MATERNAL THYROID-STIMULATING HORMONE LEVEL IN THE FIRST TRIMESTER AND SEX RATIO AT BIRTH

doi:10.4158/EP-2018-0348

科研成果详情

题名	MATERNAL THYROID-STIMULATING HORMONE LEVEL IN THE FIRST TRIMESTER AND SEX RATIO AT BIRTH
作者	Wang, Xiao 1; Sun, Xiaoting 2; Yang, Lili3; Tang, Rong 2; Zhou, Jing 1; Huang, Yanjun1; Pan, Jiexue4; Chen, Xia4; Yang, Haiyan4; Chen, Qianqian 4; Chen, Zimiao5; Mu, Liangshan 4
发表日期	2019-04
发表期刊	ENDOCRINE PRACTICE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	TSH LEVELS ; PREGNANCY ; WOMEN ; ASSOCIATION ; DYSFUNCTION ; MANAGEMENT ; SMOKING ; FETAL ; DIET
摘要	Objective: Few studies have explored the influence of thyroid status on sex ratio at birth, and conclusions are inconsistent. The aim of this study was to determine if there is an association between serum thyroid-stimulating hormone (TSH) level in first trimester and sex ratio at birth. Methods: The study was a retrospective cohort study performed at a tertiary care center. From March 2014 to February 2017, a total of 4,822 women who had thyroid function testing during the first trimester were included. Study population was divided into five groups according to quintile of TSH level (<= 0.60 mIU/L; 0.61 to 1.02 mIU/L; 1.03 to 1.44 mIL/L; 1.45 to 2.13 and >= 2.14 mIU/L). Logistic regression analysis was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of the percentage of male infants across the quintiles, with the lowest quintile as the reference category. Results: Median level of TSH was 1.27 mIU/L in women who delivered a boy, which was significantly higher than that in women who delivered a girl (1.15 mIU/L). After adjusting for age, gravidity, and parity, multivariate logistic analysis found that women in quintiles 3, 4, and 5 all showed significantly higher ORs for delivering a boy than those in quintile 1. In addition, after adjusting for age, gravidity, and parity, serum TSH was significantly associated with likelihood of having a boy (OR, 1.08; 95% CI, 1.03 to 1.13). Conclusion: Maternal TSH level in the first trimester is positively associated with the probability of delivering a male newborn.
出版者	AMER ASSOC CLINICAL ENDOCRINOLOGISTS
出版地	JACKSONVILLE
ISSN	1530-891X
EISSN	1934-2403
卷号	25 期号:4 页码:315-319
DOI	10.4158/EP-2018-0348
页数	5
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000465109200003
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	30995430
SCOPUSEID	2-s2.0-85064733947
通讯作者地址	[Mu, Liangshan]Reproductive Medicine Center,First Affiliated Hospital,Wenzhou Medical University,No. 96 Fuxue Road,Wenzhou,325000,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Endocrinology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19466
专题	附属第一医院_产科附属第二医院第二临床医学院、附属第二医院、育英儿童医院附属第一医院_内分泌科第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心
通讯作者	Mu, Liangshan
作者单位	1.Department of Obstetrics,First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 2.Wenzhou Medical University,Wenzhou,China; 3.Department of Radiology,Second Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 4.Reproductive Medicine Center,First Affiliated Hospital,Wenzhou Medical University,No. 96 Fuxue Road,Wenzhou,325000,China; 5.Department of Endocrinology,First Affiliated Hospital,Wenzhou Medical University,No. 2 Fuxue Road,Wenzhou,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Xiao,Sun, Xiaoting,Yang, Lili,et al. MATERNAL THYROID-STIMULATING HORMONE LEVEL IN THE FIRST TRIMESTER AND SEX RATIO AT BIRTH[J]. ENDOCRINE PRACTICE,2019,25(4):315-319.
APA	Wang, Xiao., Sun, Xiaoting., Yang, Lili., Tang, Rong., Zhou, Jing., ... & Mu, Liangshan. (2019). MATERNAL THYROID-STIMULATING HORMONE LEVEL IN THE FIRST TRIMESTER AND SEX RATIO AT BIRTH. ENDOCRINE PRACTICE, 25(4), 315-319.
MLA	Wang, Xiao,et al."MATERNAL THYROID-STIMULATING HORMONE LEVEL IN THE FIRST TRIMESTER AND SEX RATIO AT BIRTH".ENDOCRINE PRACTICE 25.4(2019):315-319.