A novel FGF2 antagonist peptide P8 with potent antiproliferation activity

doi:10.1007/s13277-014-2356-4

科研成果详情

题名	A novel FGF2 antagonist peptide P8 with potent antiproliferation activity
作者	Fan, Lei 1; Xie, Hang 1; Chen, Lingzi 1; Ye, Hui1,2; Ying, Shilong 1; Wang, Cong1; Wu, Xiaoping1,3; Li, Wulan1,4; Wu, Jianzhang1; Liang, Guang1; Li, Xiaokun1
发表日期	2014-10
发表期刊	TUMOR BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	FGF2-binding peptide Cell proliferation Cell cycle Signaling pathway Multi-targets
其他关键词	FIBROBLAST-GROWTH-FACTOR ; CELL-PROLIFERATION ; BINDING PEPTIDE ; CANCER CELLS ; IDENTIFICATION ; INHIBITORS ; MELANOMA ; ANGIOGENESIS ; AUTOCRINE ; RECEPTORS
摘要	Some fibroblast growth factors (FGFs) play a critical role in tumorigenesis and progression. Among them, FGF2 was highly expressed in some tumors, and antagonists binding to FGF2 can suppress the growth of tumor cells. Therefore, FGF2 has been considered as an important target in cancer therapy. In this study, we identified a novel FGF2-binding short peptide (P8, PLLQATAGGGS-NH2) using phage display technology and alanine scanning. The P8 peptide suppressed FGF2-induced proliferation with no cytotoxic effect on cells, arrested the cycle at the G0/G1 phase in B16-F10 cells, and downregulated the activation of fibroblast growth factor receptor substrate 2 alpha (FRS2 alpha)/ERK cascade in B16-F10, NIH-H460, and SGC-7901 cells. Besides, P8 peptide can also inhibit the phosphorylation of FRS2 alpha stimulated by FGF1 and KGF2. These implied that P8 peptide may develop as a multi-target antagonist peptide contributing to tumor treatment.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81102310, 81272462, 81101712]; Natural Science Foundation of Zhejiang Province of ChinaNatural Science Foundation of Zhejiang Province [Y4110029]; Technology Foundation for Medical Science of Zhejiang Province [2012KYA127]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Guangdong Provincial Thousand-Hundred-Ten Talent Project; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Jinan University; National Undergraduate Training Programs for Innovation and Entrepreneurship [201310343001]
出版者	SPRINGER
出版地	DORDRECHT
ISSN	1010-4283
EISSN	1423-0380
卷号	35 期号:10 页码:10571-10579
DOI	10.1007/s13277-014-2356-4
页数	9
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000344532700130
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	25062723
SCOPUSEID	2-s2.0-84922394689
通讯作者地址	[Li, Wulan]Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Cancer Research
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18614
专题	药学院（分析测试中心）_药学系温州医科大学基础医学院（机能实验教学中心）
通讯作者	Li, Wulan
作者单位	1.Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 3.Institute of Tissue Transplantation and Immunology,Jinan University,Guangzhou,510632,China; 4.College of Information Science and Computer Engineering,Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	药学院（分析测试中心）_药学系
通讯作者单位	药学院（分析测试中心）_生物有机与药物化学研究中心
第一作者的第一单位	药学院（分析测试中心）_药学系
推荐引用方式 GB/T 7714	Fan, Lei,Xie, Hang,Chen, Lingzi,et al. A novel FGF2 antagonist peptide P8 with potent antiproliferation activity[J]. TUMOR BIOLOGY,2014,35(10):10571-10579.
APA	Fan, Lei., Xie, Hang., Chen, Lingzi., Ye, Hui., Ying, Shilong., ... & Li, Xiaokun. (2014). A novel FGF2 antagonist peptide P8 with potent antiproliferation activity. TUMOR BIOLOGY, 35(10), 10571-10579.
MLA	Fan, Lei,et al."A novel FGF2 antagonist peptide P8 with potent antiproliferation activity".TUMOR BIOLOGY 35.10(2014):10571-10579.