Therapeutic antibodies for spinal cord injury

doi:10.2174/1871527315666160915150754

科研成果详情

题名	Therapeutic antibodies for spinal cord injury
作者	Tang, Dan-Yang 1; Zhao, Wei-Jiang 2
发表日期	2017-02-01
发表期刊	CNS and Neurological Disorders - Drug Targets; 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Anti-immune reaction Antibody Myelin repair Neuropathic pain Neuroprotective Spinal cord injury
摘要	Spinal cord injury (SCI) is a long-lasting damage in the spinal cord that leads to paraparesis, paraplegia, quadriplegia and other lifetime disabilities. The underlying mechanisms responsible for the failure of axonal regeneration after SCI remain only partially understood. Although a spectrum of medical treatments has been made available for this disease, the therapeutic effects remain disappointing. The emergence of antibody treatment has paved a new pathway for the management of SCI. In this current review, we summarized the application of antibodies in SCI in studies of myelin repair, neuroprotection, axon outgrowth, and anti-immune reaction. In the meantime, the combination treatment of the antibody with other reagents or stem cell transplant was also reviewed.
资助项目	National Natural Science Foundation of China[81171138,81471279];Shantou University Medical College[2501220118];
出版者	Bentham Science Publishers B.V.P.O. Box 294Bussum1400 AG
ISSN	1871-5273
EISSN	1996-3181
卷号	16 期号:1 页码:51-64
DOI	10.2174/1871527315666160915150754
收录类别	SCOPUS
URL	查看原文
PubMed ID	27633782
SCOPUSEID	2-s2.0-85011044823
通讯作者地址	[Zhao, Wei-Jiang]Department of Neurology,First Affiliated Hospital of Nanjing Medical University,P.O. Box: No. 300, Guangzhou Road,Nanjing,210029,China
Scopus学科分类	Neuroscience (all);Pharmacology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/185616
专题	温州医科大学
通讯作者	Zhao, Wei-Jiang
作者单位	1.Department of Rehabilitation,Wenzhou Chinese Medicine Hospital,27 Xin He Rd, Lucheng District,Wenzhou,325000,China; 2.Center for Neuroscience,Shantou University Medical College,22 Xin Ling Rd, Jinping District,Shantou,515041,China
推荐引用方式 GB/T 7714	Tang, Dan-Yang,Zhao, Wei-Jiang. Therapeutic antibodies for spinal cord injury[J]. CNS and Neurological Disorders - Drug Targets;,2017,16(1):51-64.
APA	Tang, Dan-Yang, & Zhao, Wei-Jiang. (2017). Therapeutic antibodies for spinal cord injury. CNS and Neurological Disorders - Drug Targets;, 16(1), 51-64.
MLA	Tang, Dan-Yang,et al."Therapeutic antibodies for spinal cord injury".CNS and Neurological Disorders - Drug Targets; 16.1(2017):51-64.