miR-126 and miR-126*repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis

doi:10.1038/ncb2690

科研成果详情

题名	*miR-126 and miR-126repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis**
作者	Zhang, Yun 1; Yang, Pengyuan 1,2; Sun, Tao 1; Li, Dong 2; Xu, Xin 1; Rui, Yaocheng 2; Li, Chaoran 3; Chong, Mengyang 1; Ibrahim, Toni 4; Mercatali, Laura 4; Amadori, Dino 4; Lu, Xincheng5; Xie, Dong 6; Li, Qi-Jing 3; Wang, Xiao-Fan 1
发表期刊	NATURE CELL BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	BONE-MARROW ; IN-VITRO ; PROGENITOR CELLS ; TUMOR-GROWTH ; MICRORNAS ; MIGRATION ; MURINE ; DISSEMINATION ; MOBILIZATION ; BIOGENESIS
摘要	The tumour stroma is an active participant during cancer progression. Stromal cells promote tumour progression and metastasis through multiple mechanisms including enhancing tumour invasiveness and angiogenesis, and suppressing immune surveillance. We report here that miR-126/miR-126, a microRNA pair derived from a single precursor, independently suppress the sequential recruitment of mesenchymal stem cells and inflammatory monocytes into the tumour stroma to inhibit lung metastasis by breast tumour cells in a mouse xenograft model. miR-126/miR-126 directly inhibit stromal cell-derived factor-1 alpha (Sdf-1 alpha) expression, and indirectly suppress the expression of chemokine (C-C motif) ligand 2 (Ccl2) by cancer cells in an Sdf-1 alpha-dependent manner. miR-126/miR-126* expression is downregulated in cancer cells by promoter methylation of their host gene Egfl7. These findings determine how this microRNA pair alters the composition of the primary tumour microenvironment to favour breast cancer metastasis, and demonstrate a correlation between miR-126/126* downregulation and poor metastasis-free survival of breast cancer patients.
资助项目	NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [CA151541]; S. G. Komen For The Cure Foundation [KG101633]; American Cancer SocietyAmerican Cancer Society [RSG-10-157-01-LIB]; Ministry of Science and Technology Key Program of China [2012ZX10002009-017]; National Basic Research Program of ChinaNational Basic Research Program of China [2010CB912102]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R01CA151541] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI091878] Funding Source: NIH RePORTER
出版者	NATURE PUBLISHING GROUP
出版地	LONDON
ISSN	1465-7392
EISSN	1476-4679
卷号	15 期号:3 页码:284-294
DOI	10.1038/ncb2690
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:000315844900009
收录类别	SCIE ; SCOPUS
发表日期	2013-03
URL	查看原文
Scopus记录号	2-s2.0-84874629992
自科自定义期刊分类	T2(A)类
引用统计	被引频次：265[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19613
专题	基因组医学研究院
通讯作者	Li, Qi-Jing
作者单位	1.Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA; 2.Second Mil Med Univ, Dept Pharmacol, Shanghai 200433, Peoples R China; 3.Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA; 4.IRCCS Ist Sci Romagnolo Studio & Cura Tumori IRST, Osteoncol & Rare Tumors Ctr, I-47014 Meldola, Italy; 5.Wenzhou Med Coll, Inst Genom Med, Wenzhou 325027, Zhejiang, Peoples R China; 6.Shanghai Inst Biol Sci, Inst Nutr Sci, Mol Oncol Lab, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yun,Yang, Pengyuan,Sun, Tao,et al. miR-126 and miR-126*repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis[J]. NATURE CELL BIOLOGY,2013,15(3):284-294.
APA	Zhang, Yun., Yang, Pengyuan., Sun, Tao., Li, Dong., Xu, Xin., ... & Wang, Xiao-Fan. (2013). miR-126 and miR-126*repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. NATURE CELL BIOLOGY, 15(3), 284-294.
MLA	Zhang, Yun,et al."miR-126 and miR-126*repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis".NATURE CELL BIOLOGY 15.3(2013):284-294.