题名 | SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease |
作者 | |
发表日期 | 2023-05-25 |
发表期刊 | AGING AND DISEASE 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article ; Early Access |
关键词 | Alzheimer's disease SARM1 degeneration inflammation memory |
其他关键词 | NEUROINFLAMMATION ; TNF ; ACTIVATION ; DEGENERATION ; DELETION |
摘要 | Neuroinflammation plays a crucial role in the pathogenesis and progression of Alzheimer's disease (AD). The Sterile Alpha and Toll Interleukin Receptor Motif-containing protein 1 (SARM1) has been shown to promote axonal degeneration and is involved in neuroinflammation. However, the role of SARM1 in AD remains unclear. In this study, we found that SARM1 was reduced in hippocampal neurons of AD model mice. Interestingly, conditional knockout (CKO) of SARM1 in the central nervous system (CNS, SARM1(Nestin)-CKO mice) delayed the cognitive decline in APP/PS1 AD model mice. Furthermore, SARM1 deletion reduced the A beta deposition and inflammatory infiltration in the hippocampus and inhibited neurodegeneration in APP/PS1 AD model mice. Further investigation into the underlying mechanisms revealed that the signaling of tumor necrosis factor-alpha (TNF-alpha) was downregulated in the hippocampus tissues of APP/PS1;SARM1Nestin-CKO mice, thereby alleviating the cognitive decline, A beta deposition and inflammatory infiltration. These findings identify unrecognized functions of SARM1 in promoting AD and reveal the SARM1-TNF-alpha pathway in AD model mice. |
资助项目 | Natural Science Foundation of Zhejiang Province [LR21H090001, LZ23C090001]; National Natural Science Foundation [81971172, 92049104] |
出版者 | INT SOC AGING & DISEASE |
ISSN | 2152-5250 |
卷号 | 15期号:1页码:390-407 |
DOI | 10.14336/AD.2023.0516-1 |
页数 | 18 |
WOS类目 | Geriatrics & Gerontology |
WOS研究方向 | Geriatrics & Gerontology |
WOS记录号 | WOS:000998058100001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 37307837 |
SCOPUSEID | 2-s2.0-85180169637 |
通讯作者地址 | [Wang, Wei]Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Wang, Ying]Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,China |
Scopus学科分类 | Pathology and Forensic Medicine;Geriatrics and Gerontology;Neurology (clinical);Cell Biology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/181055 |
专题 | 精神医学学院 第一临床医学院(信息与工程学院)、附属第一医院 |
通讯作者 | Wang, Wei; Wang, Ying |
作者单位 | 1.College of Pharmacy,Hangzhou Normal University,Zhejiang,Hangzhou,311121,China; 2.School of Mental Health,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 3.School of the First Clinical Medical Sciences,School of Information and Engineering,Wenzhou Medical University,Zhejiang,Wenzhou,325205,China; 4.Clinical Research Center,Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,310003,China |
第一作者单位 | 精神医学学院 |
通讯作者单位 | 温州医科大学 |
推荐引用方式 GB/T 7714 | Miao, Xuemeng,Wu, Qian,Du, Siyu,et al. SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease[J]. AGING AND DISEASE,2023,15(1):390-407. |
APA | Miao, Xuemeng., Wu, Qian., Du, Siyu., Xiang, Ludan., Zhou, Siyao., ... & Huang, Zhihui. (2023). SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease. AGING AND DISEASE, 15(1), 390-407. |
MLA | Miao, Xuemeng,et al."SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease".AGING AND DISEASE 15.1(2023):390-407. |
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