Efficacy Comparison of 16 Interventions for Myopia Control in Children A Network Meta-analysis

doi:10.1016/j.ophtha.2015.11.010

科研成果详情

题名	Efficacy Comparison of 16 Interventions for Myopia Control in Children A Network Meta-analysis
作者	Huang, Jinhai 1,2; Wen, Daizong 1,3; Wang, Qinmei 1,2; McAlinden, Colm 1,4,5; Flitcroft, Ian 6; Chen, Haisi 1,2; Saw, Seang Mei 7; Chen, Hao 1; Bao, Fangjun 1,2; Zhao, Yune 1,2; Hu, Liang 1,2; Li, Xuexi 3; Gao, Rongrong 1,2; Lu, Weicong 1,2; Du, Yaoqiang 1; Jinag, Zhengxuan 8; Yu, Ayong 1,2; Lian, Hengli9; Jiang, Qiuruo1,2; Yu, Ye 1,2; Qu, Jia 1,2
发表日期	2016-04
发表期刊	OPHTHALMOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	EVIDENCE-BASED UPDATE ; HONG-KONG ; CHILDHOOD MYOPIA ; VISUAL IMPAIRMENT ; CLINICAL-TRIALS ; UNITED-STATES ; PROGRESSION ; METAANALYSIS ; PREVALENCE ; ORTHOKERATOLOGY
摘要	Purpose: To determine the effectiveness of different interventions to slow down the progression of myopia in children. Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov from inception to August 2014. We selected randomized controlled trials (RCTs) involving interventions for controlling the progression of myopia in children with a treatment duration of at least 1 year for analysis. Main Outcome Measures: The primary outcomes were mean annual change in refraction (diopters/year) and mean annual change in axial length (millimeters/year). Results: Thirty RCTs (involving 5422 eyes) were identified. Network meta-analysis showed that in comparison with placebo or single vision spectacle lenses, high-dose atropine (refraction change: 0.68 [0.52-0.84]; axial length change: -0.21 [-0.28 to -0.16]), moderate-dose atropine (refraction change: 0.53 [0.28-0.77]; axial length change: -0.21 [-0.32 to -0.12]), and low-dose atropine (refraction change: 0.53 [0.21-0.85]; axial length change: -0.15 [-0.25 to -0.05]) markedly slowed myopia progression. Pirenzepine (refraction change: 0.29 [0.05-0.52]; axial length change: -0.09 [-0.17 to -0.01]), orthokeratology (axial length change: -0.15 [-0.22 to -0.08]), and peripheral defocus modifying contact lenses (axial length change: -0.11 [-0.20 to -0.03]) showed moderate effects. Progressive addition spectacle lenses (refraction change: 0.14 [0.02-0.26]; axial length change: -0.04 [-0.09 to -0.01]) showed slight effects. Conclusions: This network analysis indicates that a range of interventions can significantly reduce myopia progression when compared with single vision spectacle lenses or placebo. In terms of refraction, atropine, pirenzepine, and progressive addition spectacle lenses were effective. In terms of axial length, atropine, orthokeratology, peripheral defocus modifying contact lenses, pirenzepine, and progressive addition spectacle lenses were effective. The most effective interventions were pharmacologic, that is, muscarinic antagonists such as atropine and pirenzepine. Certain specially designed contact lenses, including orthokeratology and peripheral defocus modifying contact lenses, had moderate effects, whereas specially designed spectacle lenses showed minimal effect. (C) 2016 by the American Academy of Ophthalmology. This is an open access article under the CC BY-NC-ND license.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81300807]; Foundation of Wenzhou City Science & Technology Bureau [J20140014, Y20120176]; Zhejiang Provincial & Ministry of Health Research Fund For Medical Sciences [WKJ-ZJ-1530]; Health Bureau of Zhejiang Province [2016RCB013]; National Science and Technology Major Project [2014ZX09303301]
出版者	ELSEVIER SCIENCE INC
出版地	NEW YORK
ISSN	0161-6420
EISSN	1549-4713
卷号	123 期号:4 页码:697-708
DOI	10.1016/j.ophtha.2015.11.010
页数	12
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
WOS记录号	WOS:000372718300013
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26826749
SCOPUSEID	2-s2.0-84955594621
ESI高被引论文	2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09 ; 2024-11
通讯作者地址	[Qu, Jia]Eye Hospital of Wenzhou Medical University,270 West Xueyuan Rd.,Wenzhou, Zhejiang,325027,China
Scopus学科分类	Ophthalmology
TOP期刊	TOP期刊
引用统计	被引频次：315[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20071
专题	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Qu, Jia
作者单位	1.School of Ophthalmology and Optometry,Wenzhou Medical University,Wenzhou, Zhejiang,China; 2.Key Laboratory of Vision Science,Ministry of Health P.R. China,Wenzhou, Zhejiang,China; 3.Department of Ophthalmology,No.180 Hospital of Chinese PLA,Quanzhou,United States; 4.ABM University Health Board,Swansea,United Kingdom; 5.Flinders University,Adelaide,Australia; 6.Department of Ophthalmology,Children's University Hospital,Dublin,Ireland; 7.Department of Epidemiology and Public Health,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore; 8.Department of Ophthalmology,Second Affiliated Hospital of Anhui Medical University,Hefei, Anhui,China; 9.Department of Biological Statistics,Eye Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Huang, Jinhai,Wen, Daizong,Wang, Qinmei,et al. Efficacy Comparison of 16 Interventions for Myopia Control in Children A Network Meta-analysis[J]. OPHTHALMOLOGY,2016,123(4):697-708.
APA	Huang, Jinhai., Wen, Daizong., Wang, Qinmei., McAlinden, Colm., Flitcroft, Ian., ... & Qu, Jia. (2016). Efficacy Comparison of 16 Interventions for Myopia Control in Children A Network Meta-analysis. OPHTHALMOLOGY, 123(4), 697-708.
MLA	Huang, Jinhai,et al."Efficacy Comparison of 16 Interventions for Myopia Control in Children A Network Meta-analysis".OPHTHALMOLOGY 123.4(2016):697-708.