3D-printed porous functional composite scaffolds with polydopamine decoration for bone regeneration

doi:10.1093/rb/rbad062

科研成果详情

题名	3D-printed porous functional composite scaffolds with polydopamine decoration for bone regeneration
作者	Qi, Jin 1,2,3; Wang, Yili 1,2; Chen, Liping1,2; Chen, Linjie4; Wen, Feng1,2; Huang, Lijiang5; Rueben, Pfukwa 6; Zhang, Chunwu1; Li, Huaqiong1,2
发表日期	2023-01-17
发表期刊	REGENERATIVE BIOMATERIALS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	3D printing bioactive glass composites polydopamine angiogenesis bone regeneration
其他关键词	IN-VITRO ; MECHANICAL-PROPERTIES ; DEGRADATION ; BIOMATERIAL ; CONSTRUCTS ; SURFACE
摘要	Large size bone defects affect human health and remain a worldwide health problem that needs to be solved immediately. 3D printing technology has attracted substantial attention for preparing penetrable multifunctional scaffolds to promote bone reconditioning and regeneration. Inspired by the spongy structure of natural bone, novel porous degradable scaffolds have been printed using polymerization of lactide and caprolactone (PLCL) and bioactive glass 45S5 (BG), and polydopamine (PDA) was used to decorate the PLCL/BG scaffolds. The physicochemical properties of the PLCL/BG and PLCL/BG/PDA scaffolds were measured, and their osteogenic and angiogenic effects were characterized through a series of experiments both in vitro and in vivo. The results show that the PLCL/BG2/PDA scaffold possessed a good compression modulus and brilliant hydrophilicity. The proliferation, adhesion and osteogenesis of hBMSCs were improved in the PDA coating groups, which exhibited the best performance. The results of the SD rat cranium defect model indicate that PLCL/BG2/PDA obviously promoted osteointegration, which was further confirmed through immunohistochemical staining. Therefore, PDA decoration and the sustained release of bioactive ions (Ca, Si, P) from BG in the 3D-printed PLCL/BG2/PDA scaffold could improve surface bioactivity and promote better osteogenesis and angiogenesis, which may provide a valuable basis for customized implants in extensive bone defect repair applications.
资助项目	Wenzhou Institute, University of Chinese Academy of Sciences [WIUCASQD2019002, WIUCASZZXF21005]; First Affiliated Hospital of Wenzhou Medical University
出版者	OXFORD UNIV PRESS
ISSN	2056-3418
EISSN	2056-3426
卷号	10
DOI	10.1093/rb/rbad062
页数	15
WOS类目	Materials Science, Biomaterials
WOS研究方向	Materials Science
WOS记录号	WOS:001038207100001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20233414585424
EI主题词	Bioactive glass
EI分类号	405.1 Construction Equipment ; 462.5 Biomaterials (including synthetics) ; 745.1.1 Printing Equipment ; 801.4 Physical Chemistry ; 812.3 Glass
URL	查看原文
PubMed ID	37520855
SCOPUSEID	2-s2.0-85168101094
通讯作者地址	[Zhang, Chunwu]Department of Orthopaedics,Joint Centre of Translational Medicine,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325035,China ; [Li, Huaqiong]Department of Orthopaedics,Joint Centre of Translational Medicine,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
Scopus学科分类	Biomaterials
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182291
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院附属第一医院其他_附属象山医院（象山县第一人民医院）其他_附属萧山医院（杭州市萧山区第一人民医院）
通讯作者	Zhang, Chunwu; Li, Huaqiong
作者单位	1.Department of Orthopaedics,Joint Centre of Translational Medicine,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 2.Joint Centre of Translational Medicine,Zhejiang Engineering Research Center for Tissue Repair Materials,Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,325011,China; 3.University of Chinese Academy of Sciences,Beijing,100049,China; 4.The Second Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 5.The Affiliated Xiangshan Hospital of Wenzhou Medical University,Zhejiang,Ningbo,315700,China; 6.Department of Chemistry and Polymer Science,Stellenbosch University,Matieland, Stellenbosch,7602,South Africa
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Qi, Jin,Wang, Yili,Chen, Liping,et al. 3D-printed porous functional composite scaffolds with polydopamine decoration for bone regeneration[J]. REGENERATIVE BIOMATERIALS,2023,10.
APA	Qi, Jin., Wang, Yili., Chen, Liping., Chen, Linjie., Wen, Feng., ... & Li, Huaqiong. (2023). 3D-printed porous functional composite scaffolds with polydopamine decoration for bone regeneration. REGENERATIVE BIOMATERIALS, 10.
MLA	Qi, Jin,et al."3D-printed porous functional composite scaffolds with polydopamine decoration for bone regeneration".REGENERATIVE BIOMATERIALS 10(2023).