Asiaticoside Attenuates Blood-Spinal Cord Barrier Disruption by Inhibiting Endoplasmic Reticulum Stress in Pericytes After Spinal Cord Injury

doi:10.1007/s12035-023-03605-3

科研成果详情

题名	Asiaticoside Attenuates Blood-Spinal Cord Barrier Disruption by Inhibiting Endoplasmic Reticulum Stress in Pericytes After Spinal Cord Injury
作者	Hu, Zhenxin 1; Wu, Tingting 2; Zhou, Ziheng 2; Zhang, Yu3; Chen, Qiyue2; Yao, Hanbing2; Ji, Mengchu 2; Shen, Ge 2; Dong, Chenling 2; Shi, Chengge2; Huang, Zhixian 2; Jiang, Nizhou 1; Han, Nan 4; Tian, Xiliang 1
发表日期	2023-09-01
发表期刊	Molecular neurobiology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Asiaticoside Blood–spinal cord barrier Endoplasmic reticulum stress Pericytes Spinal cord injury
其他关键词	BRAIN-BARRIER ; ISCHEMIA-REPERFUSION ; BSCB DISRUPTION ; SURVIVAL ; HYPOXIA
摘要	The blood-spinal cord barrier (BSCB) plays a vital role in the recovery of spinal cord function after spinal cord injury (SCI). Pericytes, pluripotent members of the neurovascular unit (NVU), receive signals from neighboring cells and are critical for maintaining CNS function. Therapeutic targets for the BSCB include endothelial cells (ECs) and glial cells, but few drugs target pericytes. This study was designed to explore whether asiaticoside has a positively effect on pericytes and the integrity of the BSCB. In this study, we found that asiaticoside could inhibit the loss of junction proteins just 1 day after SCI in vivo, but our in vitro study showed no significant differences in the expression of endothelial junction proteins between the control and asiaticoside treatment groups. We also found that asiaticoside could inhibit endoplasmic reticulum (ER) stress and pericyte apoptosis, which might be associated with the inhibition of junction protein reduction in ECs. Thus, we investigated the interactions between pericytes and ECs. Our results showed that asiaticoside could decrease the release of matrix metalloproteinase (MMP)-9 in pericytes and therefore upregulate the expression of junction proteins in ECs. Furthermore, the protective effect of asiaticoside on pericytes is related to the inhibition of ER stress via the MAPK signaling pathway. Taken together, our results demonstrate that asiaticoside treatment inhibits BSCB disruption and enhances functional recovery after SCI.
资助项目	National Natural Science Foundation of China [81403229]
出版者	SPRINGER
ISSN	0893-7648
EISSN	1559-1182
卷号	61 期号:2 页码:678-692
DOI	10.1007/s12035-023-03605-3
页数	15
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:001061918200001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37653222
SCOPUSEID	2-s2.0-85169164491
通讯作者地址	[Tian, Xiliang]Department of Orthopedics,The First Affiliated Hospital of Dalian Medical University,Dalian,116011,China ; [Han, Nan]Department of Ultrasonography,The First Affiliated Hospital of Dalian Medical University,Dalian,116011,China
Scopus学科分类	Neuroscience (miscellaneous);Neurology;Cellular and Molecular Neuroscience
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182726
专题	第一临床医学院（信息与工程学院）、附属第一医院其他_温州医科大学慈溪生物医药研究院
通讯作者	Han, Nan; Tian, Xiliang
作者单位	1.Department of Orthopedics,The First Affiliated Hospital of Dalian Medical University,Dalian,116011,China; 2.The First Clinical Medical College,Wenzhou Medical University,Wenzhou,325035,China; 3.Cixi Biomedical Research Institute,Wenzhou Medical University,Ningbo,315302,China; 4.Department of Ultrasonography,The First Affiliated Hospital of Dalian Medical University,Dalian,116011,China
推荐引用方式 GB/T 7714	Hu, Zhenxin,Wu, Tingting,Zhou, Ziheng,et al. Asiaticoside Attenuates Blood-Spinal Cord Barrier Disruption by Inhibiting Endoplasmic Reticulum Stress in Pericytes After Spinal Cord Injury[J]. Molecular neurobiology,2023,61(2):678-692.
APA	Hu, Zhenxin., Wu, Tingting., Zhou, Ziheng., Zhang, Yu., Chen, Qiyue., ... & Tian, Xiliang. (2023). Asiaticoside Attenuates Blood-Spinal Cord Barrier Disruption by Inhibiting Endoplasmic Reticulum Stress in Pericytes After Spinal Cord Injury. Molecular neurobiology, 61(2), 678-692.
MLA	Hu, Zhenxin,et al."Asiaticoside Attenuates Blood-Spinal Cord Barrier Disruption by Inhibiting Endoplasmic Reticulum Stress in Pericytes After Spinal Cord Injury".Molecular neurobiology 61.2(2023):678-692.