New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics

doi:10.3389/fendo.2023.1230168

科研成果详情

题名	New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics
作者	Wang, Shengnan 1; Zhao, Haiyang 2; Lin, Suxian 1; Lv, Yang1; Lin, Yue3; Liu, Yinai 2; Peng, Renyi 2; Jin, Huanzhi 3
发表日期	2023-08-21
发表期刊	Frontiers in endocrinology 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	diabetic complications mitochondrial dynamics mitochondrial fission mitochondrial fusion type II diabetes
其他关键词	OXIDATIVE STRESS ; MOLECULAR-MECHANISMS ; MAMMALIAN HOMOLOGS ; INSULIN-RESISTANCE ; MITOFUSIN 2 ; CELL-DEATH ; FISSION ; FUSION ; OPA1 ; MITOPHAGY
摘要	As important organelles of energetic and metabolism, changes in the dynamic state of mitochondria affect the homeostasis of cellular metabolism. Mitochondrial dynamics include mitochondrial fusion and mitochondrial fission. The former is coordinated by mitofusin-1 (Mfn1), mitofusin-2 (Mfn2), and optic atrophy 1 (Opa1), and the latter is mediated by dynamin related protein 1 (Drp1), mitochondrial fission 1 (Fis1) and mitochondrial fission factor (MFF). Mitochondrial fusion and fission are generally in dynamic balance and this balance is important to preserve the proper mitochondrial morphology, function and distribution. Diabetic conditions lead to disturbances in mitochondrial dynamics, which in return causes a series of abnormalities in metabolism, including decreased bioenergy production, excessive production of reactive oxygen species (ROS), defective mitophagy and apoptosis, which are ultimately closely linked to multiple chronic complications of diabetes. Multiple researches have shown that the incidence of diabetic complications is connected with increased mitochondrial fission, for example, there is an excessive mitochondrial fission and impaired mitochondrial fusion in diabetic cardiomyocytes, and that the development of cardiac dysfunction induced by diabetes can be attenuated by inhibiting mitochondrial fission. Therefore, targeting the restoration of mitochondrial dynamics would be a promising therapeutic target within type II diabetes (T2D) and its complications. The molecular approaches to mitochondrial dynamics, their impairment in the context of T2D and its complications, and pharmacological approaches targeting mitochondrial dynamics are discussed in this review and promise benefits for the therapy of T2D and its comorbidities.
资助项目	This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
出版者	FRONTIERS MEDIA SA
ISSN	1664-2392
卷号	14
DOI	10.3389/fendo.2023.1230168
页数	16
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001057663600001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37670891
SCOPUSEID	2-s2.0-85169693177
通讯作者地址	[Liu, Yinai]College of Life and Environmental Science,Wenzhou University,ZhejiangWenzhou,China ; [Peng, Renyi]Institute of Life Sciences & Biomedicine Collaborative Innovation Center of Zhejiang,College of Life and Environmental Science,Wenzhou University,Wenzhou,China ; [Jin, Huanzhi]General Practitioner,The Third Affiliated Hospital of Shanghai University,Wenzhou No.3 Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou People’s Hospital,Wenzhou,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182769
专题	其他_附属第三医院（瑞安市人民医院）
通讯作者	Liu, Yinai; Peng, Renyi; Jin, Huanzhi
作者单位	1.Department of Rheumatology and Immunology,The Third Affiliated Hospital of Shanghai University,Wenzhou No.3 Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou People’s Hospital,Wenzhou,China; 2.Institute of Life Sciences & Biomedicine Collaborative Innovation Center of Zhejiang,College of Life and Environmental Science,Wenzhou University,Wenzhou,China; 3.General Practitioner,The Third Affiliated Hospital of Shanghai University,Wenzhou No.3 Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou People’s Hospital,Wenzhou,China
第一作者单位	其他_附属第三医院（瑞安市人民医院）
通讯作者单位	其他_附属第三医院（瑞安市人民医院）
第一作者的第一单位	其他_附属第三医院（瑞安市人民医院）
推荐引用方式 GB/T 7714	Wang, Shengnan,Zhao, Haiyang,Lin, Suxian,et al. New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics[J]. Frontiers in endocrinology,2023,14.
APA	Wang, Shengnan., Zhao, Haiyang., Lin, Suxian., Lv, Yang., Lin, Yue., ... & Jin, Huanzhi. (2023). New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics. Frontiers in endocrinology, 14.
MLA	Wang, Shengnan,et al."New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics".Frontiers in endocrinology 14(2023).