Effects of Dechlorane Plus exposure on axonal growth, musculature and motor behavior in embryo-larval zebrafish

doi:10.1016/j.envpol.2017.03.011

科研成果详情

题名	Effects of Dechlorane Plus exposure on axonal growth, musculature and motor behavior in embryo-larval zebrafish
作者	Chen, Xiangping 1; Dong, Qiaoxiang2; Chen, Yuanhong2; Zhang, Zhenxuan 1; Huang, Changjiang 2; Zhu, Yaxian 3; Zhang, Yong 1
发表日期	2017-05
发表期刊	ENVIRONMENTAL POLLUTION 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Dechlorane plus Zebrafish Motor behavior Neurobehavioral toxicity
其他关键词	DANIO-RERIO ; LOCOMOTOR NETWORK ; FLAME RETARDANTS ; ADULT ZEBRAFISH ; CHINA ; RESPONSES ; SYSTEMS ; ETHER
摘要	Developmental neurobehavioral toxicity of Dechlorane Plus (DP) was investigated using the embryo larval stages of zebrafish (Danio rerio). Normal fertilized embryos were waterborne exposed to DP at 15, 30, 60 mu g/L beginning from 6 h post-fertilization (hpf). Larval teratology, motor activity, motoneuron axonal growth and muscle morphology were assessed at different developmental stages. Results showed that DP exposure significantly altered embryonic spontaneous movement, reduced touch-induced movement and free-swimming speed and decreased swimming speed of larvae in response to dark stimulation. These changes occurred at DP doses that resulted no significant teratogenesis in zebrafish. Interestingly, in accord with these behavioral anomalies, DP exposure significantly inhibited axonal growth of primary motoneuron and induced apoptotic cell death and lesions in the muscle fibers of zebrafish. Furthermore, DP exposure at 30 mu g/L and 60 mu g/L significantly increased reactive oxygen species (ROS) and malondialdehyde (MDA) formation, as well as the mRNA transcript levels of apoptosis-related genes box and caspase-3. Together, our data indicate that DP induced neurobehavioral deficits may result from combined effects of altered neuronal connectivity and muscle injuries. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目	Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21177102, 21577110]; Research Fund for the Doctoral Program of Higher Education of ChinaResearch Fund for the Doctoral Program of Higher Education of China (RFDP)Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20130121130005]
出版者	ELSEVIER SCI LTD
出版地	OXFORD
ISSN	0269-7491
EISSN	1873-6424
卷号	224 页码:7-15
DOI	10.1016/j.envpol.2017.03.011
页数	39
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
WOS记录号	WOS:000399261400002
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20171103438472
EI主题词	Neurons
URL	查看原文
PubMed ID	28288352
SCOPUSEID	2-s2.0-85014911339
通讯作者地址	[Zhang, Yong]State Key Laboratory of Marine Environmental Science of China (Xiamen University),College of Environment and Ecology,Xiamen University,Xiamen,361102,China
Scopus学科分类	Toxicology;Pollution;Health, Toxicology and Mutagenesis
TOP期刊	TOP期刊
引用统计	被引频次：38[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18205
专题	公共卫生学院_健康与环境生态研究所公共卫生学院_环境安全与健康风险评估研究院
通讯作者	Zhang, Yong
作者单位	1.State Key Laboratory of Marine Environmental Science of China (Xiamen University),College of the Environment and Ecology,Xiamen University,Xiamen,361102,China; 2.Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China; 3.Department of Chemistry,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen,361005,China
推荐引用方式 GB/T 7714	Chen, Xiangping,Dong, Qiaoxiang,Chen, Yuanhong,et al. Effects of Dechlorane Plus exposure on axonal growth, musculature and motor behavior in embryo-larval zebrafish[J]. ENVIRONMENTAL POLLUTION,2017,224:7-15.
APA	Chen, Xiangping., Dong, Qiaoxiang., Chen, Yuanhong., Zhang, Zhenxuan., Huang, Changjiang., ... & Zhang, Yong. (2017). Effects of Dechlorane Plus exposure on axonal growth, musculature and motor behavior in embryo-larval zebrafish. ENVIRONMENTAL POLLUTION, 224, 7-15.
MLA	Chen, Xiangping,et al."Effects of Dechlorane Plus exposure on axonal growth, musculature and motor behavior in embryo-larval zebrafish".ENVIRONMENTAL POLLUTION 224(2017):7-15.