Causal relationships between type 2 diabetes, glycemic traits and keratoconus

doi:10.3389/fmed.2023.1264061

科研成果详情

题名	Causal relationships between type 2 diabetes, glycemic traits and keratoconus
作者	Zhu, Xueying; Cheng, Dan; Ruan, Kaiming; Shen, Meixiao; Ye, Yufeng
发表日期	2023
发表期刊	Frontiers in Medicine; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	fasting glucose genome-wide association study keratoconus Mendelian randomization proinsulin levels type 2 diabetes
其他关键词	MENDELIAN RANDOMIZATION ; LYSYL OXIDASE ; ASSOCIATION ; PROINSULIN ; EXPRESSION ; COLLAGEN
摘要	Purpose: The relationship between diabetes mellitus and keratoconus remains controversial. This study aimed to assess the potential causal relationships among type 2 diabetes, glycemic traits, and the risk of keratoconus. Methods: We used a two-sample Mendelian randomization (MR) design based on genome-wide association summary statistics. Fasting glucose, proinsulin levels, adiponectin, hemoglobin A1c (HbA1c) and type 2 diabetes with and without body mass index (BMI) adjustment were used as exposures and keratoconus was used as the outcome. MR analysis was performed using the inverse-variance weighted method, MR-Egger regression method, weighted-mode method, weighted median method and the MR-pleiotropy residual sum and outlier test (PRESSO). Results: Results showed that genetically predicted lower fasting glucose were significantly associated with a higher risk of keratoconus [IVW: odds ratio (OR) = 0.382; 95% confidence interval (CI) = 0.261–0.560; p = 8.162 × 10−7]. Genetically predicted lower proinsulin levels were potentially linked to a higher risk of keratoconus (IVW: OR = 0.739; 95% CI = 0.568–0.963; p = 0.025). In addition, genetically predicted type 2 diabetes negatively correlated with keratoconus (IVW: BMI-unadjusted: OR = 0.869; 95% CI = 0.775–0.974, p = 0.016; BMI-adjusted: OR = 0.880, 95% CI = 0.789–0.982, p = 0.022). These associations were further corroborated by the evidence from all sensitivity analyses. Conclusion: These findings provide genetic evidence that higher fasting glucose levels are associated with a lower risk of keratoconus. However, further studies are required to confirmed this hypothesis and to understand the mechanisms underlying this putative causative relationship.
资助项目	Science and Technology Innovation Activity Plan of Zhejiang[2023R413086];National Natural Science Foundation of China[81900910];
出版者	FRONTIERS MEDIA SA
ISSN	2296-858X
EISSN	2296-858X
卷号	10
DOI	10.3389/fmed.2023.1264061
页数	9
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:001103868800001
收录类别	SCOPUS ; PUBMED ; SCIE
URL	查看原文
PubMed ID	38020157
SCOPUSEID	2-s2.0-85177197827
通讯作者地址	[Ye, Yufeng]National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184696
专题	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Ye, Yufeng
作者单位	National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou,China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Zhu, Xueying,Cheng, Dan,Ruan, Kaiming,et al. Causal relationships between type 2 diabetes, glycemic traits and keratoconus[J]. Frontiers in Medicine;,2023,10.
APA	Zhu, Xueying, Cheng, Dan, Ruan, Kaiming, Shen, Meixiao, & Ye, Yufeng. (2023). Causal relationships between type 2 diabetes, glycemic traits and keratoconus. Frontiers in Medicine;, 10.
MLA	Zhu, Xueying,et al."Causal relationships between type 2 diabetes, glycemic traits and keratoconus".Frontiers in Medicine; 10(2023).