Predictive Value of D-dimer in Preeclamptic Pregnant Women at Different Ages

doi:10.31083/j.ceog5007142

科研成果详情

题名	Predictive Value of D-dimer in Preeclamptic Pregnant Women at Different Ages
作者	Liao, Tingting 1; Hu, Yanjun 2; Chen, Shihao 3; Zheng, Jiayong 4; Zhang, Hongping 2
发表日期	2023-07
发表期刊	CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	D-dimer fibrinogen fetal weight preeclampsia
其他关键词	FIBRIN D-DIMER ; PROTEIN
摘要	Background: The aim of this study was to evaluate the relationship and impact of D-dimer levels and preeclamptic pregnancies at different ages in women. Methods: We conducted an observational retrospective cohort study of 325 pregnant women who delivered in Wenzhou People's Hospital from January 2018 to December 2021. Clinical data including age, neutrophils, lymphocytes, platelets, fibrinogen, gestational age, D-dimer/fibrinogen, blood pressure at admission, and fetal weight were collected from the medical record database. All measurements were made using the same methods. Data for continuous variables were expressed as X & PLUSMN; standard deviation (SD), and inter-group differences in continuous data were compared by independent sample t-test. Continuous variables that do not conform to the normal distribution, such as age and D-dimer, were expressed as median and quartile ranges. The relationship between D-dimer and preeclampsia pregnant women of different ages was evaluated by receiver operating characteristics (ROC) curve analysis. Results: Among the middle-aged pregnant women, the average D-dimer in the normotensive pregnancy group was (1.367 & PLUSMN; 0.03 mg/L), which was significantly lower than that in the preeclampsia group (2.087 & PLUSMN; 0.16 mg/L). The D-dimer/fibrinogen ratio was comparable between the young groups, but there was a difference between the middle-aged groups. Meanwhile, in middle-aged pregnant women, the predicted area of D-dimer for preeclampsia was 70.2% (95% confidence interval (CI) 60-80.43%, p = 0.0002) , which was significantly higher than that in the young group. Conclusions: Prenatal D-dimer levels may be associated with more accurate predictors of preeclampsia in middle-aged women than in young women.
资助项目	Wenzhou Science and Technology Bureau [Y20210027]
出版者	IMR PRESS
ISSN	0390-6663
EISSN	2709-0094
卷号	50 期号:7
DOI	10.31083/j.ceog5007142
页数	6
WOS类目	Obstetrics & Gynecology
WOS研究方向	Obstetrics & Gynecology
WOS记录号	WOS:001044957800017
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85167398876
通讯作者地址	[Zhang, Hongping]Department of Obstetric,Wenzhou People's Hospital,Zhejiang,Wenzhou,325000,China
Scopus学科分类	Reproductive Medicine;Obstetrics and Gynecology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182351
专题	第二临床医学院、附属第二医院、育英儿童医院_神经病学
通讯作者	Zhang, Hongping
作者单位	1.Department of Obstetrics and Gynecology,Wenzhou People's Hospital,Zhejiang,Wenzhou,325000,China; 2.Department of Obstetric,Wenzhou People's Hospital,Zhejiang,Wenzhou,325000,China; 3.Department of Neurology,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 4.Department of Reproductive Genetics,Wenzhou People's Hospital,Zhejiang,Wenzhou,325000,China
推荐引用方式 GB/T 7714	Liao, Tingting,Hu, Yanjun,Chen, Shihao,et al. Predictive Value of D-dimer in Preeclamptic Pregnant Women at Different Ages[J]. CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY,2023,50(7).
APA	Liao, Tingting, Hu, Yanjun, Chen, Shihao, Zheng, Jiayong, & Zhang, Hongping. (2023). Predictive Value of D-dimer in Preeclamptic Pregnant Women at Different Ages. CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 50(7).
MLA	Liao, Tingting,et al."Predictive Value of D-dimer in Preeclamptic Pregnant Women at Different Ages".CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY 50.7(2023).