The NAFL Risk Score: A simple scoring model to predict 4-y risk for non-alcoholic fatty liver

doi:10.1016/j.cca.2017.01.021

科研成果详情

题名	The NAFL Risk Score: A simple scoring model to predict 4-y risk for non-alcoholic fatty liver
作者	Zhou, Yu-Jie 1,2; Zheng, Ji-Na 1,2; Liu, Wen-Yue3; Miele, Luca 4,5; Vitale, Alessandro 6; Van Poucke, Sven 7; Zou, Tian-Tian 1,8; Fang, Dan-Hong9; Shen, Shengrong 10; Zhang, Dong-Chu 11; Zheng, Ming-Hua1,12
发表日期	2017-05
发表期刊	CLINICA CHIMICA ACTA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Non-alcoholic fatty liver Prediction model Risk factors General population
其他关键词	SERUM URIC-ACID ; METABOLIC SYNDROME ; CHINESE ADULTS ; NORMAL RANGE ; DISEASE ; ASSOCIATION ; POPULATION ; EPIDEMIOLOGY ; PERSPECTIVE ; PREVALENCE
摘要	Background: Although several risk factors for non-alcoholic fatty liver (NAFL) have been reported, there are few clinical scores that predict its incidence in the long term. We developed and validate a scoring model for individual prediction of 4-y risk for NAFL Methods: Four-year follow-up data of 8226 initially NAFL-free subjects enrolled for an annual physical examination from Wenzhou Medical Center were analyzed. These subjects are randomly split into the training and the validation cohort. Univariate and multivariable logistic regression models were employed for model development. The selected variables were assigned an integer or half-integer risk score proportional to the estimated coefficient from the logistic model. Risk scores were tested in a validation cohort. We also compared the predictive performance of with that of the NAFLD Index by computing the area under the receiver operating characteristic curve (AUROC). Results: The NAFL Risk Score was developed as 0 to 18 points comprising of BMI, TG x GGT, ALT/AST, LDL-C/HDL-C and UA in both sexes. Comparison of the observed with the estimated incidence of NAFL at both cohorts showed satisfactory precision. In addition, the NAFL Risk Score showed relatively good discriminative power (AUROC = 0.739 for males, 0.823 for females) compared with the NAFLD Index (AUROC = 0.661 for males, 0.729 for females) in these Chinese subjects. Conclusions: We developed and validated the NAFL Risk Score, a new scoring model to predict 4-y risk for NAFL The NAFL Risk Score may be clinically simple and useful for assessing individual risk for NAFL (C) 2017 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500665]; Scientific Research Foundation of Wenzhou [Y20160223]; High Level Creative Talents from Department of Public Health in Zhejiang Province; Project of New Century 551 Talent Nurturing in Wenzhou
出版者	ELSEVIER SCIENCE BV
出版地	AMSTERDAM
ISSN	0009-8981
EISSN	1873-3492
卷号	468 页码:17-24
DOI	10.1016/j.cca.2017.01.021
页数	8
WOS类目	Medical Laboratory Technology
WOS研究方向	Medical Laboratory Technology
WOS记录号	WOS:000403121800004
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28111272
SCOPUSEID	2-s2.0-85012199030
通讯作者地址	[Zheng, Ming-Hua]Department of Hepatology,Liver Research Center,The First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China
Scopus学科分类	Biochemistry;Clinical Biochemistry;Biochemistry (medical)
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20076
专题	第一临床医学院（信息与工程学院）、附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院附属第一医院_内分泌科
通讯作者	Zheng, Ming-Hua
作者单位	1.Department of Hepatology,Liver Research Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China; 3.Department of Endocrinology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Surgery,Oncology and Gastroenterology,University of Padua,Padua,Italy; 5.Institute of Internal Medicine,Catholic University of Rome,Rome,Italy; 6.Gastroenterology Area,Fondazione Policlinico Gemelli,Rome,Italy; 7.Department of Anesthesiology,Critical Care,Emergency Medicine and Pain Therapy,Ziekenhuis Oost-Limburg,Genk,Belgium; 8.School of the Second Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China; 9.Department of Cardiovascular Medicine,The Heart Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 10.Department of Food Science & Nutrition,Zhejiang University,Hangzhou,China; 11.Wenzhou Medical Center,Wenzhou People's Hospital,Wenzhou,China; 12.Institute of Hepatology,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 温州医科大学
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhou, Yu-Jie,Zheng, Ji-Na,Liu, Wen-Yue,et al. The NAFL Risk Score: A simple scoring model to predict 4-y risk for non-alcoholic fatty liver[J]. CLINICA CHIMICA ACTA,2017,468:17-24.
APA	Zhou, Yu-Jie., Zheng, Ji-Na., Liu, Wen-Yue., Miele, Luca., Vitale, Alessandro., ... & Zheng, Ming-Hua. (2017). The NAFL Risk Score: A simple scoring model to predict 4-y risk for non-alcoholic fatty liver. CLINICA CHIMICA ACTA, 468, 17-24.
MLA	Zhou, Yu-Jie,et al."The NAFL Risk Score: A simple scoring model to predict 4-y risk for non-alcoholic fatty liver".CLINICA CHIMICA ACTA 468(2017):17-24.