver alkaline phosphatase age factors sex factors risk factor
其他关键词	HEMODIALYSIS-PATIENTS ; CHINESE ADULTS ; BONE TURNOVER ; NORMAL RANGE ; DISEASE ; PREVALENCE ; PLASMA
摘要	Background: Several risk factors are able to predict non-alcoholic fatty liver (NAFL) development, but the predictive value of serum alkaline phosphatase (ALP) remains uncertain. Our aim is to investigate the association between serum ALP levels and NAFL.Methods: 21,331 NAFL-free subjects were included. Sex-specific ALP quartiles (Q1 to Q4) were defined. With Q1 used as reference, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated across each quartile.Results: After adjusting for confounding variables, values in Q2, Q3 and Q4 had HRs (95%CIs) of 1.16 (0.94-1.43), 1.38 (1.13-1.69), 1.51 (1.24-1.83) in females and 0.99 (0.90-1.09), 1.04 (0.95-1.14), 0.96 (0.87-1.05) in males, respectively. A subgroup analysis of age factors in females, from Q2 to Q4, adjusted HRs (95%CIs) were 1.31 (0.81-1.99), 1.86 (1.23-2.81), 2.44 (1.60-3.71) in their 30s, 1.13 (0.83-1.54), 1.17 (0.85-1.62), 1.65 (1.22-2.25) in their 40s, and 0.95 (0.51-1.78), 0.91 (0.52-1.62), 0.89 (0.53-1.52) in their 50s.Conclusions: Higher serum ALP levels are considered a significant predictor for NAFL development in females aged 30 to 50.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500665]; Scientific Research Foundation of Wenzhou [Y20160223]; High Level Creative Talents from Department of Public Health in Zhejiang Province; Project of New Century 551 Talent Nurturing in Wenzhou
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	1747-4124
EISSN	1747-4132
卷号	11 期号:3 页码:269-276
DOI	10.1080/17474124.2017.1283984
页数	8
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000395088100009
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28095261
SCOPUSEID	2-s2.0-85010638959
通讯作者地址	[Zheng, Ming-Hua]Department of Hepatology,Liver Research Center,the First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China
Scopus学科分类	Hepatology;Gastroenterology
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20332
专题	第一临床医学院（信息与工程学院）、附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院附属第一医院_内分泌科
通讯作者	Zheng, Ming-Hua
作者单位	1.Department of Hepatology,Liver Research Center,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China; 3.Department of Cardiology,Zhejiang Provincial People’s Hospital,Hangzhou,China; 4.School of the Second Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China; 5.Department of Surgery,Oncology and Gastroenterology,University of Padua,Padua,Italy; 6.Institute of Internal Medicine,Catholic University of Rome,Rome,Italy; 7.Gastroenterology Area,Fondazione Policlinico Gemelli,Rome,Italy; 8.Department of Anesthesiology,Critical Care,Emergency Medicine and Pain Therapy,Ziekenhuis Oost-Limburg,Genk,Belgium; 9.Department of Endocrinology,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 10.Department of Food Science & Nutrition,Zhejiang University,Hangzhou,China; 11.Wenzhou Medical Center,Wenzhou People’s Hospital,Wenzhou,China; 12.Institute of Hepatology,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 温州医科大学
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhou, Yu-Jie,Zou, Hai,Zheng, Ji-Na,et al. Serum alkaline phosphatase, a risk factor for non-alcoholic fatty liver, but only for women in their 30s and 40s: evidence from a large cohort study[J]. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY,2017,11(3):269-276.
APA	Zhou, Yu-Jie., Zou, Hai., Zheng, Ji-Na., Zou, Tian-Tian., Vitale, Alessandro., ... & Zheng, Ming-Hua. (2017). Serum alkaline phosphatase, a risk factor for non-alcoholic fatty liver, but only for women in their 30s and 40s: evidence from a large cohort study. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 11(3), 269-276.
MLA	Zhou, Yu-Jie,et al."Serum alkaline phosphatase, a risk factor for non-alcoholic fatty liver, but only for women in their 30s and 40s: evidence from a large cohort study".EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY 11.3(2017):269-276.