科研成果详情

题名SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease
作者
发表日期2023-05-25
发表期刊AGING AND DISEASE   影响因子和分区
语种英语
原始文献类型Article ; Early Access
关键词Alzheimer's disease SARM1 degeneration inflammation memory
其他关键词NEUROINFLAMMATION ; TNF ; ACTIVATION ; DEGENERATION ; DELETION
摘要Neuroinflammation plays a crucial role in the pathogenesis and progression of Alzheimer's disease (AD). The Sterile Alpha and Toll Interleukin Receptor Motif-containing protein 1 (SARM1) has been shown to promote axonal degeneration and is involved in neuroinflammation. However, the role of SARM1 in AD remains unclear. In this study, we found that SARM1 was reduced in hippocampal neurons of AD model mice. Interestingly, conditional knockout (CKO) of SARM1 in the central nervous system (CNS, SARM1(Nestin)-CKO mice) delayed the cognitive decline in APP/PS1 AD model mice. Furthermore, SARM1 deletion reduced the A beta deposition and inflammatory infiltration in the hippocampus and inhibited neurodegeneration in APP/PS1 AD model mice. Further investigation into the underlying mechanisms revealed that the signaling of tumor necrosis factor-alpha (TNF-alpha) was downregulated in the hippocampus tissues of APP/PS1;SARM1Nestin-CKO mice, thereby alleviating the cognitive decline, A beta deposition and inflammatory infiltration. These findings identify unrecognized functions of SARM1 in promoting AD and reveal the SARM1-TNF-alpha pathway in AD model mice.
资助项目Natural Science Foundation of Zhejiang Province [LR21H090001, LZ23C090001]; National Natural Science Foundation [81971172, 92049104]
出版者INT SOC AGING & DISEASE
ISSN2152-5250
卷号15期号:1页码:390-407
DOI10.14336/AD.2023.0516-1
页数18
WOS类目Geriatrics & Gerontology
WOS研究方向Geriatrics & Gerontology
WOS记录号WOS:000998058100001
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID37307837
SCOPUSEID2-s2.0-85180169637
通讯作者地址[Wang, Wei]Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Wang, Ying]Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,China
Scopus学科分类Pathology and Forensic Medicine;Geriatrics and Gerontology;Neurology (clinical);Cell Biology
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/181055
专题精神医学学院
第一临床医学院(信息与工程学院)、附属第一医院
通讯作者Wang, Wei; Wang, Ying
作者单位
1.College of Pharmacy,Hangzhou Normal University,Zhejiang,Hangzhou,311121,China;
2.School of Mental Health,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China;
3.School of the First Clinical Medical Sciences,School of Information and Engineering,Wenzhou Medical University,Zhejiang,Wenzhou,325205,China;
4.Clinical Research Center,Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,310003,China
第一作者单位精神医学学院
通讯作者单位温州医科大学
推荐引用方式
GB/T 7714
Miao, Xuemeng,Wu, Qian,Du, Siyu,et al. SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease[J]. AGING AND DISEASE,2023,15(1):390-407.
APA Miao, Xuemeng., Wu, Qian., Du, Siyu., Xiang, Ludan., Zhou, Siyao., ... & Huang, Zhihui. (2023). SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease. AGING AND DISEASE, 15(1), 390-407.
MLA Miao, Xuemeng,et al."SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease".AGING AND DISEASE 15.1(2023):390-407.

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