cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/beta-Catenin Pathway

doi:10.1371/journal.pone.0131225

科研成果详情

题名	cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/beta-Catenin Pathway
作者	Huang, Guanli1; Zhu, Hua 2,3; Shi, Yixiong4; Wu, Wenzhi4; Cai, Huajie 5; Chen, Xiangjian5
发表期刊	PLOS ONE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	SQUAMOUS-CELL CARCINOMA ; UBIQUITIN LIGASE ITCH ; CIRCULAR RNAS ; CHINESE POPULATIONS ; IDENTIFICATION ; TUMORIGENESIS ; POLYMORPHISM ; DEGRADATION ; SPONGES ; GROWTH
摘要	Noncoding RNAs (ncRNAs) are the dominant product of eukaryotic transcription. These products range from short microRNAs (miRNAs) to long intergenic noncoding RNAs (lincRNAs). Circular RNAs composed of exonic sequences represent an understudied form of ncRNA that was discovered more than 20 years ago. Using a TaqMan-based reverse transcriptase polymerase chain reaction assay, we analyzed the relationship between cir-ITCH expression and colorectal cancer (CRC) in a total of 45 CRCs and paired adjacent nontumor tissue samples. We found that cir-ITCH expression was typically down-regulated in CRC compared to the peritumoral tissue. This result, as well as several follow-up experiments, showed that cir-ITCH could increase the level of ITCH, which is involved in the inhibition of the Wnt/beta-catenin pathway. Therefore, our results showed that cir-ITCH plays a role in CRC by regulating the Wnt/beta-catenin pathway.
资助项目	Wenzhou Science and Technology Bureau Natural Science Foundation [Y20140700]
出版者	PUBLIC LIBRARY SCIENCE
出版地	SAN FRANCISCO
ISSN	1932-6203
卷号	10 期号:6 页码:e0131225.
DOI	10.1371/journal.pone.0131225
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000356933800132
收录类别	SCIE ; PUBMED
发表日期	2015-06-25
URL	查看原文
Pubmed记录号	26110611
PMC记录号	PMC4482251
引用统计	被引频次：232[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18765
专题	附属第一医院
通讯作者	Chen, Xiangjian
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Surg Oncol, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Obstet, Wenzhou, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Wenzhou, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Endoscop Surg, Wenzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Huang, Guanli,Zhu, Hua,Shi, Yixiong,et al. cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/beta-Catenin Pathway[J]. PLOS ONE,2015,10(6):e0131225..
APA	Huang, Guanli, Zhu, Hua, Shi, Yixiong, Wu, Wenzhi, Cai, Huajie, & Chen, Xiangjian. (2015). cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/beta-Catenin Pathway. PLOS ONE, 10(6), e0131225..
MLA	Huang, Guanli,et al."cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/beta-Catenin Pathway".PLOS ONE 10.6(2015):e0131225..