Automated evaluation of retinal hyperreflective foci changes in diabetic macular edema patients before and after intravitreal injection

doi:10.3389/fmed.2023.1280714

科研成果详情

题名	Automated evaluation of retinal hyperreflective foci changes in diabetic macular edema patients before and after intravitreal injection
作者	Wang, Xingguo1,2; Zhang, Yanyan 3; Ma, Yuhui 2; Kwapong, William Robert 4; Ying, Jianing 5; Lu, Jiayi1,2; Ma, Shaodong 2; Yan, Qifeng 2; Yi, Quanyong 3; Zhao, Yitian 1,2
发表日期	2023-10-06
发表期刊	FRONTIERS IN MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	diabetic macular edema hyperreflective foci optical coherence tomography artificial intelligence deep learning
其他关键词	OPTICAL COHERENCE TOMOGRAPHY ; ASSOCIATION
摘要	Purpose: Fast and automated reconstruction of retinal hyperreflective foci (HRF) is of great importance for many eye-related disease understanding. In this paper, we introduced a new automated framework, driven by recent advances in deep learning to automatically extract 12 three-dimensional parameters from the segmented hyperreflective foci in optical coherence tomography (OCT).Methods: Unlike traditional convolutional neural networks, which struggle with long-range feature correlations, we introduce a spatial and channel attention module within the bottleneck layer, integrated into the nnU-Net architecture. Spatial Attention Block aggregates features across spatial locations to capture related features, while Channel Attention Block heightens channel feature contrasts. The proposed model was trained and tested on 162 retinal OCT volumes of patients with diabetic macular edema (DME), yielding robust segmentation outcomes. We further investigate HRF's potential as a biomarker of DME.Results: Results unveil notable discrepancies in the amount and volume of HRF subtypes. In the whole retinal layer (WR), the mean distance from HRF to the retinal pigmented epithelium was significantly reduced after treatment. In WR, the improvement in central macular thickness resulting from intravitreal injection treatment was positively correlated with the mean distance from HRF subtypes to the fovea.Conclusion: Our study demonstrates the applicability of OCT for automated quantification of retinal HRF in DME patients, offering an objective, quantitative approach for clinical and research applications.
资助项目	The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported in part by the National Natural Science Foundation of China (62272444); Zhejiang Provincial Natural Science Found [62272444]; National Natural Science Foundation of China [LR22F020008]; Zhejiang Provincial Natural Science Foundation [2021298]; Youth Innovation Promotion Association CAS [62302488]; National Science Foundation Program of China [LQ23F010007]; Zhejiang Provincial Natural Science Foundation of China
出版者	FRONTIERS MEDIA SA
ISSN	2296-858X
EISSN	2296-858X
卷号	10
DOI	10.3389/fmed.2023.1280714
页数	13
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:001085969900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37869163
SCOPUSEID	2-s2.0-85174802429
通讯作者地址	[Zhao, Yitian]Cixi Biomedical Research Institute,Wenzhou Medical University,Ningbo,China ; [Yi, Quanyong]The Affiliated Ningbo Eye Hospital of Wenzhou Medical University,Ningbo,China
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183530
专题	温州医科大学其他_附属宁波市眼科医院
通讯作者	Yi, Quanyong; Zhao, Yitian
作者单位	1.Cixi Biomedical Research Institute,Wenzhou Medical University,Ningbo,China; 2.Institute of Biomedical Engineering,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo,China; 3.The Affiliated Ningbo Eye Hospital of Wenzhou Medical University,Ningbo,China; 4.Department of Neurology,West China Hospital,Sichuan University,Chengdu,China; 5.Health Science Center,Ningbo University,Ningbo,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学; 其他_附属宁波市眼科医院
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Wang, Xingguo,Zhang, Yanyan,Ma, Yuhui,et al. Automated evaluation of retinal hyperreflective foci changes in diabetic macular edema patients before and after intravitreal injection[J]. FRONTIERS IN MEDICINE,2023,10.
APA	Wang, Xingguo., Zhang, Yanyan., Ma, Yuhui., Kwapong, William Robert., Ying, Jianing., ... & Zhao, Yitian. (2023). Automated evaluation of retinal hyperreflective foci changes in diabetic macular edema patients before and after intravitreal injection. FRONTIERS IN MEDICINE, 10.
MLA	Wang, Xingguo,et al."Automated evaluation of retinal hyperreflective foci changes in diabetic macular edema patients before and after intravitreal injection".FRONTIERS IN MEDICINE 10(2023).