Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism

doi:10.12669/pjms.39.3.7150

科研成果详情

题名	Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism
作者	Zhang, Jiajia1; Chen, Hao2; Dou, Xiaobing 3; Huang, Wei 1; Zeng, Haixia 1
发表日期	2023-05
发表期刊	Pakistan journal of medical sciences 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Blood lipids Pregnancy Pregnancy outcome Subclinical hypothyroidism Thyroid stimulating hormone
摘要	To investigate the association between gestational blood lipids and thyroid stimulating hormone (TSH) levels and pregnancy outcomes of patients with subclinical hypothyroidism (SCH)., In this retrospective observational study, we analyzed the clinical data of 82 patients (case group) with gestational SCH treated in our hospital from January 2021 to January 2022 at gestational weeks 25-33 and grouped them according to whether SCH was well controlled by treatment (case Group-A: well controlled, n=55; case Group-B: poorly controlled, n=27), and the clinical data of 41 pregnant women (control group) undergoing physical examination during the same period. After comparing the blood lipids and TSH levels of the three groups, we compared their adverse pregnancy outcomes to assess the possible correlations between blood lipids and TSH levels and pregnancy outcomes., {AbstractText=The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and TSH in the case Group-B were significantly higher than those in the case Group-A and the control group (P<0.05). Compared with case Group-B and the control group, the incidence of premature delivery, abortion and neonatal growth restriction was higher in case Group-A (P<0.05). Among 82 patients in the case group 42 presented adverse pregnancy outcomes. The levels of TC, TG, LDL-C and TSH in mothers and infants in the adverse outcome group were significantly higher than those in the favorable outcome group (P<0.05). Our Pearson analysis results showed that the levels of TC, TG and LDL-C were positively correlated with the TSH levels and the pregnancy outcomes, and that TSH was positively correlated with pregnancy outcomes (P<0.05).}, The levels of TC, TG, LDL-C and TSH in patients with poorly controlled SCH were increased during pregnancy, and were associated with the pregnancy outcomes and positively correlated with each other.
出版者	PROFESSIONAL MEDICAL PUBLICATIONS
ISSN	1681-715X
EISSN	1682-024X
卷号	39 期号:3 页码:721-725
DOI	10.12669/pjms.39.3.7150
页数	5
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000989167300019
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37250539
SCOPUSEID	2-s2.0-85150754294
通讯作者地址	[Zeng, Haixia]Department of Obstetrics,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325000,China
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180607
专题	附属第一医院_产科
通讯作者	Zeng, Haixia
作者单位	1.Department of Obstetrics,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325000,China; 2.Department of Thyroid Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325000,China; 3.Department of Pediatric Internal Medicine,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325000,China
第一作者单位	附属第一医院; 妇产科学; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 妇产科学; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhang, Jiajia,Chen, Hao,Dou, Xiaobing,et al. Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism[J]. Pakistan journal of medical sciences,2023,39(3):721-725.
APA	Zhang, Jiajia, Chen, Hao, Dou, Xiaobing, Huang, Wei, & Zeng, Haixia. (2023). Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism. Pakistan journal of medical sciences, 39(3), 721-725.
MLA	Zhang, Jiajia,et al."Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism".Pakistan journal of medical sciences 39.3(2023):721-725.