Microbial-host-isozyme: unveiling a new era in microbiome-host interaction

doi:10.1080/19490976.2023.2267185

科研成果详情

名称	Microbial-host-isozyme: unveiling a new era in microbiome-host interaction
作者	Miao, Lei 1; Tilg, Herbert 2; Zheng, Ming-Hua3,4
发表期刊	GUT MICROBES
语种	英语
原始文献类型	Letter
关键词	Microbial-Host isozymes metabolic diseases
摘要	Wang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota-host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens new avenues for metabolic disorder treatment. However, the complex nature of gut symbiotic bacteria requires further research to understand MHI mechanisms, regulatory roles, and interactions with the host. Precise interventions in gut microbiota offer personalized approaches to metabolic diseases.
出版者	TAYLOR & FRANCIS INC
ISSN	1949-0976
EISSN	1949-0984
卷号	15
期号	2
DOI	10.1080/19490976.2023.2267185
页数	2
WOS类目	Gastroenterology & Hepatology ; Microbiology
WOS研究方向	Gastroenterology & Hepatology ; Microbiology
WOS记录号	WOS:001083483200001
收录类别	SCIE ; SCOPUS
发布日期	2023-12-18
URL	查看原文
PubMed ID	37815552
通讯作者地址	[Zheng, Ming-Hua]Wenzhou Med Univ, MAFLD Res Ctr, Dept Hepatol, Affiliated Hosp 1, Wenzhou, Peoples R China. ; [Zheng, Ming-Hua]Dept Lab, Key Lab Diag & Treatment Dev Chron Liver Dis Zheji, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类	Microbiology;Microbiology (medical);Gastroenterology;Infectious Diseases
SCOPUSEID	SCOPUS_ID:85173414987
TOP期刊	TOP期刊
引用统计
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183632
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院附属第一医院附属第二医院_消化内科
通讯作者	Zheng, Ming-Hua
作者单位	1.Wenzhou Med Univ, Dept Gastroenterol, Affiliated Hosp 2, Wenzhou, Zhejiang, Peoples R China; 2.Med Univ Innsbruck, Dept Internal Med Gastroenterol Hepatol Endocrinol, Innsbruck, Austria; 3.Wenzhou Med Univ, MAFLD Res Ctr, Dept Hepatol, Affiliated Hosp 1, Wenzhou, Peoples R China; 4.Dept Lab, Key Lab Diag & Treatment Dev Chron Liver Dis Zheji, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 消化内科
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Miao, Lei,Tilg, Herbert,Zheng, Ming-Hua. Microbial-host-isozyme: unveiling a new era in microbiome-host interaction. 2023.