科研成果详情

题名Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system
作者
发表日期2015-12
发表期刊METABOLIC BRAIN DISEASE   影响因子和分区
语种英语
原始文献类型Article
关键词Ferulic acid Piperine Depression Monoamines MAO
其他关键词TAIL SUSPENSION TEST ; TRANS-RESVERATROL ; DEPRESSION ; STRESS ; RATS ; CURCUMIN ; MICE
摘要The lifetime prevalence rate for major depressive disorder (MDD) is approximately 17 % for most developed countries around the world. Dietary polyphenols are currently used as an adjuvant therapy to accelerate the therapeutic efficacy on depression. Ferulic acid (FA) or 4-hydroxy-3-methoxy-cinnamic acid (Fig. 1a) is a main polyphenolic component of Chinese herb Radix Angelicae Sinensis, which is found to have antidepressant-like effects through regulating serotonergic and noradrenergic function. The present study examined the synergistic effect of low doses of FA combined with subthreshold dose of piperine, a bioavailability enhancer, on depression-like behaviors in mice, and investigated the possible mechanism. The administration of FA, even in the highest dose tested, reduced immobility time by 60 % in the tail suspension and forced swimming tests (TST and FST) in mice when compared to control. The maximal antidepressant-like effect of FA was obtained with 200 mg/kg. In addition, piperine only produced a weak antidepressant-like effect in the TST and FST. However, the evidence from the interaction analysis suggested a synergistic effect when low doses of FA were combined with a subthreshold dose of piperine. Further neurochemical evidence such as monoamine levels in the frontal cortex, hippocampus, and hypothalamus and measurements of monoamine oxidase activity also supported a synergistic effect of FA and piperine in the enhancement of monoaminergic function. This finding supports the concept that the combination strategy might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.
资助项目Natural Science Foundation of Ningbo [2012A610256, 2014A610256]; Zhejiang provincial Public Welfare Technology Application Research Plan [2015C33297]; Ministry of Science and Technology Spark Plan [2014GA701011]; Natural Science Foundation of Changzhou [ZD2O1413]; National Institute of General Medical SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [Reed - U54GM104942]; Zhejiang Province Extremely Key Subject Building Funding; Latitudinal project of Wenzhou Medical University [95012011]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [U54GM104942] Funding Source: NIH RePORTER
出版者SPRINGER/PLENUM PUBLISHERS
出版地NEW YORK
ISSN0885-7490
EISSN1573-7365
卷号30期号:6页码:1505-1514
DOI10.1007/s11011-015-9704-y
页数10
WOS类目Endocrinology & Metabolism ; Neurosciences
WOS研究方向Endocrinology & Metabolism ; Neurosciences & Neurology
WOS记录号WOS:000365086600022
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID26220010
PMC记录号PMC4795470
SCOPUSEID2-s2.0-84947019448
通讯作者地址[Pan, Jianchun]Brain Institute,School of Pharmacy,Wenzhou Medical University,Wenzhou,325021,China
Scopus学科分类Biochemistry;Neurology (clinical);Cellular and Molecular Neuroscience
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/19801
专题药学院(分析测试中心)
药学院(分析测试中心)_药学系
通讯作者Pan, Jianchun
作者单位
1.Ningbo college of Health Sciences,Ningbo,325600,China;
2.Brain Institute,School of Pharmacy,Wenzhou Medical University,Wenzhou,325021,China;
3.Department of Pharmacy,The Second Affiliate Hospital,Wenzhou Medical University,Wenzhou,325021,China;
4.Taizhou Institution for Food and Drug Control,Taizhou,318000,China;
5.Pingyang Hospital of Traditional Chinese Medicine,Pingyang,325400,China;
6.Behavioral Neuroscience,Department of Psychology,West Virginia University,Morgantown,26505,United States;
7.Department of Neurosurgery and Neurology,Changzhou Second People’s Hospital,Changzhou,213003,China;
8.Department of Pharmaceutical Sciences,School of Pharmacy and Pharmaceutical Sciences,State University of New York at Buffalo,Buffalo,14214,United States;
9.Department of Neurology,Lianyungang second people’s Hospital,Lianyungang,222023,China
通讯作者单位温州医科大学
推荐引用方式
GB/T 7714
Li, Gaowen,Ruan, Lina,Chen, Ruijie,et al. Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system[J]. METABOLIC BRAIN DISEASE,2015,30(6):1505-1514.
APA Li, Gaowen., Ruan, Lina., Chen, Ruijie., Wang, Renye., Xie, Xupei., ... & Huang, Wu. (2015). Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system. METABOLIC BRAIN DISEASE, 30(6), 1505-1514.
MLA Li, Gaowen,et al."Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system".METABOLIC BRAIN DISEASE 30.6(2015):1505-1514.

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