题名 | Relationships of Low Serum Levels of Interleukin-10 With Poststroke Anxiety and Cognitive Impairment in Patients With Clinical Acute Stroke |
作者 | |
发表日期 | 2023-05 |
发表期刊 | JOURNAL OF CLINICAL NEUROLOGY 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | interleukin-10 stroke mood disorder anxiety cognitive impairment |
其他关键词 | RISK-FACTORS ; IL-10 ; METAANALYSIS ; DEPRESSION ; POLYMORPHISMS ; DISORDERS ; CYTOKINES ; MICE ; LIFE |
摘要 | Background and Purpose The relationships among interleukin (IL)-10 levels, anxiety, and cognitive status after stroke remain controversial. We aimed to determine the associations of serum IL-10 levels with poststroke anxiety (PSA) and poststroke cognitive impairment (PSCI).Methods We recruited 350 patients with stroke, of whom only 151 completed a 1-month fol-low-up assessment. The Mini Mental State Examination (MMSE) and Hamilton Anxiety Scale (HAMA) were used to assess the cognitive status and anxiety, respectively. Serum IL-10 levels were measured within 24 hours of admission.Results IL-10 levels were significantly lower in the PSA group than in the non-PSA group, and they were negatively associated with HAMA scores (r=-0.371, p<0.001). After adjusting for all potential confounders, IL-10 levels remained an independent predictor of PSA (odds ratio=0.471, 95% confidence interval=0.237-0.936, p=0.032). IL-10 levels were strongly cor-related with behavior during interviews, psychic anxiety, and somatic anxiety. Patients with-out PSCI had higher IL-10 levels were higher in non-PSCI patients than in PSCI patients, and they were positively associated with MMSE scores in the bivariate correlation analysis (r=0.169, p=0.038), and also with memory capacity, naming ability, and copying capacity. However, IL-10 did not predict PSCI in the univariable or multivariable logistic regression.Conclusions Low IL-10 levels were associated with increased risks of PSA and PSCI at a 1-month follow-up after stroke. Serum IL-10 levels may therefore be helpful in predicting PSA. |
资助项目 | Healthcare Clinic of the First Affiliated Hospital of Wenzhou Medical University |
出版者 | KOREAN NEUROLOGICAL ASSOC |
ISSN | 1738-6586 |
EISSN | 2005-5013 |
卷号 | 19期号:3页码:242-250 |
DOI | 10.3988/jcn.2022.0151 |
页数 | 9 |
WOS类目 | Clinical Neurology |
WOS研究方向 | Neurosciences & Neurology |
WOS记录号 | WOS:000986733000004 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 37151141 |
SCOPUSEID | 2-s2.0-85159490955 |
通讯作者地址 | [Li, Xianmei]Department of Rehabilitation,The First Affiliated Hospital of Wenzhou Medical University,Shangcai Road, Ouhai District,Wenzhou,325000,China |
Scopus学科分类 | Neurology;Neurology (clinical) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/180168 |
专题 | 附属第一医院_急诊科 附属第二医院 第二临床医学院、附属第二医院、育英儿童医院 附属第一医院_康复科 |
通讯作者 | Li, Xianmei |
作者单位 | 1.Department of Emergency,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Rehabilitation,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Hepatological Surgery,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,China |
第一作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
通讯作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Ying, Zhao-Jian,Huang, Yuan-Yuan,Shao, Meng-Meng,et al. Relationships of Low Serum Levels of Interleukin-10 With Poststroke Anxiety and Cognitive Impairment in Patients With Clinical Acute Stroke[J]. JOURNAL OF CLINICAL NEUROLOGY,2023,19(3):242-250. |
APA | Ying, Zhao-Jian., Huang, Yuan-Yuan., Shao, Meng-Meng., Chi, Chu-Huai., Jiang, Ming-Xia., ... & Li, Xianmei. (2023). Relationships of Low Serum Levels of Interleukin-10 With Poststroke Anxiety and Cognitive Impairment in Patients With Clinical Acute Stroke. JOURNAL OF CLINICAL NEUROLOGY, 19(3), 242-250. |
MLA | Ying, Zhao-Jian,et al."Relationships of Low Serum Levels of Interleukin-10 With Poststroke Anxiety and Cognitive Impairment in Patients With Clinical Acute Stroke".JOURNAL OF CLINICAL NEUROLOGY 19.3(2023):242-250. |
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