Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota-gut-brain axis

doi:10.1007/s00221-023-06632-7

科研成果详情

题名	Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota-gut-brain axis
作者	Zhang, Yuhe1; Chen, Yan 2; Yuan, Shushu1; Yu, Qingxia1; Fu, Jianjiong 2; Chen, Luyun 2; Liu, Jiaming1; He, Yuping2
发表日期	2023-06
发表期刊	EXPERIMENTAL BRAIN RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Gastrodin Gut microbiota IGF-1 pathway Neuronal apoptosis Cognitive impairment
其他关键词	APOPTOSIS ; DEMENTIA ; CELLS
摘要	Gastrodin (Gas) has exhibited protective activity in neurological disorders. Here, we investigated the neuroprotective effect and potential mechanisms of Gas against cognitive impairment via regulating gut microbiota. APPswe/PSEN1dE9 transgenic (APP/PS1) mice were treated intragastrically with Gas for 4 weeks, and then cognitive deficits, deposits of amyloid-beta (A beta) and phosphorylation of tau were analyzed. The expression levels of insulin-like growth factor-1 (IGF-1) pathway-related proteins, such as cAMP response element-binding protein (CREB), were detected. Meanwhile, gut microbiota composition was evaluated. Our results showed that Gas treatment significantly improved cognitive deficits and A beta deposition in APP/PS1 mice. Moreover, Gas treatment increased the level of Bcl-2 and decreased level of Bax and ultimately inhibited neuronal apoptosis. Gas treatment markedly increased the expression levels of IGF-1 and CREB in APP/PS1 mice. Moreover, Gas treatment improved abnormal composition and structure of gut microbiota in APP/PS1 mice. These findings revealed that Gas actively participated in regulating the IGF-1 pathway to inhibit neuronal apoptosis via the gut-brain axis and that it can be considered a new therapeutic strategy against Alzheimer's disease.
资助项目	Natural Science Foundation of Zhejiang Province [LGF22H090018]
出版者	SPRINGER
ISSN	0014-4819
EISSN	1432-1106
卷号	241 期号:6 页码:1661-1673
DOI	10.1007/s00221-023-06632-7
页数	13
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000990442300002
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-05
URL	查看原文
PubMed ID	37199774
SCOPUSEID	2-s2.0-85159651881
通讯作者地址	[Liu, Jiaming]Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China ; [He, Yuping]Department of Neurology,Zhuji Affiliated Hospital of Wenzhou Medical University,Zhejiang,Shaoxing,311899,China
Scopus学科分类	Neuroscience (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180179
专题	公共卫生学院_预防医学系其他_附属诸暨医院（诸暨市人民医院）
通讯作者	Liu, Jiaming; He, Yuping
作者单位	1.Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 2.Department of Neurology,Zhuji Affiliated Hospital of Wenzhou Medical University,Zhejiang,Shaoxing,311899,China
第一作者单位	预防医学系; 公共卫生学院
通讯作者单位	预防医学系; 公共卫生学院; 温州医科大学
第一作者的第一单位	预防医学系
推荐引用方式 GB/T 7714	Zhang, Yuhe,Chen, Yan,Yuan, Shushu,et al. Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota-gut-brain axis[J]. EXPERIMENTAL BRAIN RESEARCH,2023,241(6):1661-1673.
APA	Zhang, Yuhe., Chen, Yan., Yuan, Shushu., Yu, Qingxia., Fu, Jianjiong., ... & He, Yuping. (2023). Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota-gut-brain axis. EXPERIMENTAL BRAIN RESEARCH, 241(6), 1661-1673.
MLA	Zhang, Yuhe,et al."Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota-gut-brain axis".EXPERIMENTAL BRAIN RESEARCH 241.6(2023):1661-1673.