Curcumin Analogue A501 induces G2/M Arrest and Apoptosis in Non-small Cell Lung Cancer Cells

doi:10.7314/APJCP.2014.15.16.6893

科研成果详情

题名	Curcumin Analogue A501 induces G2/M Arrest and Apoptosis in Non-small Cell Lung Cancer Cells
作者	Xia, Yi-Qun1,2; Wei, Xiao-Yan 1; Li, Wu-Lan1,3; Kanchana, Karvannan 1; Xu, Chao-Chao 1,2; Chen, Da-Hui 1; Chou, Pei-Hong 1; Jin, Rong2,4; Wu, Jian-Zhang 1; Liang, Guang 1
发表日期	2014-12-31
发表期刊	ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 影响因子和分区
语种	英语
原始文献类型	Article
关键词	NSCLC curcumin antitumor cycle arrest apoptosis
其他关键词	ENDOPLASMIC-RETICULUM STRESS ; MONO-CARBONYL ANALOGS ; TARGETED THERAPIES ; BIOLOGICAL EVALUATION ; ANTITUMOR-ACTIVITY ; IN-VIVO ; PROLIFERATION ; DESIGN ; ANGIOGENESIS ; ANTIOXIDANT
摘要	Curcumin and its analogues have been reported to exert anti-cancer activity against a variety of tumors. Here, we reported A501, a new curcumin analogue. The effect of A501 on cell viability was detected by MTT assay, the result showed that A501 had a better inhibiting effect on the four non-small cell lung cancer ( NSCLC) cells than that of curcumin. Moreover, Colony forming experiment showed A501 significant restrained cell proliferation. Flow cytometry displayed A501 can cause G2/M arrest and induce apoptosis. Western blotting showed that A501 decreased the expression of cyclinB1, cdc-2, bcl-2, while increased the expression of p53, cleaved caspase-3 and bax. In conclusion, curcumin analogues A501 played antitumor activity by inhibiting cell proliferation and inducing apoptosis of NSCLC cells. And it was likely to be a promising starting point for the development of curcumin-based anticancer drugs.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272462]; ZheJiang Province Natural Science Funding of China [LY12H30004]; Technology Foundation for Medical Science of Zhejiang Province [2012KYA129]
出版者	ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
出版地	GYEONGGI-DO
ISSN	1513-7368
卷号	15 期号:16 页码:6893-6898
DOI	10.7314/APJCP.2014.15.16.6893
页数	6
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000343832900071
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	25169542
SCOPUSEID	2-s2.0-84919773829
通讯作者地址	[Jin, Rong]Department of Digestive Diseases,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China
Scopus学科分类	Epidemiology;Oncology;Public Health, Environmental and Occupational Health;Cancer Research
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19404
专题	药学院（分析测试中心）附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_计算机与信息管理系
通讯作者	Jin, Rong
作者单位	1.Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou, Zhejiang,China; 2.Department of Digestive Diseases,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China; 3.College of Information Science and Computer Engineering,Wenzhou Medical University,Wenzhou, Zhejiang,China; 4.Department of Epidemiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Xia, Yi-Qun,Wei, Xiao-Yan,Li, Wu-Lan,et al. Curcumin Analogue A501 induces G2/M Arrest and Apoptosis in Non-small Cell Lung Cancer Cells[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(16):6893-6898.
APA	Xia, Yi-Qun., Wei, Xiao-Yan., Li, Wu-Lan., Kanchana, Karvannan., Xu, Chao-Chao., ... & Liang, Guang. (2014). Curcumin Analogue A501 induces G2/M Arrest and Apoptosis in Non-small Cell Lung Cancer Cells. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 15(16), 6893-6898.
MLA	Xia, Yi-Qun,et al."Curcumin Analogue A501 induces G2/M Arrest and Apoptosis in Non-small Cell Lung Cancer Cells".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.16(2014):6893-6898.