Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviors in a chronic unpredictable mild stress mouse model of depression

doi:10.1080/15622975.2023.2279958

科研成果详情

题名	Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviors in a chronic unpredictable mild stress mouse model of depression
作者	Qianfa Yuan 1; Yuying Lei2; Kai Yu2; Junnan Wu2; Zhizhong Xu 1; Chunyan Wen 1; Yanlong Liu2,3; Wenqiang Wang 1; Jue He2,3,4
发表日期	2023-11-21
发表期刊	The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	BDNF GFAP astroglia depression fluoxetine rTMS
其他关键词	PRENATAL STRESS ; ANIMAL-MODEL ; QUETIAPINE ; ANXIETY ; DEFICIT ; RATS
摘要	Repetitive transcranial magnetic stimulation (rTMS) has been considered as an effective antidepressant treatment; however, the mechanism of its antidepressant effect is still unclear. Fluoxetine, a selective serotonin reuptake inhibitor antidepressant, may be neuroprotective. The objective of the present study was to evaluate the effect and underlying possible neuroprotective mechanism of rTMS and fluoxetine on abnormal behaviors in a depressive mouse model induced by chronic unpredictable mild stress (CUMS). After 28 days of CUMS exposure, mice were chronically treated with rTMS (10 Hz for 5 seconds per train, total 20 trains per day) and (or) fluoxetine (5 mg/kg/day, intraperitoneally) for 28 days targeting on the frontal cortex. After the behavioral tests, the protein expressions of glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) were measured by immunohistochemistry and (or) Western Blot. The results showed rTMS and (or) fluoxetine attenuated the locomotion decrease, anxiety and depressive-like behaviors in the CUMS-exposed mice. Our results suggest that both rTMS and fluoxetine could benefit the CUMS-induced abnormal behaviors including depressive-like behaviors, and the beneficial effects of rTMS as well as fluoxetine on depression might be partly related to their neuroprotective effect on attenuating astroglial activation and BDNF decrease.
资助项目	Xiamen Medical and Health Guidance Project [3502Z20199092]; Fujian Provincial Health Youth Scientific Research Project [2019-2-54]; Fujian Provincial Health Commission [2017-CXB-17]; National Nature Science Foundation of China [81871058, 81671266]
出版者	TAYLOR & FRANCIS LTD
ISSN	1562-2975
EISSN	1814-1412
DOI	10.1080/15622975.2023.2279958
页数	13
WOS类目	Psychiatry
WOS研究方向	Psychiatry
WOS记录号	WOS:001108093600001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	37942712
SCOPUSEID	2-s2.0-85177176261
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183801
专题	精神医学学院其他_附属康宁医院（温州市康宁医院）
作者单位	1.Xiamen Xian Yue Hospital, Xian Yue Hospital Affiliated with Xiamen Medical College, Fujian Psychiatric Center, Fujian Clinical Research Center for Mental Disorders, Xiamen, Fujian, China.; 2.School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.; 3.The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.; 4.Institute of Neurological Disease, First Affiliated Hospital, Henan University, Kaifeng, Henan, China.
推荐引用方式 GB/T 7714	Qianfa Yuan,Yuying Lei,Kai Yu,et al. Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviors in a chronic unpredictable mild stress mouse model of depression[J]. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry,2023.
APA	Qianfa Yuan., Yuying Lei., Kai Yu., Junnan Wu., Zhizhong Xu., ... & Jue He. (2023). Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviors in a chronic unpredictable mild stress mouse model of depression. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
MLA	Qianfa Yuan,et al."Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviors in a chronic unpredictable mild stress mouse model of depression".The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2023).