题名 | Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer |
作者 | |
发表期刊 | BIOMATERIALS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Edible ginger derived nanoparticles Inflammatory bowel disease Colitis-associated cancer Natural drug delivery system Therapy |
其他关键词 | CHRONIC INTESTINAL INFLAMMATION ; EXOSOME-LIKE NANOPARTICLES ; ULCERATIVE-COLITIS ; BARRIER FUNCTION ; POLYMERIC NANOPARTICLES ; REDUCE COLITIS ; DRUG-DELIVERY ; PROTECT MICE ; T-CELLS ; COLON |
摘要 | There is a clinical need for new, more effective treatments for chronic and debilitating inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. In this study, we characterized a specific population of nanoparticles derived from edible ginger (GDNPs 2) and demonstrated their efficient colon targeting following oral administration. GDNPs 2 had an average size of similar to 230 nm and exhibited a negative zeta potential. These nanoparticles contained high levels of lipids, a few proteins, 125 microRNAs (miRNAs), and large amounts of ginger bioactive constituents (6-gingerol and 6-shogaol). We also demonstrated that GDNPs 2 were mainly taken up by intestinal epithelial cells (IECs) and macrophages, and were nontoxic. Using different mouse colitis models, we showed that GDNPs 2 reduced acute colitis, enhanced intestinal repair, and prevented chronic colitis and colitis associated cancer (CAC). 2D-DIGE/MS analyses further identified molecular target candidates of GDNPs 2 involved in these mouse models. Oral administration of GDNPs 2 increased the survival and proliferation of IECs and reduced the pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1 beta), and increased the anti-inflammatory cytokines (IL-10 and IL-22) in colitis models, suggesting that GDNPs 2 has the potential to attenuate damaging factors while promoting the healing effect. In conclusion, GDNPs 2, nanoparticles derived from edible ginger, represent a novel, natural delivery mechanism for improving IBD prevention and treatment with an added benefit of overcoming limitations such as potential toxicity and limited production scale that are common with synthetic nanoparticles. (C) 2016 Elsevier Ltd. All rights reserved. |
资助项目 | Department of Veterans AffairsUS Department of Veterans Affairs [BX002526]; National Institutes of Health of Diabetes and Digestive and KidneyUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [RO1-DK-071594]; Crohn's & Colitis Foundation of America; Department of Veterans AffairsUS Department of Veterans Affairs; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R01DK071594] Funding Source: NIH RePORTER; Veterans AffairsUS Department of Veterans Affairs [I01BX002526] Funding Source: NIH RePORTER |
出版者 | ELSEVIER SCI LTD |
出版地 | OXFORD |
ISSN | 0142-9612 |
EISSN | 1878-5905 |
卷号 | 101页码:321-340 |
DOI | 10.1016/j.biomaterials.2016.06.018 |
WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
WOS研究方向 | Engineering ; Materials Science |
WOS记录号 | WOS:000379632500029 |
收录类别 | SCIE ; PUBMED ; EI ; SCOPUS |
发表日期 | 2016-09 |
EI入藏号 | 20162502511413 |
EI主题词 | Diseases |
URL | 查看原文 |
Pubmed记录号 | 27318094 |
PMC记录号 | PMC4921206 |
Scopus记录号 | 2-s2.0-84974533498 |
ESI高被引论文 | 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 |
自科自定义期刊分类 | T3(B)类 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/19790 |
专题 | 第二临床医学院、附属第二医院、育英儿童医院 |
通讯作者 | Zhang, Mingzhen |
作者单位 | 1.Georgia State Univ, Inst Biomed Sci, Atlanta, GA 30303 USA; 2.Georgia State Univ, Ctr Diagnost & Therapeut, Atlanta, GA 30303 USA; 3.Vet Affairs Med Ctr, Decatur, GA 30033 USA; 4.Emory Univ, Dept Med, Atlanta, GA 30322 USA; 5.Southwest Univ, Fac Mat & Energy, Inst Clean Energy & Adv Mat, Chongqing 400715, Peoples R China; 6.Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou 325027, Peoples R China; 7.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Mingzhen,Viennois, Emilie,Prasad, Meena,et al. Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer[J]. BIOMATERIALS,2016,101:321-340. |
APA | Zhang, Mingzhen., Viennois, Emilie., Prasad, Meena., Zhang, Yunchen., Wang, Lixin., ... & Merlin, Didier. (2016). Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer. BIOMATERIALS, 101, 321-340. |
MLA | Zhang, Mingzhen,et al."Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer".BIOMATERIALS 101(2016):321-340. |
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