题名 | Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system |
作者 | |
发表日期 | 2015-12 |
发表期刊 | METABOLIC BRAIN DISEASE 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Ferulic acid Piperine Depression Monoamines MAO |
其他关键词 | TAIL SUSPENSION TEST ; TRANS-RESVERATROL ; DEPRESSION ; STRESS ; RATS ; CURCUMIN ; MICE |
摘要 | The lifetime prevalence rate for major depressive disorder (MDD) is approximately 17 % for most developed countries around the world. Dietary polyphenols are currently used as an adjuvant therapy to accelerate the therapeutic efficacy on depression. Ferulic acid (FA) or 4-hydroxy-3-methoxy-cinnamic acid (Fig. 1a) is a main polyphenolic component of Chinese herb Radix Angelicae Sinensis, which is found to have antidepressant-like effects through regulating serotonergic and noradrenergic function. The present study examined the synergistic effect of low doses of FA combined with subthreshold dose of piperine, a bioavailability enhancer, on depression-like behaviors in mice, and investigated the possible mechanism. The administration of FA, even in the highest dose tested, reduced immobility time by 60 % in the tail suspension and forced swimming tests (TST and FST) in mice when compared to control. The maximal antidepressant-like effect of FA was obtained with 200 mg/kg. In addition, piperine only produced a weak antidepressant-like effect in the TST and FST. However, the evidence from the interaction analysis suggested a synergistic effect when low doses of FA were combined with a subthreshold dose of piperine. Further neurochemical evidence such as monoamine levels in the frontal cortex, hippocampus, and hypothalamus and measurements of monoamine oxidase activity also supported a synergistic effect of FA and piperine in the enhancement of monoaminergic function. This finding supports the concept that the combination strategy might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects. |
资助项目 | Natural Science Foundation of Ningbo [2012A610256, 2014A610256]; Zhejiang provincial Public Welfare Technology Application Research Plan [2015C33297]; Ministry of Science and Technology Spark Plan [2014GA701011]; Natural Science Foundation of Changzhou [ZD2O1413]; National Institute of General Medical SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [Reed - U54GM104942]; Zhejiang Province Extremely Key Subject Building Funding; Latitudinal project of Wenzhou Medical University [95012011]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [U54GM104942] Funding Source: NIH RePORTER |
出版者 | SPRINGER/PLENUM PUBLISHERS |
出版地 | NEW YORK |
ISSN | 0885-7490 |
EISSN | 1573-7365 |
卷号 | 30期号:6页码:1505-1514 |
DOI | 10.1007/s11011-015-9704-y |
页数 | 10 |
WOS类目 | Endocrinology & Metabolism ; Neurosciences |
WOS研究方向 | Endocrinology & Metabolism ; Neurosciences & Neurology |
WOS记录号 | WOS:000365086600022 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 26220010 |
PMC记录号 | PMC4795470 |
SCOPUSEID | 2-s2.0-84947019448 |
通讯作者地址 | [Pan, Jianchun]Brain Institute,School of Pharmacy,Wenzhou Medical University,Wenzhou,325021,China |
Scopus学科分类 | Biochemistry;Neurology (clinical);Cellular and Molecular Neuroscience |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/19801 |
专题 | 药学院(分析测试中心) 药学院(分析测试中心)_药学系 |
通讯作者 | Pan, Jianchun |
作者单位 | 1.Ningbo college of Health Sciences,Ningbo,325600,China; 2.Brain Institute,School of Pharmacy,Wenzhou Medical University,Wenzhou,325021,China; 3.Department of Pharmacy,The Second Affiliate Hospital,Wenzhou Medical University,Wenzhou,325021,China; 4.Taizhou Institution for Food and Drug Control,Taizhou,318000,China; 5.Pingyang Hospital of Traditional Chinese Medicine,Pingyang,325400,China; 6.Behavioral Neuroscience,Department of Psychology,West Virginia University,Morgantown,26505,United States; 7.Department of Neurosurgery and Neurology,Changzhou Second People’s Hospital,Changzhou,213003,China; 8.Department of Pharmaceutical Sciences,School of Pharmacy and Pharmaceutical Sciences,State University of New York at Buffalo,Buffalo,14214,United States; 9.Department of Neurology,Lianyungang second people’s Hospital,Lianyungang,222023,China |
通讯作者单位 | 温州医科大学 |
推荐引用方式 GB/T 7714 | Li, Gaowen,Ruan, Lina,Chen, Ruijie,et al. Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system[J]. METABOLIC BRAIN DISEASE,2015,30(6):1505-1514. |
APA | Li, Gaowen., Ruan, Lina., Chen, Ruijie., Wang, Renye., Xie, Xupei., ... & Huang, Wu. (2015). Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system. METABOLIC BRAIN DISEASE, 30(6), 1505-1514. |
MLA | Li, Gaowen,et al."Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system".METABOLIC BRAIN DISEASE 30.6(2015):1505-1514. |
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