科研成果详情

题名MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7
作者
发表日期2015-09-08
发表期刊ONCOTARGET   影响因子和分区
语种英语
原始文献类型Article
关键词miR-224 lung cancer caspase-3 caspase-7
其他关键词HEPATOCELLULAR-CARCINOMA ; PROSTATE-CANCER ; DOWN-REGULATION ; BREAST-CANCER ; UP-REGULATION ; EXPRESSION ; APOPTOSIS ; ACTIVATION ; MUTATIONS ; MECHANISM
摘要We recently reported that miR-224 was significantly up-regulated in non-small cell lung cancer (NSCLC) tissues, in particular in resected NSCLC metastasis. We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4. However, the biological functions of miR-224 in NSCLC are controversial and underlying mechanisms of miR-224 in the progression and metastasis of lung cancer remain to be further explored. Here we report that caspase3 (CASP3) and caspase7 (CASP7) are previously unidentified targets of miR-224 in NSCLC, and that miR-224 promotes lung cancer cells proliferation and migration in part by directly targeting CASP7 and down-regulating its expression. In addition, miR-224 attenuated TNF-alpha induced apoptosis by direct targeting of CASP3 resulting in reduction of cleaved PARP1 expression in lung cancer cells. Furthermore, the expression of miR-224 negatively correlates with the expression of CASP7 and CASP3 in tissue samples from patients with lung cancer. Finally, we found that activated NF kappa B signaling is involved in the regulation of miR-224 expression in lung cancer. Our study provides new insight in understanding of oncogenic role of miR-224 in the lung cancer pathogenesis and suggests that NF-kappa B/miR-224/CASP3, 7 pathway could be a putative therapeutic target in lung cancer.
资助项目National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [U01 CA166905, U01 CA152758]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [U01CA166905, U01CA152758] Funding Source: NIH RePORTER
出版者IMPACT JOURNALS LLC
出版地ORCHARD PARK
ISSN1949-2553
EISSN1949-2553
卷号6期号:26页码:21802-21815
DOI10.18632/oncotarget.5224
页数14
WOS类目Oncology ; Cell Biology
WOS研究方向Oncology ; Cell Biology
WOS记录号WOS:000362954800021
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID26307684
PMC记录号PMC4673127
SCOPUSEID2-s2.0-84941241946
通讯作者地址[Croce, Carlo M.]Department of Molecular Virology,Immunology and Medical Genetics,Comprehensive Cancer Center,The Ohio State University,Columbus,United States
Scopus学科分类Oncology
引用统计
被引频次:63[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/20185
专题药学院(分析测试中心)
其他_附属舟山医院(舟山医院)
通讯作者Croce, Carlo M.
作者单位
1.Department of Molecular Virology,Immunology and Medical Genetics,Comprehensive Cancer Center,The Ohio State University,Columbus,United States;
2.Department of Molecular and Cellular Oncology,The University of Texas MD Anderson Cancer Center,Houston,United States;
3.Department of Medicine (DIMED),University of Padua,Padua,Italy;
4.Chemical Biology Research Center,School of Pharmaceutical Sciences,Lung Cancer Research Center,The Zhoushan Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China;
5.Department of Radiation Oncology,Comprehensive Cancer Center,The Ohio State University,Columbus,United States;
6.Applied Research on Cancer Network (ARC-NET) Research Centre,University of Verona,Verona,Italy;
7.Department of Anesthesiology,Wexner Medical Center,The Ohio State University,Columbus,United States;
8.Division of Thoracic Surgery,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Collaborative Innovation Center of Biotherapy,Chengdu,China;
9.Department of Pathology and Diagnostics,University of Verona,Verona,Italy;
10.Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou, Zhejiang,China;
11.Department of Cardio-Thoracic Surgery,Lung Cancer Research Center,Zhoushan Hospital of Wenzhou Medical University,Zhoushan, Zhejiang,China
第一作者单位药学院(分析测试中心);  附属舟山医院(舟山医院);  生物有机与药物化学研究中心
推荐引用方式
GB/T 7714
Cui, Ri,Kim, Taewan,Fassan, Matteo,et al. MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7[J]. ONCOTARGET,2015,6(26):21802-21815.
APA Cui, Ri., Kim, Taewan., Fassan, Matteo., Meng, Wei., Sun, Hui-Lung., ... & Croce, Carlo M.. (2015). MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7. ONCOTARGET, 6(26), 21802-21815.
MLA Cui, Ri,et al."MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7".ONCOTARGET 6.26(2015):21802-21815.

条目包含的文件

条目无相关文件。
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Cui, Ri]的文章
[Kim, Taewan]的文章
[Fassan, Matteo]的文章
百度学术
百度学术中相似的文章
[Cui, Ri]的文章
[Kim, Taewan]的文章
[Fassan, Matteo]的文章
必应学术
必应学术中相似的文章
[Cui, Ri]的文章
[Kim, Taewan]的文章
[Fassan, Matteo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。