Caffeine preferentially protects against oxygen-induced retinopathy

doi:10.1096/fj.201601285R

科研成果详情

题名	Caffeine preferentially protects against oxygen-induced retinopathy
作者	Zhang, Shuya1,3,4; Zhou, Rong1,3,4; Li, Bo 1,3,4; Li, Haiyan 1,3,4; Wang, Yanyan1,3,4; Gu, Xuejiao 1,3,4; Tang, Lingyun 1,3,4; Wang, Cun1,3,4; Zhong, Dingjuan 1,3,4; Ge, Yuanyuan 1,3,4; Huo, Yuqing 5,6; Lin, Jing 2,7; Liu, Xiao-Ling1,3,4; Chen, Jiang-Fan1,3,4,8
发表日期	2017-08
发表期刊	FASEB JOURNAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	retinopathy of prematurity adenosine A2A receptor vaso-obliteration neovascularization
其他关键词	ENDOTHELIAL GROWTH-FACTOR ; ADENOSINE RECEPTORS ; RETINAL NEOVASCULARIZATION ; SURVIVAL FACTOR ; VESSEL LOSS ; CELL-DEATH ; PREMATURITY ; MODEL ; BRAIN ; MOUSE
摘要	Retinopathy of prematurity (ROP) is the leading cause of childhood blindness, but current anti-VEGF therapy is concerned with delayed retinal vasculature, eye, and brain development of preterm infants. The clinical observation of reduced ROP severity in premature infants after caffeine treatment for apnea suggests that caffeine may protect against ROP. Here, we demonstrate that caffeine did not interfere with normal retinal vascularization development but selectively protected against oxygen-induced retinopathy (OIR) in mice. Moreover, caffeine attenuated not only hypoxia-induced pathologic angiogenesis, but also hyperoxia-induced vaso-obliteration, which suggests a novel protection window by caffeine. At the hyperoxic phase, caffeine reduced oxygen-induced neural apoptosis by adenosine A(2A) receptor (A(2A)R)-dependent mechanism, as revealed by combined caffeine and A(2A)R-knockout treatment. At the hypoxic phase, caffeine reduced microglial activation and enhanced tip cell formation by A(2A)R-dependent and -independent mechanisms, as combined caffeine and A(2A)R knockout produced additive and nearly full protection against OIR. Together with clinical use of caffeine in neonates, our demonstration of the selective protection against OIR, effective therapeutic window, adenosine receptor mechanisms, and neuroglial involvement provide the direct evidence of the novel effects of caffeine therapy in the prevention and treatment of ROP.
资助项目	Wenzhou Medical University [89211010, 89212012]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81630040, 81600753, 81100672]; Zhejiang Provincial Special Funds [604161241]; Key Laboratory of Vision Science, Ministry of Health, China [601041241]; National Key Basic Research Program of ChinaNational Basic Research Program of China [2012CB910402]; Central Government Special Fund for Local Universities' Development [474091314]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [LY12H12007]; U.S. National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney DiseasesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [DK095862]; NIH National Heart, Lung, and Blood InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [HL095556, HL108922]; Boston University School of Medicine Special Research Fund DTD [4-30-14]
出版者	FEDERATION AMER SOC EXP BIOL
出版地	BETHESDA
ISSN	0892-6638
EISSN	1530-6860
卷号	31 期号:8 页码:3334-3348
DOI	10.1096/fj.201601285R
页数	15
WOS类目	Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS记录号	WOS:000405932400013
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28420694
PMC记录号	PMC6207216
SCOPUSEID	2-s2.0-85026817266
通讯作者地址	[Liu, Xiao-Ling]School of Optometry and Ophthalmology and Eye Hospital,Wenzhou Medical University,270 Xueyuan Rd.,Wenzhou, Zhejiang,China
Scopus学科分类	Biotechnology;Biochemistry;Molecular Biology;Genetics
TOP期刊	TOP期刊
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19906
专题	眼视光学院（生物医学工程学院）、附属眼视光医院_分子生物学实验室第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Liu, Xiao-Ling
作者单位	1.Molecular Neuropharmacology Laboratory,School of Optometry and Ophthalmology,Wenzhou Medical University,Eye Hospital,270 Xueyuan Rd.,Wenzhou, Zhejiang,China; 2.Department of Neonatology,Yuying Children’s Hospital,Wenzhou Medical University,Wenzhou,China; 3.State Key Laboratory Cultivation Base,Key Laboratory of Vision Science,Ministry of Health,Wenzhou,China; 4.Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry,Wenzhou,China; 5.Department of Cellular Biology and Anatomy,Vascular Biology Center,Medical College of Georgia,Augusta University,Augusta,United States; 6.Key Laboratory of Chemical Genomics,Drug Discovery Center,Peking University Shenzhen Graduate School,Shenzhen,China; 7.Department of Pediatrics,Icahn School of Medicine at Mount Sinai,New York,United States; 8.Molecular Neuropharmacology Laboratory,School of Optometry and Ophthalmology,Wenzhou Medical University,270 Xueyuan Rd.,Wenzhou, Zhejiang,China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Zhang, Shuya,Zhou, Rong,Li, Bo,et al. Caffeine preferentially protects against oxygen-induced retinopathy[J]. FASEB JOURNAL,2017,31(8):3334-3348.
APA	Zhang, Shuya., Zhou, Rong., Li, Bo., Li, Haiyan., Wang, Yanyan., ... & Chen, Jiang-Fan. (2017). Caffeine preferentially protects against oxygen-induced retinopathy. FASEB JOURNAL, 31(8), 3334-3348.
MLA	Zhang, Shuya,et al."Caffeine preferentially protects against oxygen-induced retinopathy".FASEB JOURNAL 31.8(2017):3334-3348.