Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlle d trial

doi:10.1016/j.imr.2021.100782

科研成果详情

题名	Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlle d trial
作者	Zeng, Congcong 1; Yuan, Zhengzhong1; Zhu, Jiahui2; Wang, Yintong2; Xie, Yongyong1; Ye, Ren1; Cheng, Jinguo1
发表日期	2021
发表期刊	INTEGRATIVE MEDICINE RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	COVID-19 Maxingshigan-Weijing decoction Symptom recovery Traditional Chinese medicine
摘要	Background: Wenzhou has achieved great progress in the prevention and control of the growing coronavirus disease 2019 (COVID-19) pandemic, and traditional Chinese medicine (TCM) has played an indispensable role in this fight. This study aimed to investigate the efficacy of Maxingshigan-Weijing decoction (MWD) in treating infected patients. Methods: This study was an open-label randomized controlled trial. Inpatients with mild or moderate symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were randomly treated with routine supportive care alone or a combination of routine supportive care and MWD. The primary outcome was the rate of symptom (fever, fatigue, cough and difficulty breathing) recovery. Results: Fifty-nine inpatients were enrolled, of whom 29 received routine supportive care alone (control group) and 30 received combination therapy (treatment group). The rate of symptom recovery was significantly higher in the treatment group than in the control group. The time to recovery of fever (3 vs. 7 days), fatigue (9 vs. 12 days), coughing (9 vs. 14 days) and difficulty breathing (4.5 vs. 9.5 days) was also significantly shorter in the treatment group (all p < 0.001). The syndrome score was lower after MWD treatment. However, neither group differed in the viral assay findings, hospitalization days, medication time or the rate of conversion to severe cases. Conclusions: MWD increased the rate of symptom recovery and shortened the time to recovery of clinical symptoms without deterioration to death or critical care. These findings may provide opportunities for the use of complementary medicine in treating this infection. (C) 2021 Korea Institute of Oriental Medicine. Published by Elsevier B.V.
资助项目	Wenzhou Municipal Science and Technology Bureau (CN) [ZY202003]
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	2213-4220
EISSN	2213-4239
卷号	10 期号:Suppl 页码:100782
DOI	10.1016/j.imr.2021.100782
页数	7
WOS类目	Integrative & Complementary Medicine
WOS研究方向	Integrative & Complementary Medicine
WOS记录号	WOS:000731606500006
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34660195
PMC记录号	PMC8507566
SCOPUSEID	2-s2.0-85117587727
通讯作者地址	[Cheng, Jinguo]Department of Traditional Chinese Medicine,The First Affiliated Hospital of Wenzhou Medical University,Nanbaixiang, Ouhai District,Wenzhou,China
Scopus学科分类	Complementary and Alternative Medicine
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19088
专题	附属第一医院_中医科第二临床医学院、附属第二医院、育英儿童医院_中医系
通讯作者	Cheng, Jinguo
作者单位	1.Department of Traditional Chinese Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.School of Traditional Chinese Medicine,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zeng, Congcong,Yuan, Zhengzhong,Zhu, Jiahui,et al. Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlle d trial[J]. INTEGRATIVE MEDICINE RESEARCH,2021,10(Suppl):100782.
APA	Zeng, Congcong., Yuan, Zhengzhong., Zhu, Jiahui., Wang, Yintong., Xie, Yongyong., ... & Cheng, Jinguo. (2021). Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlle d trial. INTEGRATIVE MEDICINE RESEARCH, 10(Suppl), 100782.
MLA	Zeng, Congcong,et al."Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlle d trial".INTEGRATIVE MEDICINE RESEARCH 10.Suppl(2021):100782.