A novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer

doi:10.1186/s13045-023-01459-9

科研成果详情

名称	A novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer
作者	Liu, Jiaqi 1,2; Chen, Haibin 3; Li, Yalun 4; Fang, Yanman 5; Guo, Yang 6; Li, Shuangquan 7; Xu, Juan 8; Jia, Ziqi 1; Zou, Jiali 5; Liu, Gang 1; Xu, Hengyi 1,9; Wang, Tao 10; Wang, Dingyuan 1; Jiang, Yiwen 1,9; Wang, Yang 1; Tang, Xuejie 5; Qiao, Guangdong 4; Zhou, Yeqing 4; Bai, Lan 8; Zhou, Ran 6; Lu, Can 8; Wen, Hongwei 6; Li, Jiayi 1,9; Huang, Yansong 1,9; Zhang, Shuo 11; Feng, Yong 3; Chen, Hongyan 2; Xu, Shouping 12; Zhang, Bailin 1; Liu, Zhihua 2; Wang, Xiang 1
发表期刊	JOURNAL OF HEMATOLOGY & ONCOLOGY
语种	英语
原始文献类型	Letter
关键词	Breast cancer Breath test Volatile organic compound Early diagnosis Cancer screening
摘要	Background Early detection is critical for improving the survival of breast cancer (BC) patients. Exhaled breath testing as a non-invasive technique might help to improve BC detection. However, the breath test accuracy for BC diagnosis is unclear.Methods This multi-center cohort study consecutively recruited 5047 women from four areas of China who underwent BC screening. Breath samples were collected through standardized breath collection procedures. Volatile organic compound (VOC) markers were identified from a high-throughput breathomics analysis by the high-pressure photon ionization-time-of-flight mass spectrometry (HPPI-TOFMS). Diagnostic models were constructed using the random forest algorithm in the discovery cohort and tested in three external validation cohorts.Results A total of 465 (9.21%) participants were identified with BC. Ten optimal VOC markers were identified to distinguish the breath samples of BC patients from those of non-cancer women. A diagnostic model (BreathBC) consisting of 10 optimal VOC markers showed an area under the curve (AUC) of 0.87 in external validation cohorts. BreathBC-Plus, which combined 10 VOC markers with risk factors, achieved better performance (AUC = 0.94 in the external validation cohorts), superior to that of mammography and ultrasound. Overall, the BreathBC-Plus detection rates were 96.97% for ductal carcinoma in situ, 85.06%, 90.00%, 88.24%, and 100% for stages I, II, III, and IV BC, respectively, with a specificity of 87.70% in the external validation cohorts.Conclusions This is the largest study on breath tests to date. Considering the easy-to-perform procedure and high accuracy, these findings exemplify the potential applicability of breath tests in BC screening.
资助项目	Beijing Hope Run Special Fund[LC2020B05];National Natural Science Foundation of China[82272938];CAMS Innovation Fund for Medical Sciences[2021-I2M-1-014,T-A-015];Beijing Nova Program[20220484059];
出版者	BMC
ISSN	1756-8722
EISSN	1756-8722
卷号	16
期号	1
DOI	10.1186/s13045-023-01459-9
页数	5
WOS类目	Oncology ; Hematology
WOS研究方向	Oncology ; Hematology
WOS记录号	WOS:001013588800001
收录类别	SCIE ; SCOPUS
发布日期	2023-06-16
URL	查看原文
PubMed ID	37328852
通讯作者地址	[Zhang, Bailin;Wang, Xiang]Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, Dept Breast Surg Oncol,Canc Hosp, 17 Panjiayuannanli, Beijing 100021, Peoples R China. ; [Liu, Zhihua]Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, State Key Lab Mol Oncol,Canc Hosp, 17 Panjiayuannanli, Beijing 100021, Peoples R China.
Scopus学科分类	Hematology;Molecular Biology;Oncology;Cancer Research
SCOPUSEID	SCOPUS_ID:85162148001
TOP期刊	TOP期刊
引用统计
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181662
专题	第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科
通讯作者	Zhang, Bailin; Liu, Zhihua; Wang, Xiang
作者单位	1.Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, Dept Breast Surg Oncol,Canc Hosp, 17 Panjiayuannanli, Beijing 100021, Peoples R China; 2.Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, State Key Lab Mol Oncol,Canc Hosp, 17 Panjiayuannanli, Beijing 100021, Peoples R China; 3.PCAB Res Ctr Breath & Metab, Breax Lab, Beijing 100071, Peoples R China; 4.Qingdao Univ, Yantai Yuhuangding Hosp, Dept Breast Surg, Yantai 264000, Peoples R China; 5.Guiyang Maternal & Child Healthcare Hosp, Dept Breast Surg, Guiyang 550001, Peoples R China; 6.Yanqing Maternal & Child Healthcare Hosp Beijing, Dept Breast Surg, Beijing 101399, Peoples R China; 7.Wenzhou Med Univ, Affiliated Hosp 1, Dept Radiol, Wenzhou 325000, Peoples R China; 8.Daxing Maternal & Child Healthcare Hosp Beijing, Dept Breast Surg, Beijing 100162, Peoples R China; 9.Chinese Acad Med Sci & Peking Union Med Coll, Beijing 100005, Peoples R China; 10.Capital Med Univ, Xuanwu Hosp, China Int Neurosci Inst, Natl Ctr Neurol Disorders,Dept Neurosurg, Beijing 100053, Peoples R China; 11.Hebei Med Univ, Hosp 4, Dept Breast Surg, Shijiazhuang 050019, Hebei, Peoples R China; 12.Harbin Med Univ, Canc Hosp, Dept Breast Surg, Harbin 150081, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jiaqi,Chen, Haibin,Li, Yalun,et al. A novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer. 2023.