Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study

doi:10.3389/fimmu.2023.1199896

科研成果详情

题名	Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study
作者	Xie, Weidong1; Jiang, Haojie1; Chen, Yao 2; Zhang, Huanhao 3; Song, Yaoyu 3; Yu, Zhaojie 3; Gu, Huayan4; Xu, Hongkai1; Han, Saiyi5; Li, Sen6; Liu, Naxin1; Han, Shaoliang1
发表日期	2023-11-03
发表期刊	FRONTIERS IN IMMUNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Mendelian randomization (MR) systemic lupus erythematosus (SLE) inflammatory bowel disease (IBD) ulcerative colitis (UC) Crohn's-disease (CD)
其他关键词	SUSCEPTIBILITY LOCI ; CROHNS-DISEASE ; EPIDEMIOLOGY
摘要	Background: Previous studies have shown a coexistence phenomenon between systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), but the causal relationship between them is still unclear. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis using publicly available summary statistics data to evaluate whether there was a causal relationship between the two diseases.Methods: Summary statistics for SLE and IBD were downloaded from the Open Genome-Wide Association Study and the International Inflammatory Bowel Disease Genetics Consortium. European and East Asian populations were included in this MR work. We adopted a series of methods to select instrumental variables that are closely related to SLE and IBD. To make the conclusion more reliable, we applied a variety of different analysis methods, among which the inverse variance-weighted (IVW) method was the main method. In addition, heterogeneity, pleiotropy, and sensitivity were assessed to make the conclusions more convincing.Results: In the European population, a negative causal relationship was observed between SLE and overall IBD (OR = 0.94; 95% CI = 0.90, 0.98; P < 0.004) and ulcerative colitis (UC) (OR = 0.93; 95% CI = 0.88, 0.98; P = 0.006). After removing outliers with Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO), the results remained consistent with IVW. However, there was no causal relationship between SLE and Crohn's disease. In the East Asian population, no causal relationship was found between SLE and IBD.Conclusion: Our results found that genetic susceptibility to SLE was associated with lower overall IBD risk and UC risk in European populations. In contrast, no association between SLE and IBD was found in East Asian populations. This work might enrich the previous research results, and it may provide some references for research in the future.
资助项目	This project was sponsored by the Zhejiang Medical and Health Project (Key Talents) (2014RCA014), Wenzhou Municipal Science and Bureau (Y20210184), Natural Science Foundation of Zhejiang Province (LQ20H020002), and the Zhejiang Provincial Health Department [2014RCA014]; Zhejiang Medical and Health Project (Key Talents) [Y20210184]; Wenzhou Municipal Science and Bureau [LQ20H020002]; Natural Science Foundation of Zhejiang Province [11-ZC24]; Zhejiang Provincial Health Department Medical Support Discipline-Nutrition
出版者	FRONTIERS MEDIA SA
ISSN	1664-3224
卷号	14
DOI	10.3389/fimmu.2023.1199896
页数	8
WOS类目	Immunology
WOS研究方向	Immunology
WOS记录号	WOS:001105820400001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38022503
SCOPUSEID	2-s2.0-85177210200
通讯作者地址	[Liu, Naxin]Department of The Gastrointestinal Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Han, Shaoliang]Department of The Gastrointestinal Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Immunology and Allergy;Immunology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184025
专题	附属第一医院温州医科大学基础医学院（机能实验教学中心）其他_温州医科大学附属衢州医院
通讯作者	Liu, Naxin; Han, Shaoliang
作者单位	1.Department of The Gastrointestinal Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Medical Oncology,Sir Run Run Shaw Hospital,School of Medicine,Graduate School,Zhejiang University,Hangzhou,China; 3.Wenzhou Medical University,Wenzhou,China; 4.Department of Breast Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 5.The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou people’s Hospital,Quzhou,China; 6.School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xie, Weidong,Jiang, Haojie,Chen, Yao,et al. Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study[J]. FRONTIERS IN IMMUNOLOGY,2023,14.
APA	Xie, Weidong., Jiang, Haojie., Chen, Yao., Zhang, Huanhao., Song, Yaoyu., ... & Han, Shaoliang. (2023). Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study. FRONTIERS IN IMMUNOLOGY, 14.
MLA	Xie, Weidong,et al."Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study".FRONTIERS IN IMMUNOLOGY 14(2023).