Temperature Sensor TRPV1 Regulates Pain

doi:10.16476/j.pibb.2021.0303

科研成果详情

题名	Temperature Sensor TRPV1 Regulates Pain
作者	Wu Yi-Qing 1; Tong Zhi-Qian1; Wan You 2
发表日期	2021-12
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 影响因子和分区
语种	中文
原始文献类型	Review
关键词	TRPV1 cancer pain inflammation pain neuropathic pain peripheral sensitization central sensitization
其他关键词	DORSAL-ROOT GANGLION ; VISCERAL PAIN ; CAPSAICIN RECEPTOR ; RAT MODEL ; ELECTROPHYSIOLOGICAL PROPERTIES ; CENTRAL SENSITIZATION ; NEUROPATHIC PAIN ; UP-REGULATION ; CANCER PAIN ; ION-CHANNEL
摘要	The 2021 Nobel Prize in physiology or medicine was awarded to David Julius and Ardem Patapoutian, based on the outstanding contributions in temperature receptors TRPV1 and tactile receptors PIEZO1/PIEZO2, respectively. They elucidated the mechanisms underlying how the human nervous system senses cold/heat and mechanical stimulation, which contributes to the development of drugs for long-term pain. This article reviews David Julius' pioneering work on TRPV1 which can be activated by capsaicin, heat (>43 degrees C), H+ (pH<6.0), and the critical roles of TRPV1 participating in cancer pain, chronic inflammatory pain, neuropathic pain, and visceral pain by inducing peripheral and/or central sensitization.
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
出版地	BEIJING
ISSN	1000-3282
卷号	48 期号:12 页码:1392-1397
DOI	10.16476/j.pibb.2021.0303
页数	6
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000757110800002
收录类别	SCIE
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2022
专题	卓越中心_老年研究院
通讯作者	Tong Zhi-Qian
作者单位	1.Wenzhou Med Univ, Key Lab Alzheimers Dis Zhejiang Prov, Sch Mental Hlth, Inst Aging, Wenzhou 325035, Peoples R China; 2.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
第一作者单位	卓越中心_老年研究院
第一作者的第一单位	卓越中心_老年研究院
推荐引用方式 GB/T 7714	Wu Yi-Qing,Tong Zhi-Qian,Wan You. Temperature Sensor TRPV1 Regulates Pain[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2021,48(12):1392-1397.
APA	Wu Yi-Qing, Tong Zhi-Qian, & Wan You. (2021). Temperature Sensor TRPV1 Regulates Pain. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 48(12), 1392-1397.
MLA	Wu Yi-Qing,et al."Temperature Sensor TRPV1 Regulates Pain".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 48.12(2021):1392-1397.

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