COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies

doi:10.14218/JCTH.2020.00018

科研成果详情

题名	COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies
作者	Feng, Gong 1; Zheng, Kenneth I.2; Yan, Qin-Qin 1; Rios, Rafael S.2; Targher, Giovanni 3; Byrne, Christopher D.4; Poucke, Sven Van 5; Liu, Wen-Yue6; Zheng, Ming-Hua2,7,8
发表日期	2020
发表期刊	JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	COVID-19 Liver dysfunction SARS-CoV-2
其他关键词	CORONAVIRUS ; WUHAN ; AXIS ; SARS
摘要	The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has attracted increasing worldwide attention. Cases of liver damage or dysfunction (mainly characterized by moderately elevated serum aspartate aminotransferase levels) have been reported among patients with COVID-19. However, it is currently uncertain whether the COVID-19-related liver damage/dysfunction is due mainly to the viral infection per se or other coexisting conditions, such as the use of potentially hepatotoxic drugs and the coexistence of systemic inflammatory response, respiratory distress syndrome-induced hypoxia, and multiple organ dysfunction. Based on the current evidence from case reports and case series, this review article focuses on the demographic and clinical characteristics, potential mechanisms, and treatment options for COVID-19-related liver dysfunction. This review also describes the geographical and demographic distribution of COVID-19-related liver dysfunction, as well as possible underlying mechanisms linking COVID-19 to liver dysfunction, in order to facilitate future drug development, prevention, and control measures for COVID-19.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500665]; High Level Creative Talents from Department of Public Health in Zhejiang Province; Project of New Century 551 Talent Nurturing in Wenzhou; University School of Medicine of Verona, Verona, Italy; Southampton National Institute for Health Research Biomedical Research Centre, UK [IS-BRC-20004]
出版者	XIA & HE PUBLISHING INC
出版地	SUGAR LAND
ISSN	2225-0719
EISSN	2310-8819
卷号	8 期号:1 页码:18-24
DOI	10.14218/JCTH.2020.00018
页数	7
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000528190100004
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32274342
PMC记录号	PMC7132016
SCOPUSEID	2-s2.0-85083997539
ESI热点论文	2021-03
ESI高被引论文	2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07
通讯作者地址	[Zheng, Ming-Hua]NAFLD Research Center,Department of Hepatology,the First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China
Scopus学科分类	Gastroenterology
引用统计	被引频次：216[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19995
专题	附属第一医院
通讯作者	Zheng, Ming-Hua
作者单位	1.Xi’an Medical University,Xi’an,China; 2.NAFLD Research Center,Department of Hepatology,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Section of Endocrinology,Diabetes and Metabolism,Department of Medicine,University and Azienda Ospedaliera Universitaria Integrata of Verona,Verona,Italy; 4.Southampton National Institute for Health Research Biomedical Research Center,University Hospital Southampton,Southampton General Hospital,Southampton,United Kingdom; 5.Ziekenhuis Oost-Limburg,Department of Anesthesiology,Critical Care,Emergency Medicine and Pain Therapy,Genk,Belgium; 6.Department of Endocrinology,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 7.Institute of Hepatology,Wenzhou Medical University,Wenzhou,China; 8.Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province,Wenzhou,China
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Feng, Gong,Zheng, Kenneth I.,Yan, Qin-Qin,et al. COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies[J]. JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY,2020,8(1):18-24.
APA	Feng, Gong., Zheng, Kenneth I.., Yan, Qin-Qin., Rios, Rafael S.., Targher, Giovanni., ... & Zheng, Ming-Hua. (2020). COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies. JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 8(1), 18-24.
MLA	Feng, Gong,et al."COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies".JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY 8.1(2020):18-24.