Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart

doi:10.1172/JCI38723

科研成果详情

题名	Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart
作者	Zhou, Bin 1,2,3; Ma, Qing 1,2; Sek, Won Kong 1,2; Hu, Yongwu1,2,4; Campbell, Patrick H.5; McGowan, Francis X.5; Ackerman, Kate G.6; Wu, Bingruo 7; Zhou, Bin 7; Tevosian, Sergei G.8; Pu, William T.1,2,3
发表日期	2009-06
发表期刊	JOURNAL OF CLINICAL INVESTIGATION 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	SMOOTH-MUSCLE-CELLS ; FIBROBLAST GROWTH FACTOR-2 ; EPICARDIUM-DERIVED CELLS ; VENTRAL MORPHOGENESIS ; TRANSCRIPTION FACTORS ; TUBE FORMATION ; GATA4 ; EXPRESSION ; FAILURE ; ANGIOGENESIS
摘要	Aberrant transcriptional regulation contributes to the pathogenesis of both congenital and adult forms of heart disease. While the transcriptional regulator friend of Gata 2 (FOG2) is known to be essential for heart morphogenesis and coronary development, its tissue-specific function has not been previously investigated. Additionally, little is known about the role of FOG2 in the adult heart. Here we used spatiotemporally regulated inactivation of Fog2 to delineate its function in both the embryonic and adult mouse heart. Early cardiomyocyte-restricted loss of Fog2 recapitulated the cardiac and coronary defects of the Fog2 germline murine knockouts. Later cardiomyocyte-restricted loss of Fog2 (Fog2(MC)) did not result in defects in cardiac structure or coronary vessel formation. However, Fog2(MC) adult mice had severely depressed ventricular function and died at 8-14 weeks. Fog2(MC) adult hearts displayed a paucity of coronary vessels, associated with myocardial hypoxia, increased cardiomyocyte apoptosis, and cardiac fibrosis. Induced inactivation of Fog2 in the adult mouse heart resulted in similar phenotypes, as did ablation of the FOG2 interaction with the transcription factor GATA4. Loss of the FOG2 or FOG2-GATA4 interaction altered the expression of a panel of angiogenesis-related genes. Collectively, our data indicate that FOG2 regulates adult heart function and coronary angiogenesis.
资助项目	Harvard Stem Cell Institute; American Heart AssociationAmerican Heart Association; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P50HL074734]; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [K08HL076286, P50HL074734, R01HL095712] Funding Source: NIH RePORTER
出版者	AMER SOC CLINICAL INVESTIGATION INC
出版地	ANN ARBOR
ISSN	0021-9738
EISSN	1558-8238
卷号	119 期号:6 页码:1462-1476
DOI	10.1172/JCI38723
页数	15
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000266601000013
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	19411759
SCOPUSEID	2-s2.0-67651005839
自科自定义期刊分类	T2(B)类
通讯作者地址	[Pu W. T.]Enders 1254,Children's Hospital Boston,300 Longwood Avenue,United States
Scopus学科分类	Medicine (all)
TOP期刊	TOP期刊
引用统计	被引频次：59[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20091
专题	基础医学院（机能实验教学中心）_生物科学系
作者单位	1.Enders 1254,Children's Hospital Boston,300 Longwood Avenue,United States; 2.Department of Genetics,Harvard Medical School,United States; 3.Harvard Stem Cell Institute,Harvard University,United States; 4.Department of Biology,Life Science School,Wenzhou Medical College,China; 5.Department of Anesthesiology, Perioperative and Pain Medicine,Children's Hospital Boston,United States; 6.Department of Pediatrics,Department of Biomedical Genetics,University of Rochester Medical Center,United States; 7.Department of Genetics,Albert Einstein College of Medicine,United States; 8.Department of Genetics,Norris Cotton Cancer Center,Dartmouth Medical School,United States
推荐引用方式 GB/T 7714	Zhou, Bin,Ma, Qing,Sek, Won Kong,et al. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart[J]. JOURNAL OF CLINICAL INVESTIGATION,2009,119(6):1462-1476.
APA	Zhou, Bin., Ma, Qing., Sek, Won Kong., Hu, Yongwu., Campbell, Patrick H.., ... & Pu, William T.. (2009). Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. JOURNAL OF CLINICAL INVESTIGATION, 119(6), 1462-1476.
MLA	Zhou, Bin,et al."Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart".JOURNAL OF CLINICAL INVESTIGATION 119.6(2009):1462-1476.