A novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer

doi:10.1186/s13045-023-01459-9

科研成果详情

题名	A novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer
作者	Jiaqi Liu 1,2; Haibin Chen 3; Yalun Li 4; Yanman Fang 5; Yang Guo 6; Shuangquan Li 7; Juan Xu 8; Ziqi Jia 1; Jiali Zou 5; Gang Liu 1; Hengyi Xu 1,9; Tao Wang 10; Dingyuan Wang 1; Yiwen Jiang 1,9; Yang Wang 1; Xuejie Tang 5; Guangdong Qiao 4; Yeqing Zhou 4; Lan Bai 8; Ran Zhou 6; Can Lu 8; Hongwei Wen 6; Jiayi Li 1,9; Yansong Huang 1,9; Shuo Zhang 11; Yong Feng 3; Hongyan Chen 2; Shouping Xu 12; Bailin Zhang 13; Zhihua Liu 14; Xiang Wang 15
发表日期	2023-06-16
发表期刊	Journal of hematology & oncology 影响因子和分区
语种	英语
原始文献类型	Multicenter Study ; Letter
关键词	Breast cancer Breath test Cancer screening Early diagnosis Volatile organic compound
摘要	Early detection is critical for improving the survival of breast cancer (BC) patients. Exhaled breath testing as a non-invasive technique might help to improve BC detection. However, the breath test accuracy for BC diagnosis is unclear., This multi-center cohort study consecutively recruited 5047 women from four areas of China who underwent BC screening. Breath samples were collected through standardized breath collection procedures. Volatile organic compound (VOC) markers were identified from a high-throughput breathomics analysis by the high-pressure photon ionization-time-of-flight mass spectrometry (HPPI-TOFMS). Diagnostic models were constructed using the random forest algorithm in the discovery cohort and tested in three external validation cohorts., A total of 465 (9.21%) participants were identified with BC. Ten optimal VOC markers were identified to distinguish the breath samples of BC patients from those of non-cancer women. A diagnostic model (BreathBC) consisting of 10 optimal VOC markers showed an area under the curve (AUC) of 0.87 in external validation cohorts. BreathBC-Plus, which combined 10 VOC markers with risk factors, achieved better performance (AUC = 0.94 in the external validation cohorts), superior to that of mammography and ultrasound. Overall, the BreathBC-Plus detection rates were 96.97% for ductal carcinoma in situ, 85.06%, 90.00%, 88.24%, and 100% for stages I, II, III, and IV BC, respectively, with a specificity of 87.70% in the external validation cohorts., This is the largest study on breath tests to date. Considering the easy-to-perform procedure and high accuracy, these findings exemplify the potential applicability of breath tests in BC screening.
资助项目	Beijing Hope Run Special Fund[LC2020B05];National Natural Science Foundation of China[82272938];Beijing Nova Program[20220484059];CAMS Innovation Fund for Medical Sciences[2021-I2M-1-014 and 2021-I2M-C&T-A-015];CAMS Innovation Fund for Medical Sciences[2021-I2M-1-014 and 2021-I2M-C&T-A-015]
ISSN	1756-8722
卷号	16 期号:1
DOI	10.1186/s13045-023-01459-9
收录类别	PUBMED
URL	查看原文
PubMed ID	37328852
自科自定义期刊分类	T3(B)类
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181180
专题	第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科
作者单位	1.Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang, Beijing, 100021, People's Republic of China.; 2.State Key Laboratory of Molecular Oncology, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang, Beijing, 100021, People's Republic of China.; 3.Breax Laboratory, PCAB Research Center of Breath and Metabolism, Beijing, 100071, People's Republic of China.; 4.Department of Breast Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000, People's Republic of China.; 5.Department of Breast Surgery, Guiyang Maternal and Child Healthcare Hospital, Guiyang, 550001, People's Republic of China.; 6.Department of Breast Surgery, Yanqing Maternal and Child Healthcare Hospital of Beijing, Beijing, 101399, People's Republic of China.; 7.Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China.; 8.Department of Breast Surgery, Daxing Maternal and Child Healthcare Hospital of Beijing, Beijing, 100162, People's Republic of China.; 9.Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100005, People's Republic of China.; 10.Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience Institute, National Center for Neurological Disorders, Capital Medical University, Beijing, 100053, People's Republic of China.; 11.Department of Breast Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050019, Hebei, People's Republic of China.; 12.Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, People's Republic of China.; 13.Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang, Beijing, 100021, People's Republic of China. bailin_zhang@cicams.ac.cn.; 14.State Key Laboratory of Molecular Oncology, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang, Beijing, 100021, People's Republic of China. liuzh@cicams.ac.cn.; 15.Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang, Beijing, 100021, People's Republic of China. xiangw@vip.sina.com.
推荐引用方式 GB/T 7714	Jiaqi Liu,Haibin Chen,Yalun Li,et al. A novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer[J]. Journal of hematology & oncology,2023,16(1).
APA	Jiaqi Liu., Haibin Chen., Yalun Li., Yanman Fang., Yang Guo., ... & Xiang Wang. (2023). A novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer. Journal of hematology & oncology, 16(1).
MLA	Jiaqi Liu,et al."A novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer".Journal of hematology & oncology 16.1(2023).