Analysis of risk factors for antiepileptic drug-induced adverse psychotropic effects in Chinese outpatients with epilepsy

doi:10.1016/j.jocn.2019.02.011

科研成果详情

题名	Analysis of risk factors for antiepileptic drug-induced adverse psychotropic effects in Chinese outpatients with epilepsy
作者	Du, Yan-ru 1; Lin, Jia-he 1; Mei, Pei-na 1; Wang, Li1; Wang, Yi2; Shen, Jing-zan 1; Ding, Si-qi 1; Ye, Meng-qian 1; Wang, Xin-shi1; Xia, Nian-ge1; Zheng, Rong-yuan1; Chen, Hong 3; Hou, Sheng-tao 1; Xu, Hui-qin1
发表日期	2019-05
发表期刊	JOURNAL OF CLINICAL NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Epilepsy Antiepileptic drugs Adverse psychotropic effects Risk factors
其他关键词	TOPIRAMATE ; MECHANISMS
摘要	Antiepileptic drugs (AEDs) have adverse psychotropic effects (APES). To explore the risk factors for AED-induced APES, we compared Chinese outpatients with epilepsy with and without AED-induced APEs. We reviewed the medical data of outpatients with epilepsy enrolled in the Epilepsy Long-term Follow Up Registry Study (ELFURS) between January 1, 2003 and December 31, 2015. Data on demographics, comorbidities, variables related to epilepsy, AED use, and APEs were collected. APEs were determined by experienced epileptologists based on the definition of adverse drug reaction (ADR) proposed by the World Health Organization (WHO) in 1972, and the causality relationship between APEs and suspected medications was assessed based on the WHO-UMC scale. APEs included effects on memory, sleep, behavior, mood, psychotic symptoms, and others in this study. We divided the study population into patients with and without AED-induced APEs and then compared the differences between the two groups using univariate and multivariate methods. A total of 3074 eligible patients were included in this study (1001 patients with AED-induced APEs and 2073 patients without AED-induced APES). Of all APEs, the effects on memory and sleep were most pronounced. The results show that the female sex (odds ratio [OR] 1.242, 95% confidence interval [CI] 1.055-1.463), psychotic disorder comorbidities (OR 1.815, 95% CI 1.159-2.841), polytherapy with AEDs (OR 1.400, 95% CI 1.061-1.847), and the duration of epilepsy (OR 1.010, 95% CI 1.000-1.020) are significant non drug risk factors for AED-induced APEs. Recognizing risk factors for APEs may help determine optimal treatment strategies for epilepsy. (C) 2019 Elsevier Ltd. All rights reserved.
资助项目	National Center for ADR Monitoring, China [2016(30)]; Natural Science Foundation of Zhejiang Province, ChinaNatural Science Foundation of Zhejiang Province [LY15H090015]
出版者	ELSEVIER SCI LTD
出版地	OXFORD
ISSN	0967-5868
EISSN	1532-2653
卷号	63 页码:37-42
DOI	10.1016/j.jocn.2019.02.011
页数	6
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000466249000008
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30827884
SCOPUSEID	2-s2.0-85062145071
通讯作者地址	[Xu, Hui-qin]Department of Neurology,First Affiliated Hospital of Wenzhou Medical University,Shangcai Village, Ouhai District,Wenzhou,China
Scopus学科分类	Surgery;Neurology;Neurology (clinical);Physiology (medical)
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19155
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院公共卫生学院_预防医学系精神医学学院_精神医学系
通讯作者	Xu, Hui-qin
作者单位	1.Department of Neurology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Wenzhou,China; 3.Department of Psychiatry,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Du, Yan-ru,Lin, Jia-he,Mei, Pei-na,et al. Analysis of risk factors for antiepileptic drug-induced adverse psychotropic effects in Chinese outpatients with epilepsy[J]. JOURNAL OF CLINICAL NEUROSCIENCE,2019,63:37-42.
APA	Du, Yan-ru., Lin, Jia-he., Mei, Pei-na., Wang, Li., Wang, Yi., ... & Xu, Hui-qin. (2019). Analysis of risk factors for antiepileptic drug-induced adverse psychotropic effects in Chinese outpatients with epilepsy. JOURNAL OF CLINICAL NEUROSCIENCE, 63, 37-42.
MLA	Du, Yan-ru,et al."Analysis of risk factors for antiepileptic drug-induced adverse psychotropic effects in Chinese outpatients with epilepsy".JOURNAL OF CLINICAL NEUROSCIENCE 63(2019):37-42.