Arterial oxygen pressure targets in critically ill patients: Analysis of a large ICU database

doi:10.1016/j.hrtlng.2020.10.015

科研成果详情

题名	Arterial oxygen pressure targets in critically ill patients: Analysis of a large ICU database
作者	Xu, Chang 1; Jiang, Dan-wei 1; Qiu, Wei-yong2; Zhou, Yan-xue 3; Chen, Long-wang 1; Hong, Guang-liang1; Zhao, Guang-ju1; Lu, Zhong-qiu1
发表日期	2021-02
发表期刊	HEART & LUNG 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Arterial oxygenation Optimal range Oxygen therapy Intensive care units Hospital mortality
其他关键词	POTENTIAL ERRORS ; PULSE OXIMETRY ; VENTILATED PATIENTS ; HYPEROXIA ; MULTICENTER ; ASSOCIATION ; MORTALITY ; THERAPY
摘要	Background: Providing supplemental oxygen is common in the management of critically ill patients, yet the optimal oxygen regimen remains unclear. Objectives: To explore the optimal range of PaO2 in critically ill patients. Methods: This is a retrospective study conducted in the Medical Information Mart for Intensive Care III (MIMIC-III) database. The patients with a least 48 h of oxygen therapy were included. Nonlinear regression was used to analyze the association between PaO2 and mortality. We derived an optimal range of PaO2 and evaluated the association between the proportion of PaO2 measurements within this range and mortality. Results: In total, 8401 patients were included in the study. A J-shaped relationship was observed between median PaO2 and hospital mortality. Compared with the reference group of 100-120 mmHg, patients with values of 80-100 mmHg and 120-140 mmHg had higher hospital mortality (adjusted odds ratio [aORI, 1.23; 95%Cl, 1.05-1.43 and 1.29; 95%CI, 1.08-1.54, respectively). Similarly, mortality rates were significantly higher for PaO2 <80 mmHg and >= 140 mmHg (aOR, 1.97; 95%CI, 1.58-2.45 and 1.42; 95%CI, 1.19-1.69, respectively). Patients spent a greater proportion of time within 100-120 mmHg tended to have a lower mortality rate. Conclusion: Among critically ill patients, the relationship between median PaO2 and hospital mortality was J-shaped. The lowest rates of mortality was observed in those with PaO2 levels within 100 to 120 mmHg. (C) 2020 Elsevier Inc. All rights reserved.
出版者	MOSBY-ELSEVIER
出版地	NEW YORK
ISSN	0147-9563
EISSN	1527-3288
卷号	50 期号:1 页码:220-225
DOI	10.1016/j.hrtlng.2020.10.015
页数	6
WOS类目	Cardiac & Cardiovascular Systems ; Nursing ; Respiratory System
WOS研究方向	Cardiovascular System & Cardiology ; Nursing ; Respiratory System
WOS记录号	WOS:000600693100037
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33143913
SCOPUSEID	2-s2.0-85094971379
通讯作者地址	[Zhao, Guang-ju]Emergency Intensive Care Unit,Emergency Department,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Pulmonary and Respiratory Medicine;Critical Care and Intensive Care Medicine;Cardiology and Cardiovascular Medicine
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18673
专题	附属第一医院其他_附属义乌医院（义乌市中心医院）
通讯作者	Zhao, Guang-ju
作者单位	1.Emergency Intensive Care Unit,Emergency Department,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Intensive Care Unit,Yiwu Hospital Affiliated to Wenzhou Medical University,Yiwu,322000,China; 3.Department of Nephrology,Yiwu Hospital Affiliated to Wenzhou Medical University,Yiwu,322000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xu, Chang,Jiang, Dan-wei,Qiu, Wei-yong,et al. Arterial oxygen pressure targets in critically ill patients: Analysis of a large ICU database[J]. HEART & LUNG,2021,50(1):220-225.
APA	Xu, Chang., Jiang, Dan-wei., Qiu, Wei-yong., Zhou, Yan-xue., Chen, Long-wang., ... & Lu, Zhong-qiu. (2021). Arterial oxygen pressure targets in critically ill patients: Analysis of a large ICU database. HEART & LUNG, 50(1), 220-225.
MLA	Xu, Chang,et al."Arterial oxygen pressure targets in critically ill patients: Analysis of a large ICU database".HEART & LUNG 50.1(2021):220-225.