Relationships of Low Serum Levels of Interleukin-10 With Poststroke Anxiety and Cognitive Impairment in Patients With Clinical Acute Stroke

doi:10.3988/jcn.2022.0151

科研成果详情

题名	Relationships of Low Serum Levels of Interleukin-10 With Poststroke Anxiety and Cognitive Impairment in Patients With Clinical Acute Stroke
作者	Ying, Zhao-Jian1; Huang, Yuan-Yuan2; Shao, Meng-Meng2; Chi, Chu-Huai 3; Jiang, Ming-Xia 2; Chen, Yi-Hui 2; Chen, Yu 2; Sun, Miao-Xuan2; Zhu, Yan-Yan2; Li, Xianmei2
发表日期	2023-05
发表期刊	JOURNAL OF CLINICAL NEUROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	interleukin-10 stroke mood disorder anxiety cognitive impairment
其他关键词	RISK-FACTORS ; IL-10 ; METAANALYSIS ; DEPRESSION ; POLYMORPHISMS ; DISORDERS ; CYTOKINES ; MICE ; LIFE
摘要	Background and Purpose The relationships among interleukin (IL)-10 levels, anxiety, and cognitive status after stroke remain controversial. We aimed to determine the associations of serum IL-10 levels with poststroke anxiety (PSA) and poststroke cognitive impairment (PSCI).Methods We recruited 350 patients with stroke, of whom only 151 completed a 1-month fol-low-up assessment. The Mini Mental State Examination (MMSE) and Hamilton Anxiety Scale (HAMA) were used to assess the cognitive status and anxiety, respectively. Serum IL-10 levels were measured within 24 hours of admission.Results IL-10 levels were significantly lower in the PSA group than in the non-PSA group, and they were negatively associated with HAMA scores (r=-0.371, p<0.001). After adjusting for all potential confounders, IL-10 levels remained an independent predictor of PSA (odds ratio=0.471, 95% confidence interval=0.237-0.936, p=0.032). IL-10 levels were strongly cor-related with behavior during interviews, psychic anxiety, and somatic anxiety. Patients with-out PSCI had higher IL-10 levels were higher in non-PSCI patients than in PSCI patients, and they were positively associated with MMSE scores in the bivariate correlation analysis (r=0.169, p=0.038), and also with memory capacity, naming ability, and copying capacity. However, IL-10 did not predict PSCI in the univariable or multivariable logistic regression.Conclusions Low IL-10 levels were associated with increased risks of PSA and PSCI at a 1-month follow-up after stroke. Serum IL-10 levels may therefore be helpful in predicting PSA.
资助项目	Healthcare Clinic of the First Affiliated Hospital of Wenzhou Medical University
出版者	KOREAN NEUROLOGICAL ASSOC
ISSN	1738-6586
EISSN	2005-5013
卷号	19 期号:3 页码:242-250
DOI	10.3988/jcn.2022.0151
页数	9
WOS类目	Clinical Neurology
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000986733000004
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37151141
SCOPUSEID	2-s2.0-85159490955
通讯作者地址	[Li, Xianmei]Department of Rehabilitation,The First Affiliated Hospital of Wenzhou Medical University,Shangcai Road, Ouhai District,Wenzhou,325000,China
Scopus学科分类	Neurology;Neurology (clinical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180168
专题	附属第一医院_急诊科附属第二医院第二临床医学院、附属第二医院、育英儿童医院附属第一医院_康复科
通讯作者	Li, Xianmei
作者单位	1.Department of Emergency,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Rehabilitation,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Hepatological Surgery,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Ying, Zhao-Jian,Huang, Yuan-Yuan,Shao, Meng-Meng,et al. Relationships of Low Serum Levels of Interleukin-10 With Poststroke Anxiety and Cognitive Impairment in Patients With Clinical Acute Stroke[J]. JOURNAL OF CLINICAL NEUROLOGY,2023,19(3):242-250.
APA	Ying, Zhao-Jian., Huang, Yuan-Yuan., Shao, Meng-Meng., Chi, Chu-Huai., Jiang, Ming-Xia., ... & Li, Xianmei. (2023). Relationships of Low Serum Levels of Interleukin-10 With Poststroke Anxiety and Cognitive Impairment in Patients With Clinical Acute Stroke. JOURNAL OF CLINICAL NEUROLOGY, 19(3), 242-250.
MLA	Ying, Zhao-Jian,et al."Relationships of Low Serum Levels of Interleukin-10 With Poststroke Anxiety and Cognitive Impairment in Patients With Clinical Acute Stroke".JOURNAL OF CLINICAL NEUROLOGY 19.3(2023):242-250.