Metabolomic investigation of urinary extracellular vesicles for early detection and screening of lung cancer

doi:10.1186/s12951-023-01908-0

科研成果详情

题名	Metabolomic investigation of urinary extracellular vesicles for early detection and screening of lung cancer
作者	Yang, Qinsi 1; Luo, Jiaxin2; Xu, Hao 2; Huang, Liu 3; Zhu, Xinxi4; Li, Hengrui2; Yang, Rui2; Peng, Bo 1; Sun, Da 5; Zhu, Qingfu2; Liu, Fei6
发表日期	2023-05-16
发表期刊	Journal of nanobiotechnology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Early diagnosis Extracellular vesicles Lung cancer Metabolomics
其他关键词	EXOSOMES ; IDENTIFICATION ; BIOMARKERS ; PROTEINS
摘要	Lung cancer is a prevalent cancer type worldwide that often remains asymptomatic in its early stages and is frequently diagnosed at an advanced stage with a poor prognosis due to the lack of effective diagnostic techniques and molecular biomarkers. However, emerging evidence suggests that extracellular vesicles (EVs) may promote lung cancer cell proliferation and metastasis, and modulate the anti-tumor immune response in lung cancer carcinogenesis, making them potential biomarkers for early cancer detection. To investigate the potential of urinary EVs for non-invasive detection and screening of patients at early stages, we studied metabolomic signatures of lung cancer. Specifically, we conducted metabolomic analysis of 102 EV samples and identified metabolome profiles of urinary EVs, including organic acids and derivatives, lipids and lipid-like molecules, organheterocyclic compounds, and benzenoids. Using machine learning with a random forest model, we screened for potential markers of lung cancer and identified a marker panel consisting of Kanzonol Z, Xanthosine, Nervonyl carnitine, and 3,4-Dihydroxybenzaldehyde, which exhibited a diagnostic potency of 96% for the testing cohort (AUC value). Importantly, this marker panel also demonstrated effective prediction for the validation set, with an AUC value of 84%, indicating the reliability of the marker screening process. Our findings suggest that the metabolomic analysis of urinary EVs provides a promising source of non-invasive markers for lung cancer diagnostics. We believe that the EV metabolic signatures could be used to develop clinical applications for the early detection and screening of lung cancer, potentially improving patient outcomes.
资助项目	Ministry of Health Research Fund for Medical Sciences[WKJ-ZJ-1910];Wenzhou Basic Research Project[Y2020201,Y2020916];Zhejiang Provincial Natural Science Foundation[LY22H120002];
出版者	BioMed Central Ltd
ISSN	1477-3155
EISSN	1477-3155
卷号	21 期号:1
DOI	10.1186/s12951-023-01908-0
页数	10
WOS类目	Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS记录号	WOS:000988019700001
收录类别	PUBMED ; EI ; SCIE ; SCOPUS
EI入藏号	20232114148103
EI主题词	Cell proliferation
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 821 Agricultural Equipment and Methods ; Vegetation and Pest Control
URL	查看原文
PubMed ID	37189121
SCOPUSEID	2-s2.0-85159404456
通讯作者地址	[Zhu, Qingfu]National Engineering Research Center of Ophthalmology and Optometry,Eye Hospital,Wenzhou Medical University,Wenzhou,325027,China ; [Liu, Fei]The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
Scopus学科分类	Bioengineering;Medicine (miscellaneous);Molecular Medicine;Biomedical Engineering;Applied Microbiology and Biotechnology;Pharmaceutical Science
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180513
专题	眼视光学院（生物医学工程学院）、附属眼视光医院附属第一医院
通讯作者	Zhu, Qingfu; Liu, Fei
作者单位	1.Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,325000,China; 2.National Engineering Research Center of Ophthalmology and Optometry,Eye Hospital,Wenzhou Medical University,Wenzhou,325027,China; 3.Department of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei,Wuhan,430030,China; 4.Key Laboratory of Heart and Lung,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 5.Institute of Life Sciences & Engineering Laboratory of Zhejiang Province for Pharmaceutical Development of Growth Factors,Wenzhou University,Wenzhou,325035,China; 6.The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院; 附属第一医院
推荐引用方式 GB/T 7714	Yang, Qinsi,Luo, Jiaxin,Xu, Hao,et al. Metabolomic investigation of urinary extracellular vesicles for early detection and screening of lung cancer[J]. Journal of nanobiotechnology,2023,21(1).
APA	Yang, Qinsi., Luo, Jiaxin., Xu, Hao., Huang, Liu., Zhu, Xinxi., ... & Liu, Fei. (2023). Metabolomic investigation of urinary extracellular vesicles for early detection and screening of lung cancer. Journal of nanobiotechnology, 21(1).
MLA	Yang, Qinsi,et al."Metabolomic investigation of urinary extracellular vesicles for early detection and screening of lung cancer".Journal of nanobiotechnology 21.1(2023).