Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

doi:10.1016/j.biomaterials.2016.06.018

科研成果详情

题名	Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer
作者	Zhang, Mingzhen 1,2; Viennois, Emilie 1,2; Prasad, Meena 3,4; Zhang, Yunchen 1,2; Wang, Lixin 1,2,3; Zhang, Zhan 1,2; Han, Moon Kwon 1,2; Xiao, Bo 1,2,5; Xu, Changlong1,2,6; Srinivasan, Shanthi 3,4; Merlin, Didier 1,2,3
发表日期	2016-09
发表期刊	BIOMATERIALS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Edible ginger derived nanoparticles Inflammatory bowel disease Colitis-associated cancer Natural drug delivery system Therapy
其他关键词	CHRONIC INTESTINAL INFLAMMATION ; EXOSOME-LIKE NANOPARTICLES ; ULCERATIVE-COLITIS ; BARRIER FUNCTION ; POLYMERIC NANOPARTICLES ; REDUCE COLITIS ; DRUG-DELIVERY ; PROTECT MICE ; T-CELLS ; COLON
摘要	There is a clinical need for new, more effective treatments for chronic and debilitating inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. In this study, we characterized a specific population of nanoparticles derived from edible ginger (GDNPs 2) and demonstrated their efficient colon targeting following oral administration. GDNPs 2 had an average size of similar to 230 nm and exhibited a negative zeta potential. These nanoparticles contained high levels of lipids, a few proteins, 125 microRNAs (miRNAs), and large amounts of ginger bioactive constituents (6-gingerol and 6-shogaol). We also demonstrated that GDNPs 2 were mainly taken up by intestinal epithelial cells (IECs) and macrophages, and were nontoxic. Using different mouse colitis models, we showed that GDNPs 2 reduced acute colitis, enhanced intestinal repair, and prevented chronic colitis and colitis associated cancer (CAC). 2D-DIGE/MS analyses further identified molecular target candidates of GDNPs 2 involved in these mouse models. Oral administration of GDNPs 2 increased the survival and proliferation of IECs and reduced the pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1 beta), and increased the anti-inflammatory cytokines (IL-10 and IL-22) in colitis models, suggesting that GDNPs 2 has the potential to attenuate damaging factors while promoting the healing effect. In conclusion, GDNPs 2, nanoparticles derived from edible ginger, represent a novel, natural delivery mechanism for improving IBD prevention and treatment with an added benefit of overcoming limitations such as potential toxicity and limited production scale that are common with synthetic nanoparticles. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	Department of Veterans AffairsUS Department of Veterans Affairs [BX002526]; National Institutes of Health of Diabetes and Digestive and KidneyUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [RO1-DK-071594]; Crohn's & Colitis Foundation of America; Department of Veterans AffairsUS Department of Veterans Affairs; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R01DK071594] Funding Source: NIH RePORTER; Veterans AffairsUS Department of Veterans Affairs [I01BX002526] Funding Source: NIH RePORTER
出版者	ELSEVIER SCI LTD
出版地	OXFORD
ISSN	0142-9612
EISSN	1878-5905
卷号	101 页码:321-340
DOI	10.1016/j.biomaterials.2016.06.018
页数	20
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向	Engineering ; Materials Science
WOS记录号	WOS:000379632500029
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20162502511413
EI主题词	Diseases
URL	查看原文
PubMed ID	27318094
PMC记录号	PMC4921206
SCOPUSEID	2-s2.0-84974533498
ESI高被引论文	2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09 ; 2024-11
自科自定义期刊分类	T3(B)类
通讯作者地址	[Zhang, Mingzhen]Center for Diagnostics and Therapeutics,Institute for Biomedical Science,Georgia State University,Atlanta,30303,United States
Scopus学科分类	Biophysics;Bioengineering;Ceramics and Composites;Biomaterials;Mechanics of Materials
TOP期刊	TOP期刊
引用统计	被引频次：258[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19790
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院
通讯作者	Zhang, Mingzhen
作者单位	1.Institute for Biomedical Sciences,Georgia State University,Atlanta,30303,United States; 2.Center for Diagnostics and Therapeutics,Georgia State University,Atlanta,30303,United States; 3.Veterans Affairs Medical Center,Decatur,United States; 4.Emory University,Department of Medicine,United States; 5.Institute for Clean Energy and Advanced Materials,Faculty for Materials and Energy,Southwest University,Chongqing,400715,China; 6.The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325027,China
推荐引用方式 GB/T 7714	Zhang, Mingzhen,Viennois, Emilie,Prasad, Meena,et al. Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer[J]. BIOMATERIALS,2016,101:321-340.
APA	Zhang, Mingzhen., Viennois, Emilie., Prasad, Meena., Zhang, Yunchen., Wang, Lixin., ... & Merlin, Didier. (2016). Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer. BIOMATERIALS, 101, 321-340.
MLA	Zhang, Mingzhen,et al."Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer".BIOMATERIALS 101(2016):321-340.