Association of serum copper, zinc and selenium levels with risk of metabolic syndrome: A nested case-control study of middle-aged and older Chinese adults

doi:10.1016/j.jtemb.2018.12.017

科研成果详情

题名	Association of serum copper, zinc and selenium levels with risk of metabolic syndrome: A nested case-control study of middle-aged and older Chinese adults
作者	Fang, Chenchen1; Wu, Wenjun2; Gu, Xuejiang2; Dai, Shanshan 1; Zhou, Qi2; Deng, Huihui2; Shen, Feixia2; Chen, Junjie3
发表日期	2019
发表期刊	JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Copper Zinc Selenium Metabolic syndrome Component
其他关键词	IMPAIRED FASTING GLUCOSE ; OXIDATIVE STRESS ; ANTIOXIDANT SUPPLEMENTATION ; DIABETIC INDIVIDUALS ; INSULIN-RESISTANCE ; PLASMA SELENIUM ; TRACE-ELEMENTS ; LIPID PROFILE ; VITAMIN-E ; CANCERS
摘要	Trace elements, such as copper, zinc and selenium, have been linked to the development of metabolic syndrome. However, previous studies concerning these trace elements in association with metabolic syndrome have presented conflicting results in different countries. The aim of this study was to analyse the association between serum copper, zinc and selenium concentrations and the risk of metabolic syndrome among middle-aged and older Chinese adults. We performed a nested case-control study that included 349 individuals who developed metabolic syndrome (125 males and 224 females) during a 3-year follow-up and 349 controls matched by baseline age (+/-1 years), sex and area. Serum trace element concentrations were measured using atomic absorption spectrometry. The median serum selenium levels in males and females in the metabolic syndrome group were 82.2 (13.4) pg/L and 82.6 (11.1) pg/L, respectively, which were significantly higher than the serum selenium levels in the control group (p = 0.001 and p < 0.001). After adjusting for potential confounders, the odds ratios of risk for metabolic syndrome in the highest tertile of serum selenium levels were 2.72 [95% confidence interval (CI) 1.43-5.20; p for trend 0.002] for males and 5.30 (95% CI 3.31-8.74; p for trend < 0.001) for females, respectively, compared with the lowest tertile. In addition, serum selenium levels were positively correlated with postprandial plasma glucose in both genders (for males: odds ratio 2.42; 95% CI 1.27-4.61; for females: odds ratio 2.11; 95% CI 1.32-3.37) and negatively associated with high-density lipoprotein in only females (odds ratio 3.21; 95% CI 1.75-5.91). These results suggest that higher levels of serum selenium might be an independent risk factor for metabolic syndrome, especially in relation to elevated postprandial plasma glucose and reduced high-density lipoprotein levels. However, we failed to demonstrate an association between copper or zinc status and metabolic syndrome or its components.
资助项目	Chinese Society of Endocrinology; National Clinical Research Centre for Metabolic Diseases and Science and Technology Program project funds of Wenzhou [Y20170286]
出版者	ELSEVIER GMBH
出版地	MUNICH
ISSN	0946-672X
EISSN	1878-3252
卷号	52 页码:209-215
DOI	10.1016/j.jtemb.2018.12.017
页数	7
WOS类目	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS记录号	WOS:000463958300028
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30732884
SCOPUSEID	2-s2.0-85059558666
通讯作者地址	[Shen, Feixia]Department of Endocrine and Metabolic Diseases,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Biochemistry;Molecular Medicine;Inorganic Chemistry
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18991
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_内科学_呼吸与危重症医学科
通讯作者	Shen, Feixia
作者单位	1.Department of Emergency,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Endocrine and Metabolic Diseases,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Fang, Chenchen,Wu, Wenjun,Gu, Xuejiang,et al. Association of serum copper, zinc and selenium levels with risk of metabolic syndrome: A nested case-control study of middle-aged and older Chinese adults[J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,2019,52:209-215.
APA	Fang, Chenchen., Wu, Wenjun., Gu, Xuejiang., Dai, Shanshan., Zhou, Qi., ... & Chen, Junjie. (2019). Association of serum copper, zinc and selenium levels with risk of metabolic syndrome: A nested case-control study of middle-aged and older Chinese adults. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 52, 209-215.
MLA	Fang, Chenchen,et al."Association of serum copper, zinc and selenium levels with risk of metabolic syndrome: A nested case-control study of middle-aged and older Chinese adults".JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 52(2019):209-215.