Crucial roles of Rab22a in endosomal cargo recycling

doi:10.1111/tra.12907

科研成果详情

题名	Crucial roles of Rab22a in endosomal cargo recycling
作者	Kong, Lingjie1; Huang, Shenghao 1; Bao, Yuxuan1; Chen, Yingtong 1; Hua, Chunyan2; Gao, Sheng 3
发表日期	2023-09
发表期刊	TRAFFIC 影响因子和分区
语种	英语
原始文献类型	Review ; Early Access
关键词	cargo recycling endosomal traffic Rab GTPase Rab22a recycling tubule
其他关键词	MUSCARINIC ACETYLCHOLINE-RECEPTORS ; DOMAIN-CONTAINING PROTEINS ; NUCLEOTIDE EXCHANGE FACTOR ; NEURITE OUTGROWTH ; PLASMA-MEMBRANE ; GOLGI-APPARATUS ; CELL-MIGRATION ; TRAFFICKING ; TRANSPORT ; RAB5
摘要	Endosomal cargo recycling lies at the heart of subcellular trafficking processes under the management of several Ras-related GTP-binding proteins (Rabs) which are coordinated by their upstream regulators and require their downstream effectors to display their functions. In this regard, several Rabs have been well-reviewed except Rab22a. Rab22a is a crucial regulator of vesicle trafficking, early endosome and recycling endosome formation. Notably, recent studies demonstrated the immunological roles of Rab22a, which are closely associated with cancers, infection and autoimmune disorders. This review provides an overview of the regulators and effectors of Rab22a. Also, we highlight the current knowledge of the role of Rab22a in endosomal cargo recycling, including the biogenesis of recycling tubules with the help of a complex with Rab22a at its core, and how different internalized cargo chooses different recycling routes thanks to the cooperation of Rab22a, its effectors and its regulators. Of note, contradictions and speculation related to endosomal cargo recycling that Rab22a brings impacts on are also discussed. Finally, this review endeavors to briefly introduce the various events impacted by Rab22a, particularly focusing on the commandeered Rab22a-associated endosomal maturation and endosomal cargo recycling, in addition to the extensively investigated oncogenic role of Rab22a.
资助项目	National Natural Science Foundation of China[81901660];Zhejiang Province Natural Science Foundation[LTGY23H100001];Science and Technology Plan Project of Wenzhou[Y20220045,Y20220389];
出版者	WILEY
ISSN	1398-9219
EISSN	1600-0854
卷号	24 期号:9 页码:397-412
DOI	10.1111/tra.12907
页数	16
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:001009587900001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-06
URL	查看原文
PubMed ID	37340959
SCOPUSEID	2-s2.0-85162657396
通讯作者地址	[Hua, Chunyan]School of Basic Medical Sciences,Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China ; [Gao, Sheng]Laboratory Animal Center,Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China
Scopus学科分类	Structural Biology;Biochemistry;Molecular Biology;Genetics;Cell Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181096
专题	温州医科大学基础医学院（机能实验教学中心）实验动物中心
通讯作者	Hua, Chunyan; Gao, Sheng
作者单位	1.School of the 2nd Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China; 2.School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou,China; 3.Laboratory Animal Center,Wenzhou Medical University,Wenzhou,China
第一作者单位	温州医科大学
通讯作者单位	基础医学院（机能实验教学中心）; 实验动物中心
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Kong, Lingjie,Huang, Shenghao,Bao, Yuxuan,et al. Crucial roles of Rab22a in endosomal cargo recycling[J]. TRAFFIC,2023,24(9):397-412.
APA	Kong, Lingjie, Huang, Shenghao, Bao, Yuxuan, Chen, Yingtong, Hua, Chunyan, & Gao, Sheng. (2023). Crucial roles of Rab22a in endosomal cargo recycling. TRAFFIC, 24(9), 397-412.
MLA	Kong, Lingjie,et al."Crucial roles of Rab22a in endosomal cargo recycling".TRAFFIC 24.9(2023):397-412.