Development of LC-MS determination method and back-propagation ANN pharmacokinetic model of corynoxeine in rat

doi:10.1016/j.jchromb.2014.03.024

科研成果详情

题名	Development of LC-MS determination method and back-propagation ANN pharmacokinetic model of corynoxeine in rat
作者	Ma, Jianshe1; Cai, Jinzhang2; Lin, Guanyang3; Chen, Huilin 4; Wang, Xianqin1; Wang, Xianchuan1; Hu, Lufeng3
发表日期	2014-05-15
发表期刊	JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Corynoxeine LC-MS Pharmacokinetics BP-ANN
其他关键词	ARTIFICIAL NEURAL-NETWORK ; UNCARIA-RHYNCHOPHYLLA ; CELL PROLIFERATION ; INDOLE ALKALOIDS ; HOOK ; ISORHYNCHOPHYLLINE ; PREDICTION ; RISK
摘要	Corynoxeine(CX), isolated from the extract of Uncaria rhynchophylla, is a useful and prospective compound in the prevention and treatment for vascular diseases. A simple and selective liquid chromatography mass spectrometry (LC-MS) method was developed to determine the concentration of CX in rat plasma. The chromatographic separation was achieved on a Zorbax SB-C-18 (2.1 mm x 150 mm, 5 mu m) column with acetonitrile-0.1% formic acid in water as mobile phase. Selective ion monitoring (SIM) mode was used for quantification using target ions m/z 383 for CX and m/z 237 for the carbamazepine (IS). After the LC-MS method was validated, it was applied to a back-propagation artificial neural network (BP-ANN) pharmacokinetic model study of CX in rats. The results showed that after intravenous administration of CX, it was mainly distributed in blood and eliminated quickly, t(1/2) was less than 1 h. The predicted concentrations generated by BP-ANN model had a high correlation coefficient (R > 0.99) with experimental values. The developed BP-ANN pharmacokinetic model can be used to predict the concentration of CX in rats (c) 2014 Elsevier B.V. All rights reserved.
资助项目	Key Academic Subject (Clinical Chinese Pharmacy) of the Twelfth-Five Year Program of State Administration of Traditional Chinese Medicine; Key Construction Academic Subject (Medical Innovation) of Zhejiang Province [11-CX26]; National Natural Science Foundation of Youth [61303113]
出版者	ELSEVIER SCIENCE BV
出版地	AMSTERDAM
ISSN	1570-0232
EISSN	1873-376X
卷号	959 页码:10-15
DOI	10.1016/j.jchromb.2014.03.024
页数	6
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS记录号	WOS:000336471500003
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20141717616224
EI主题词	Backpropagation
URL	查看原文
PubMed ID	24732215
SCOPUSEID	2-s2.0-84905033853
通讯作者地址	[Hu, Lufeng]Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University,China
Scopus学科分类	Analytical Chemistry;Biochemistry;Clinical Biochemistry;Cell Biology
引用统计	被引频次：60[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1864
专题	基础医学院（机能实验教学中心）_基础医学实验教学中心_机能实验教学中心（挂靠、校级）附属第一医院第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Hu, Lufeng
作者单位	1.Function Experiment Teaching Center, Wenzhou Medical University,China; 2.The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,China; 3.The First Affiliated Hospital of Wenzhou Medical University,China; 4.College of Physics and Electronic Information Engineering, Wenzhou University,China
第一作者单位	基础医学院（机能实验教学中心）_基础医学实验教学中心_机能实验教学中心（挂靠、校级）
通讯作者单位	附属第一医院
第一作者的第一单位	基础医学院（机能实验教学中心）_基础医学实验教学中心_机能实验教学中心（挂靠、校级）
推荐引用方式 GB/T 7714	Ma, Jianshe,Cai, Jinzhang,Lin, Guanyang,et al. Development of LC-MS determination method and back-propagation ANN pharmacokinetic model of corynoxeine in rat[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2014,959:10-15.
APA	Ma, Jianshe., Cai, Jinzhang., Lin, Guanyang., Chen, Huilin., Wang, Xianqin., ... & Hu, Lufeng. (2014). Development of LC-MS determination method and back-propagation ANN pharmacokinetic model of corynoxeine in rat. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 959, 10-15.
MLA	Ma, Jianshe,et al."Development of LC-MS determination method and back-propagation ANN pharmacokinetic model of corynoxeine in rat".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 959(2014):10-15.