The Preoperative Enhanced Degree of Contrast-enhanced CT Images: A Potential Independent Predictor in Gastric Adenocarcinoma Patients After Radical Gastrectomy

doi:10.2147/CMAR.S271879

科研成果详情

题名	The Preoperative Enhanced Degree of Contrast-enhanced CT Images: A Potential Independent Predictor in Gastric Adenocarcinoma Patients After Radical Gastrectomy
作者	Wang, Xinxin 1; Ye, Huajun1; Yan, Ye1; Wu, Jiansheng1; Wang, Na 2; Chen, Mengjun1
发表日期	2020
发表期刊	CANCER MANAGEMENT AND RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	gastric adenocarcinoma radical gastrectomy contrast-enhanced CT overall survival prognosis
其他关键词	MULTIDETECTOR-ROW CT ; COMPUTED-TOMOGRAPHY ; TUMOR ANGIOGENESIS ; PROGNOSTIC-FACTOR ; CANCER ; CLASSIFICATION ; GASTROGRAPHY ; SURGERY
摘要	Aim: To discover the value of contrast-enhanced CT parameters in predicting the prognosis of gastric adenocarcinoma (GAC) patients after radical gastrectomy. Methods: The patients with a clinical diagnosis of GAC were retrospectively enrolled. Two radiologists drew the regions of interest (ROIs) in CT images and measured the CT attenuate value (CAV) in each phase and the corrected CAV (cCAV) in each contrast-enhanced phase. Patients were divided into two groups (high/low-enhancement) according to receiver operating characteristic (ROC) curve. Kaplan-Meier curve and Cox proportional hazards regression analysis were performed to evaluate correlation between prognosis and variables. Subgroup analysis was used to further analyze the prognostic value of variables. Results: In total 435 patients were included. According to ROC curve, the cCAV in delayed phase (DP-cCAV) with maximum AUC and Youden index was chosen. A total of 312 patients (71.7%) entered DP-cCAV(low) group and remaining 123 (28.3%) patients were in DP-cCAV(high) group. According to univariate (high vs low, HR=2.120, p<0.001) and multivariate (high vs low, HR=1.623, p 0.001) Cox regression analysis, the low-enhancement state was considered as an independent protective factor. Subgroup analysis was based on age, maximum diameter of tumor, differentiation, vascular invasion status, and TNM staging. In most subgroups, the overall survival (OS) of DP-cCAV(low) group was overwhelmingly satisfactory (all HR 1, expect TNM stage I, IV and differentiated type subgroups). Conclusion: The prognostic effectiveness of CT parameters as biomarkers for OS in GAC patients treated with radical gastrectomy has potential value.
资助项目	Wenzhou Municipal Sci-Tech Bureau's program [Y20170063]
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1179-1322
卷号	12 页码:11989-11999
DOI	10.2147/CMAR.S271879
页数	11
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000596890400001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33262649
PMC记录号	PMC7695603
SCOPUSEID	2-s2.0-85096500213
通讯作者地址	[Wang, Na]Health Care Center,The First Affiliated Hospital of Wenzhou Medical University,Nan Bai Xiang Street, Ouhai District,Wenzhou,325006,China ; [Chen, Mengjun]Department of Gastroenterology,The First Affiliated Hospital of Wenzhou Medical University,Nan Bai Xiang Street, Ouhai District,Wenzhou,325006,China
Scopus学科分类	Oncology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19451
专题	附属第一医院
通讯作者	Wang, Na; Chen, Mengjun
作者单位	1.Department of Gastroenterology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325006,China; 2.Health Care Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325006,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Xinxin,Ye, Huajun,Yan, Ye,et al. The Preoperative Enhanced Degree of Contrast-enhanced CT Images: A Potential Independent Predictor in Gastric Adenocarcinoma Patients After Radical Gastrectomy[J]. CANCER MANAGEMENT AND RESEARCH,2020,12:11989-11999.
APA	Wang, Xinxin, Ye, Huajun, Yan, Ye, Wu, Jiansheng, Wang, Na, & Chen, Mengjun. (2020). The Preoperative Enhanced Degree of Contrast-enhanced CT Images: A Potential Independent Predictor in Gastric Adenocarcinoma Patients After Radical Gastrectomy. CANCER MANAGEMENT AND RESEARCH, 12, 11989-11999.
MLA	Wang, Xinxin,et al."The Preoperative Enhanced Degree of Contrast-enhanced CT Images: A Potential Independent Predictor in Gastric Adenocarcinoma Patients After Radical Gastrectomy".CANCER MANAGEMENT AND RESEARCH 12(2020):11989-11999.